Cell

The response to drug combinations critically depends on how their biological targets are connected, according to a study published online in Molecular Systems Biology this week. Understanding how multi-drug combinations work is vital in medicine, in order to rationalize their use and discover novel targets.

Making a splash, or not, Ballistic breakthrough, NanoBuds are here, Genetic variant associated with triglyceride levels, Genetic variant protects against four infectious diseases, Potential therapeutic target in Down syndrome

Scientists have for the first time successfully replaced natural teeth in mice with teeth that were created in a Petri dish from single cells. The experiment is described online this week in Nature Methods.

In utero protein regulation, Common genetic variant protects against breast cancer, Large-scale survey of mutations in cancer, Sleep deprivation impairs subsequent learning, Human adult stem cells can regenerate muscle, Viral highways: spreading from cell to cell, Finding phosphates on proteins

Quantum optics: A trick of the light, Neuroscience: New target for Parkinson's disease, Climate change: Reviewing strategies, Immunology: Receptor for New World haemorrhagic fever viruses found, Palaeoclimate: Global continental cooling, Genetics: ‘Out of Africa’ with Helicobacter pylori, Seal of approval

The development of a population of ‘regulatory’ immune cells is more complicated than originally thought, according to a paper to be published online this week in Nature Immunology.

Summaries of newsworthy papers include Not losing sleep over the orexins, Potential new therapeutic target in breast cancer, The molecules behind Angelman syndrome, Sun worshipers, A mouse shows us how the brain works

University research activities have always been an important factor in societal progress. Thus, it is important for universities to communicate their research to the public. Keio’s Annual Report on Research Activities provides the community with information regarding our strategies and direction, as well as our current research activities.

Summaries of newsworthy papers from Nature include Cancer cleared by p53 restoration, Algorithm seeks out smell, Essays: Putting the pieces together, Quantum physics: To bunch or not to bunch and Fight-watching fish fathom hierarchies

A breakthrough technology developed at IBN can potentially lead to more effective treatment methods for cancers

The December issue of Keio Journal of Medicine is now available online.

Summaries of newsworthy papers for Nature and the Nature Research Journals that will be published online on 17 December 2006. Genetic mutation in autism, Synchronized sleeping in the brain and Humans follow the scent

A set of guidelines for pathologists that may greatly improve the diagnosis of malignant lymphomas are published online this week by Leukemia. In five related papers, a group of leading scientists participating in the EU-supported BIOMED-2 programme report a new test that could be used as an efficient and cost-effective method to diagnose lymphomas

Summaries of newsworthy papers from Nature Research Journals include Mycobacterium tuberculosis copper regulator found – Nature Chemical Biology, Key to relapsing multiple sclerosis – Nature Immunology, Fast 3D imaging of brain cell networks – Nature Methods

The constant presence of a population of ‘regulatory’ immune cells is essential for the prevention of autoimmune disease, according to a paper published in the February issue of Nature Immunology.

Summaries of newsworthy papers from Nature. VOL.444 NO. 7119 include Cancer: Cell senescence cancer link, Climate change: Gulf Stream weakened during Little Ice Age, Physiology: A toast to good health…. Material science: Terahertz-controlling device, The alchemy of violin-making

Summaries of newsworthy papers include Protein monitors arrested eggs for DNA damage, Mount St Helens rock causes ‘drumbeats’, Drug promise for renal disease, By their teeth ye shall know them, Corals take a battering, Watching proteins unfold, Superconducting silicon, Hessian ware recipe

Summaries of newsworthy papers include Nanomaterials for imaging and therapy – Nature Materials, High times for memory – Nature Neuroscience, An unexpected mechanism of pain – Nature Neuroscience, Auditory repetition and dyslexia – Nature Neuroscience

Researchers have discovered two mutations in the H5N1 avian influenza virus that enable it to recognise human receptor proteins. The amino acid changes, might prove useful molecular markers for assessing the pandemic potential of H5N1 samples.

Climate change: New Antarctic ice core yields detailed climatic insights, Infectious disease: SIV endemic in wild gorillas?, Neuroscience: How to keep a steady eye, Astronomy: Moon’s surface shaped by ‘recent’ gas release? and finally… Chillies and spiders share similar scare tactics

Summaries of newsworthy papers from Nature and Nature Research Journals include: DNA sequencing reveals bacterial evolution in the lab, Kidney disease caused by mutation may be reversible, Benefits of fever, Redefining receptor organization – again.

Having your cake and eating it too, ‘Silver bullet’ strategies due a rethink, Rock-solid support for ‘Snowball Earth’ theory, The benefits of sleeping around, Tiny mirrors chill out, New sonic hedgehog receptor, Maize fungal genome deciphered, ‘Export’ protein structure unveiled, Policing every egg you lay

Magnetic cooling demonstrated in a gas, A step towards quantum networks, Seeing the benefits of nanoceria, A potential male contraceptive, Towards a complete human ‘epigenome’, Small RNAs drive evolution, Genetic risk for schizophrenia and brain function, Knocking out false positives in interaction proteomics

A new technology that mimics the suspension of white blood cells in blood in the body is reported online this week in Cell Research. The novel joystick-controlled laser traps that the authors use provide valuable new information on how white blood cells engulf bacteria – a crucial part of the body’s defense against infection.

Summaries of other newsworthy papers from Nature include Inducing connections between brain sites alters motor function - Nature, The bottom line for silk - Nature Materials, Bittersweet news for neural stem cell grafts - Nature Medicine, TAPping into mammalian interaction proteomics - Nature Methods

The culture conditions under which human embryonic stem cells can be converted into cells that produce all five hormones made by the pancreas, including insulin, are reported online in Nature Biotechnology this week.

‘Linguistics’ spawns new antimicrobial drugs, Stop picking on the big guys, Moon's south pole unlikely to have thick ice deposits, Bang on in the Andromeda galaxy, Cancer stem cells resist radiotherapy, Primitive fish surprisingly advanced, Neurodegeneration, Two pores colliding, Getting to the roots of the fungal family tree.......

Summaries of newsworthy papers from Nature Journals include New sex determination gene identified - Nature Genetics, Towards better anti-epileptic drugs - Nature Neuroscience, We have no blue bananas - Nature Neuroscience

Vaccinating the Ethiopian wolf, Titan's ocean lost forever?, Oxygen puzzle solved?, Modelling the early Universe, Controlling the insulin-degrading enzyme may relieve Alzheimer’s disease, Towards a quantum network and finally… Salamanders see red

A molecule that makes mammals feel full up has been identified, and drugs that target it may help to treat obesity. Other newsworthy papers include Vision: Bug eyes get a makeover - Nature, One step toward more efficient cloning - Nature Genetics, New strategy for controlling inflammation - Nature Immunology