Nano Letters


11 Mar 2024
Researchers from Osaka University used tip-scan high-speed atomic force microscopy combined with an optical microscope to observe light-induced deformation of azo-polymer films. The process could be followed in real time, and the film patterns were found to change with the polarization of the light source. The observations will contribute to the use of azo-polymers in applications such as optical data storage, and the approach is expected to be useful across materials science and physical chemistry.
11 Jan 2024
Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University report in Nano Letters how the flexibility of a protein hinge plays a crucial role in the transfer of proteins in key cell processes.
06 Nov 2023
Researchers at the Institute of Industrial Science, The University of Tokyo study the quantum mechanical phenomenon known as vacuum fluctuations using a nanoscale hybrid device, which may lead to ultrasensitive quantum sensors or information processors.
26 May 2023
Graphene has revolutionized materials science since its discovery in 2004, with its high electron mobility, mechanical strength, and thermal conductivity. But processing graphene at the micro/nanoscale is a challenging process that often involves large-scale equipment and complex operations. Now, Tohoku University researchers have applied their simple femtosecond laser technique to ultra-thin atomic layers of graphene, resulting in multi-point hole drilling without damaging the graphene film.
15 May 2023
Researchers at Kanazawa University report in Nano Letters how high-speed atomic force microscopy leads to insights into processes relevant to Alzheimer’s disease. Moreover, the technique is shown to be an excellent tool for studying the effect of drugs against the disease.
Revolutionary nanovalve enables active control of single-molecule flows
01 May 2023
A joint research group at Osaka Metropolitan University has succeeded in regulating the flow of single molecules in solution by opening and closing the nanovalve mounted on the nanofluidic device by applying external pressure. The research group fabricated a device with a ribbon-like, thin, soft glass sheet on the top, and at the bottom a hard glass substrate having nanochannels and nanovalve seats. By applying external pressure to the soft glass sheet to open and close the valve, they succeeded in directly manipulating and controlling the flow of individual molecules in solution. They also observed an effect of fluorescence signal amplification when single fluorescent molecules are confined in the tiny nanospace inside the valve. The effect can be ascribed to the nanoconfinement, which suppresses the random motion of the molecules.
02 Mar 2023
Osaka Metropolitan University researchers have used 100 seconds of laser irradiation to generate convection currents that selectively accelerate biochemical reactions—due to the photothermal effect—by concentrating biofunctional molecules at the cell surface. Using this method, useful molecules can be transported into cells at concentrations a hundred to a thousand times lower than with conventional methods. Furthermore, they also succeeded in selectively introducing small molecules into intracellular organelles usually impossible at low concentrations (hundreds of pmol/L) as well as inducing cell death in targeted cells by concentrating anticancer active peptides into them at concentrations so low that they would not be conventionally effective (several tens of nmol/L).
28 Feb 2023
Researchers at Kanazawa University report in Nano Letters the discovery of a biomolecular dynamical process likely relevant to gene expression. The process, revealed by means of high-speed atomic force microscopy, involves DNA and its packaging molecules.
Visualization of coronavirus causing Covid19
19 Jan 2023
Researchers at Kanazawa University report in Nano Letters how high-speed atomic force microscopy can be used to assess the effectivity of spike-neutralizing antibodies for preventing COVID-19. The use of such antibodies offers a promising alternative to vaccines.
28 Jul 2022
Researchers from Osaka University and collaborating partners measured intracellular temperature gradients in human-derived cells at unprecedented spatial, temporal, and readout resolution. Intracellular temperature is a fundamental indicator of health, and corresponding gradients are the subject of medical hypotheses as well as potential drug development directions. The results of this work will advance such research by providing a versatile tool that's compatible with standard technology and procedures.
27 Jul 2022
Researchers from Osaka University and collaborating partners used straightforward chemical synthesis to modulate the phase transition of a thermal conductivity-switching block copolymer. Reversible changes in the nanostructured anisotropy in the material corresponded to an approximately two-fold change in the thermal conductivity, over the 27°C to 147°C temperature range. These results will enhance the sustainability of upcoming advanced flexible organic electronics.
creating a single molecule transistor (SMT) by mounting a single water molecule in a C60 cage between two gold electrodes.
06 Jan 2022
A collaborative team led by researchers from Institute of Industrial Science, The University of Tokyo uses a single water molecule in a C60 cage to probe quantum mechanics
02 Dec 2021
Researchers from the The University of Tokyo Institute of Industrial Science use electron energy loss spectroscopy to understand local thermal behavior at grain boundaries in polycrystals
Nanofluidic device
19 Oct 2021
When liquid meets gas, a unique zone forms. Variable by nature, molecules can cross from one state to another, combining in unique ways to either desirable or unwanted ends. From heat escaping a mug of coffee to increasing molecular concentrations in chemical solutions, gas-liquid interfaces are ubiquitous across nature and engineering. But a lack of tools capable of precisely controlling such gas-liquid interfaces limit their applications — until now.
20 Nov 2020
A research team, affiliated with South Korea's Ulsan National Institute of Science and Technology (UNIST) has succeeded in analyzing the structure of the sulfide-based solid electrolytes (SEs) at the atomic level.
16 Aug 2020
Researchers in Kanazawa University has recently reported their study in Nano Letters regarding a high-speed atomic force microscopy study on a biological event that happens during flu virus enters infects its host cell. The real-time visualization of influenza A hemagglutinin (HA) has enhanced the understanding of fusogenic transition of HA and its interactions with host endosomes.
09 Jul 2020
Scientists in Korea explain a new process that maximizes photon conversion in 2D materials, which could innovate photonic-based applications
30 Apr 2020
A multinational team of researchers from Tohoku University and institutions in the UK, Germany and Switzerland has revealed the magnetic states of nanoscale gyroids, 3D chiral network-like nanostructures. The findings add a new candidate system for research into unconventional information processing and emergent phenomena relevant to spintronics.
10 Mar 2020
A recent study, affiliated with South Korea's Ulsan National Institute of Science and Technology (UNIST) has introduced a novel technology, which allows carbon nanotubes (CNTs) to be easily observed under room temperature.
06 Feb 2020
A nanoscale gold butterfly provides a more precise route for growing/synthesizing nanosized semiconductors that can be used in nano-lasers and other applications.
Obtained unusual nanostructures
18 Oct 2019
A research team of Ehime University paved a way to achieve unexplored III-V semiconductor nanostructures. They grew branched GaAs nanowires with a nontoxic Bi element employing characteristic structural modifications correlated with metallic droplets, as well as crystalline defects and orientations. The finding provides a rational design concept for the creation of semiconductor nanostructures with the concentration of constituents beyond the fundamental limit, making it potentially applicable to novel efficient near-infrared devices and quantum electronics.
26 Aug 2019
A joint research team, affiliated South Korea's Ulsan National Institute of Science and Technology (UNIST) has developed a high-performance metal electrode (carbon fiber-metal composite) through a process of penetrating liquid metal into fine gaps of carbon fiber.
26 Aug 2019
A recent study, affiliated with South Korea's Ulsan National Institute of Science and Technology (UNIST) has presented a new perovskite light-emitting diodes (PeLEDs) with high flexibility.
Senior Researcher Changsoon Choi from DGIST Department of Smart Textile Convergence Research (left) and Dr. Sungwoo Chun from Sungkyunkwan University (right)
06 Aug 2019
Senior Researcher Changsoon Choi's team at DGIST and Dr. Sungwoo Chun at SKKU developed a new tactile sensor mimicking human skin. Can recognize more sensitive tactile than the existing sensors... Expected to contribute greatly to the development of artificial skin.
Image Name
31 May 2019
Researchers have successfully used DNA origami to make smooth-muscle-like contractions in large networks of molecular motor systems, a discovery which could be applied in molecular robotics.


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