Dr. Andrea Kwa Lay Hoon

Dr Kwa is currently a Pharmacy Clinician Scientist and Assistant Director, Pharmacy (Research), at the Singapore General Hospital. She specializes in critical care medicine, infectious diseases and antimicrobial resistance research.


PharmD (Pharmacy), Albany College of Pharmacy and Health Sciences, New York, US
BSc(Pharm) Pharmacy, National University of Singapore (1996)

Research Interest

• Elucidation of multiple antibiotics in combination against extreme drug resistant bacteria in an one compartment static in-vitro model or a dyamic in-vitro pharmacokinetic/pharmacodynamic two-compartmental model simulating fluctuating clinically achievable antibiotic concentrations.
• Population pharmacokinetics/pharmacodynamics of antimicrobials.
• Molecular diagnostics in fungal diseases and anti-fungal resistance.
• Risk factors and outcomes via statistical modelling.
• Health services research involving antimicrobial stewardships.

Selected news links:

Selected publications

Liew, Y. X., Lee, W., Loh, J.C., Cai, Y., Tang, S.S., Lim, C.L., Teo, J., Ong, R.W., Kwa, A.L. and Chlebicki, M.P. (2012) Impact of an antimicrobial stewardship programme on patient safety in Singapore General Hospital. Int J Antimicrob Agents. Jul;40(1):55-60. Epub 2012 May 14.

Teo, J., Cai, Y., Tang, S., Lee, W., Tan, T.Y., Tan, T.T. and Kwa, A.L. (2012) Risk factors, molecular epidemiology and outcomes of ertapenem-resistant, carbapenem-susceptibleEnterobacteriaceae: a case-case-control study. PLoS One. 7(3):e34254. Epub 2012 Mar 26.

Lim, T.P., Lee, W., Tan, T.Y., Sasikala, S., Teo, J., Hsu, L.Y., Tan, T.T., Syahidah, N. and Kwa, A.L. (2011) Effective antibiotics in combination against extreme drug-resistant Pseudomonas aeruginosa with decreased susceptibility to polymyxin B. PLoS One. 6(12):e28177. Epub 2011 Dec 5.

Kwa, A.L., Abdelraouf, K., Low, J.G. and Tam, V.H. (2011) Pharmacokinetics of polymyxin B in a patient with renal insufficiency: a case report. Clin Infect Dis. May;52(10):1280-1.

Lim, T.P., Tan, T.Y., Lee, W., Sasikala, S., Tan, T.T., Hsu, L.Y. and Kwa, A.L. (2011) In-vitro activity of polymyxin B, rifampicin, tigecycline alone and in combination against carbapenem-resistant Acinetobacter baumannii in Singapore. PLoS One. Apr 21;6(4):e18485.

Roberts, J.A., Kwa, A., Montakantikul, P., Gomersall, C., Kuti, J.L. and Nicolau, D.P. (2011) Pharmacodynamic profiling of intravenous antibiotics against prevalent Gram-negative organisms across the globe: the PASSPORT Program-Asia-Pacific Region. Int J Antimicrob Agents. Mar;37(3):225-9.

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Associate Professor
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