Medicine & Healthcare Pharmaceutical sciences
24 Jan 2022
Broccoli may contain advantages beyond nutrition. A molecule found in broccoli, cabbage and more digests down into DIM, a compound with brighter benefits than the name implies, such as inducing cell death in breast, prostate and colon cancer. Now, researchers are beginning to understand the mechanism underpinning this molecular behavior — information that could help elucidate future anti-cancer treatments.
27 Dec 2021
Researchers from Osaka City University have shown in mice models of Alzheimer's disease, frontotemporal dementia, and dementia with Lewy bodies, that the intranasal administration of rifampicin and resveratrol in combination is safer and improves cognitive function more than rifampicin alone. The research results are expected to lead to the development of safe and effective nasal spray for the prevention of dementia.
17 Sep 2021
A specially designed lipid nanoparticle could deliver immune-signaling molecules into liver macrophage cells to overcome resistance to anti-tumor immunotherapy.
10 Sep 2021
Researchers have identified a potential reason why lower numbers of COVID cases have appeared amongst smokers compared to non-smokers, even as other reports suggest smoking increases severity of the disease.
02 Sep 2021
Researchers at Kanazawa University describe in Scientific Reports the identification of small compounds that can regulate the cellular production of extracellular vesicles — nanocontainers transporting biomolecules between cells. Such compounds hold promise for use in therapies for various diseases.
30 Jul 2021
Testing a large library of compounds reveals an easy-to-make lipid that can carry genetic code into the lung to treat disease.
23 Dec 2020
A stress response of mitochondria, the part of our cells that produce energy to power bodily functions, is important to a longer life. A team of scientists from Osaka City University, Japan, searched through a chemical “library” of existing drugs to find one that can activate this stress response in the worm Caenorhabditis elegans. They found that an anti-hypertension drug called metolazone prolongs C. elegans lifespan, marking the first step in developing anti-aging pharmaceuticals.
28 Sep 2020
Researchers from the University of Tsukuba demonstrate that the hypnotic and teratogenic effects of thalidomide are separable. Thalidomide is a medication with several different effects, one of which is promoting sleep in the context of insomnia. In a new study, researchers from the University of Tsukuba have discovered that thalidomide exerts its hypnotic effects through mechanisms distinct from those for the drug’s notorious teratogenicity. These are striking results showing how thalidomide induces sleep independently of its known effects on the teratogenic cereblon pathway. These findings could be helpful in developing novel thalidomide-like hypnotic drugs without thalidomide’s teratogenic effects. The study was published in the scientific journal Proceedings of the National Academy of Sciences of the United States of America.
18 Sep 2020
Drugs tackling chronic myelogenous leukemia have completely transformed prognoses of patients over the last couple of decades, with most cases going into remission. But drug resistance can occur, leading to relapses. Targeting the lipids involved in regulating part of a leukemia stem cell’s life span offers a potential second route to defeat the disease—and solid tumorous cancers as well.
20 Aug 2020
A new catalyst design enables unprecedented control over the modification of fatty acid derivatives that opens the door to creating useful substances in a green and efficient manner.
19 May 2020
Scientists from Hong Kong Baptist University (HKBU) have developed a novel technique that can produce pure therapeutic drugs without the associated side effects.
12 Jan 2020
The drugs helped mice and humans recall long-term object memories.
26 Aug 2019
A recent study, affiliated with South Korea's Ulsan National Institute of Science and Technology (UNIST) has introduced an artificial catalytic reactor that can take control of chemical reactions inside living cells, as desired.
26 Apr 2019
BDP Week 2019 in China enjoys unparralleled industry support and is known for generating knowledge, creating business opportunities, and bringing innovative ideas to the table.
09 Dec 2020 to 11 Dec 2020
Singapore's long-running Pharmaceutical Manufacturing Industry learning and networking event, featuring a stellar profile of C-suite experts and firms.
03 Nov 2020 to 05 Nov 2020
Your go-to event to reach out to key decision makers in the pharmaceutical industry. The event will be delivered digitally from 3-5 November 2020.
Dr Kwa is currently a Pharmacy Clinician Scientist and Assistant Director, Pharmacy (Research), at the Singapore General Hospital. She specializes in critical care medicine, infectious diseases and antimicrobial resistance research.
My research background covers multidisciplinary fields such as Pharmaceutics, Cancer Nanomedicine, Bioengineering and Organ-on-a-chip platforms. My current research focuses on the development of dynamic biological barriers on a chip such as blinking human cornea on a chip.