Prof. David B. Matchar

Prof Matchar's research relates to clinical practice improvement - from the development of clinical policies to their implementation in real world clinical settings

Prof Matchar has worked in clinical research for over 35 years and his work primarily relates to stroke and other chronically disabling neurological disorders, as well as clinical and public policy analysis. He served as Director of the Duke Centre for Clinical Health Policy Research and established the Duke Evidence-based Practice Center, which was responsible for analysis in support of coverage policy for the US Centers for Medicare and Medicaid Services, as well as guidelines for medical professional societies.


M.D., University of Maryland, College Park, 1980
AB in Statistics, Princeton University

Notable features of his work:

(1) reliance on analytic strategies such as meta-analysis, simulation, decision analysis and cost-effectiveness analysis;
(2) a balancing of methodological rigor the needs of medical professionals; and
(3) dependence on interdisciplinary groups of experts.


STaR Investigator Award by the Singapore Ministry of Health’s (MOH) National Medical Research Council (NMRC) and the Agency for Science, Technology and Research (A*STaR)

Selected publications

Tan, Chorh Chuan, Carolyn S. P. Lam, David B. Matchar, Yoong Kang Zee, and John E. L. Wong. “Singapore's health-care system: key features, challenges, and shifts.” Lancet 398, no. 10305 (September 18, 2021): 1091–1104.

Matchar, David Bruce, Sherry Hsueh Yi Young, Rita Sim, Christine Jia Ying Yu, Xiaoxi Yan, Deidre Anne De Silva, and Bibhas Chakraborty. “Incentives for Uptake of and Adherence to Outpatient Stroke Rehabilitation Services: A Three-Arm Randomized Controlled Trial.” Arch Phys Med Rehabil, September 10, 2021.

Seow-En, Isaac, Aik Yong Chok, David Bruce Matchar, Sungwon Yoon, Dawn Qingqing Chong, and Emile Kwong-Wei Tan. “Long-term quality of life, sexual health and gastrointestinal function following colorectal cancer resection in an Asian cohort.” Colorectal Dis 23, no. 9 (September 2021): 2348–60.

Ng, Ted Kheng Siang, David Bruce Matchar, Timothy V. Pyrkov, Peter O. Fedichev, Angelique Wei-Ming Chan, and Brian Kennedy. “Association between housing type and accelerated biological aging in different sexes: moderating effects of health behaviors.” Aging (Albany Ny) 13, no. 16 (August 29, 2021): 20029–49.

Xie, Feng, Marcus Eng Hock Ong, Johannes Nathaniel Min Hui Liew, Kenneth Boon Kiat Tan, Andrew Fu Wah Ho, Gayathri Devi Nadarajan, Lian Leng Low, et al. “Development and Assessment of an Interpretable Machine Learning Triage Tool for Estimating Mortality After Emergency Admissions.” Jama Netw Open 4, no. 8 (August 2, 2021): e2118467.


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