Professor MINYAN WANG
Prof. Wang is a full professor of Neuroscience in the Department of Biological Sciences at Xi’an Jiaotong-Liverpool University and holds an honorary position at the University of Liverpool in the United Kingdom. She received her bachelor in Pharmacy & MRes in Pharmacology from Hebei Medical University, her Migraine Trust-funded Ph.D in Neuropharmacology from University of Bradford, held postdoctoral fellowships at the Institute of Neurobiology at the University of Newcastle/University of Bradford in the United Kingdom. She became academic staff at the School of Pharmacy and Biomedical Sciences at the University of Central Lancashire, and later joined XJTLU in 2011 and led the Centre for Neuroscience.
My research has focused on migraine pathogenesis. Leading many projects with international collaborations, my work has advanced the understanding of the signaling pathways involved in the pathogenesis of migraines, serving as a foundation for drug target identification and drug development. These include researching membrane receptors, calcitonin gene-related peptide (CGRP), stress-sensing cation channels and intracellular kinases involved in central and trigeminovascular system sensitization. The findings addressed how these signals sensitize the central nervous system and trigeminal nerve to trigger migraine. Additionally, my work has extended to include epigenetic profile in migraine conditions, aiming to design peptide-designed molecules to gain more insights into this 2nd disabling disease mechanism and therapy.
Selected publications
- Huang, Z; Li, X; Wang, X; Wu, J; Gong, Z; Koks, S; Wang, M*. Nuclear paraspeckle assembly transcript 1 (NEAT1) promotes photophobia behavior in mice via miR-196a-5p/Trpm3 coupling. 2025(26):118. https://doi.org/10.1186/s10194-025-02057-5 J Head Pain (J1, Featured Article)
- Huang Z, Yao J, Nie L, Nie XC, Xiong XCH, Kõks S, Quinn JP, Aditi Kanhere, Wang M*. Gender-different effect of Src family kinases antagonism on photophobia and trigeminal ganglion activity. J Head Pain, 2024, 2024(25):175. (J1)
- Nie L, Sun K, Gong Z, Li H, Quinn JP, Wang, M*. Src Family Kinases Facilitate the Crosstalk between CGRP and Cytokines in Sensitizing Trigeminal Ganglion via Transmitting CGRP Receptor/PKA Pathway. Cells 2022, 11, 3498. https://doi.org/10.3390/cells11213498 (J1)
- Jiang LW, Ma DQ, Grubb BD, Wang M*. ROS/TRPA1/CGRP signaling mediates cortical spreading depression. Journal of Headache Pain. 2019 Mar 6;20(1):25. (J1)
- Wang Y, Tye AE, Zhao JL, Ma DQ, Raddant AC, Bu F, Spector BL, Winslow NK, Wang M*, Russo AF*. Induction of calcitonin gene-related peptide expression in rats by cortical spreading depression. Cephalalgia 2016. DOI: 10.1177/0333102416678388. (J1)
- Wang M*, Gong Z, Huang Z. Src family kinases (SFKs) in migraine. Chapter 9 In part II: Druggable targets. Book title: Migraine Pain Management: Current Pharmacological and Non-pharmacological Options. Editor;1st Edition - November 1, 2024. Editor: Stephen B. Shrewsbury. ISBN: 9780443247057/ 9 7 8 - 0 - 4 4 3 - 2 4 7 0 5 – 7. eBook ISBN: 9780443247040. https://shop.elsevier.com/books/migraine-pain-management/shrewsbury/978-...

