This press release contains:
· Summaries of newsworthy papers:
Genetics: Soft-tissue sarcoma genomes
Geoscience: Moon’s mantle exposed in craters
· Mention of papers to be published at the same time with the same embargo
· Geographical listing of authors
PDFs of all the papers mentioned on this release can be found in the relevant journal’s section of http://press.nature.com. Press contacts for the Nature journals are listed at the end of this release.
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NOTE: Once a paper is published, the digital object identifier (DOI) number can be used to retrieve the abstract and full text from the journal web site (abstracts are available to everyone, full text is available only to subscribers). To do this, add the DOI to the following URL: http://dx.doi.org/ (For example, http://dx.doi.org/10.1038/ng730). For more information about DOIs and Advance Online Publication, see http://www.nature.com/ng/aop/.
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[1] Genetics: Soft-tissue sarcoma genomes
DOI: 10.1038/ng.619
The genomic analyses of a diverse sample of soft-tissue sarcomas—cancer that develops in connective tissue—is reported this week in Nature Genetics. The study identifies genes and signaling pathways involved in various sarcoma subtypes, suggesting potential subtype-specific therapeutic targets.
Soft-tissue sarcomas account for less than one percent of all cancers and are more frequently found in individuals over 50 years of age. Samuel Singer and colleagues report an integrative genomic analysis of 207 soft-tissue sarcoma tumors. As soft-tissue sarcomas are histologically heterogeneous, the samples included representative samples from each of seven major subtypes. The study provides a comprehensive resource for characterizing these diverse sarcoma subtypes for DNA sequence, DNA copy number, and mRNA expression changes. The scientists find several genes that are frequently mutated in particular subtypes, and highlight subtype-specific genomic alterations.
Author contact:
Samuel Singer (Memorial Sloan-Kettering Cancer Center, New York City, NY, USA)
Tel: +1 212 639 2940
E-mail: [email protected]
[2] Geoscience: Moon’s mantle exposed in craters
DOI: 10.1038/ngeo897
Abundant rocks from deep below the Moon’s surface are exposed in concentric rings around craters according to a paper online this week in Nature Geoscience. These rocks are rich in the mineral olivine, which is thought to originate from within the mantle, underneath the crust. This work gives us an insight into development of the Moon’s mantle.
Satoru Yamamoto and colleagues used equipment on board the lunar explorer SELENE/Kaguya to survey the composition of the Moon’s surface. Exposures of olivine were limited to concentric regions around impact craters that have thin crust. The researchers suggest that large impacts penetrated the outer crust, exposing the mantle olivine stored deeper below the surface. If true, this finding supports the theory that at some point in the Moon’s history its mantle overturned, bringing olivine-rich rocks closer to the surface.
In an accompanying News and Views article, Paul Lucey writes that this work provides “a glimpse at the evolution of the lunar mantle”.
Author contact:
Satoru Yamamoto (National Institute for Environmental Studies, Tsukuba, Japan )
Tel: +81 29 850 2589
E-mail: [email protected]
Paul Lucey (University of Hawaii at Manoa, Honolulu, HI, USA) News & Views author
Tel: +1 808 956 3137
E-mail: [email protected]
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Items from other Nature journals to be published online at the same time and with the same embargo:
Nature
[3] Sparse coding and high-order correlations in fine-scale cortical networks
DOI: 10.1038/nature09178
NATURE CHEMICAL BIOLOGY
[4] Palmitoylome profiling reveals S-palmitoylation-dependent anti-viral activity of IFITM3
DOI: 10.1038/nchembio.405
NATURE CHEMISTRY
[5] Experimental probing of conical intersection dynamics in the photodissociation of thioanisole
DOI: 10.1038/nchem.702
[6] Computational evidence that hyperconjugative interactions are not responsible for the anomeric effect
DOI: 10.1038/nchem.721
[7] Electrically induced bonding of DNA to gold
DOI: 10.1038/nchem.722
[8] Two- and three-dimensional extended solids and metallization of compressed XeF2
DOI: 10.1038/nchem.724
NATURE GENETICS
[9] A genome-wide association study identifies genetic variants in the CDKN2BAS locus associated with endometriosis in Japanese
DOI: 10.1038/ng.612
[10] TOP2B induced by androgens mediates double-strand breaks and prostate cancer gene rearrangements
DOI: 10.1038/ng.613
[11] Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes
DOI: 10.1038/ng.620
[12] Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
DOI: 10.1038/ng.621
NATURE IMMUNOLOGY
[13] T cells expressing the transcription factor PLZF regulate the development of memory-like CD8+ T cells
DOI: 10.1038/ni.1898
NATURE MATERIALS
[14] Multistability of a coherent spin ensemble in a semiconductor microcavity
DOI: 10.1038/nmat2787
Nature MEDICINE
[15] Modulation of histone H3 lysine 56 acetylation as an antifungal therapeutic strategy
DOI: 10.1038/nm.2175
NATURE METHODS
[16] A photoactivatable marker protein for pulse-chase imaging with superresolution
DOI: 10.1038/nmeth.1477
[17] Fast high-contrast imaging of animal development with scanned light sheet-based structured illumination microscopy
DOI: 10.1038/nmeth.1476
NATURE NANOTECHNOLOGY
[18] Light-driven nanoscale plasmonic motors
DOI: 10.1038/nnano.2010.128
[19] Hysteresis-free operation of suspended carbon nanotube transistors
DOI: 10.1038/nnano.2010.129
[20] Long spin-relaxation time in a single metal nanoparticle
DOI: 10.1038/nnano.2010.130
Nature NEUROSCIENCE
[21] Neural substrates for expectation-modulated fear learning in the amygdala and periaqueductal gray
DOI: 10.1038/nn.2594
[22] The nuclear import of Frizzled2 by Importins-beta11 and alpha2 promotes postsynaptic development
DOI: 10.1038/nn.2593
[23] Competitive regulation of synaptic Ca influx by D2 dopamine and A2A adenosine receptors in striatopallidal neurons
DOI: 10.1038/nn.2592
Nature PHYSICS
[24] Observation of pseudogap behavior in a strongly interacting Fermi gas
DOI: 10.1038/nphys1709
[25] Solid-liquid phase transitions in confined water films
DOI: 10.1038/nphys1708
[26] Zero-doping state and electron-hole asymmetry in an ambipolar cuprate
DOI: 10.1038/nphys1717
Nature STRUCTURAL & MOLECULAR BIOLOGY
[27] Dynamic structure of membrane-anchored Arf•GTP
DOI: 10.1038/nsmb.1853
[28] Crystal structure of the conserved herpesvirus fusion regulator complex gH–gL
DOI: 10.1038/nsmb.1837
[29] iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution
DOI: 10.1038/nsmb.1838
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GEOGRAPHICAL LISTING OF AUTHORS
The following list of places refers to the whereabouts of authors on the papers numbered in this release. The listing may be for an author's main affiliation, or for a place where they are working temporarily. Please see the PDF of the paper for full details.
BELGIUM
Leuven: 11
CANADA:
Montreal: 15
GERMANY
Braunschweig: 12
Frankfurt: 17
Heidelberg: 17, 29
Jena: 12
Karlsruhe: 16, 17
Mannheim: 12
Munich: 7
Ulm: 16
GREECE
Athens: 12
ITALY
Camerino: 24
JAPAN
Fukushima: 2
Iwate: 2
Kanagawa: 2, 26
Osaka: 26
Sapporo: 9
Sendai: 26
Tokyo: 9, 20
Tsukuba: 2
Yokohama: 9
KOREA
Daejeon: 5
Seoul: 25
NETHERLANDS
Nijmegen: 11
SLOVENIA
Ljubljana: 29
SPAIN
Barcelona: 12
SWITZERLAND
Lausanne: 14
Zurich: 19
UNITED KINGDOM
Bournemouth: 12
Cambridge: 29
Oxford: 12
Salisbury: 12
Southampton: 12, 16
UNITED STATES OF AMERICA
California
Berkeley: 18
Los Angeles: 21
Stanford: 22
Colorado
Boulder: 24
Connecticut
New Haven: 23
Georgia
Athens: 27
Atlanta: 27
Illinois
Urbana: 16
Maryland
Baltimore: 10
Gaithersburg: 26
Massachusetts
Boston: 1, 22, 23, 25, 28
Cambridge: 1
Michigan
Kalamazoo: 6
Minnesota
Minneapolis: 13
New York
New York: 1, 3, 4, 17, 21, 25
North Carolina
Winston-Salem: 10
Pennsylvania
Philadelphia: 28
Rhode Island
Providence: 2
Virginia
Ashburn: 17
Charlottesville: 26
Washington
Pullman: 8
PRESS CONTACTS…
For media inquiries relating to embargo policy for all the Nature Research Journals:
Rachel Twinn (Nature London)
Tel: +44 20 7843 4658
E-mail: [email protected]
Neda Afsarmanesh (Nature New York)
Tel: +1 212 726 9231
E-mail: [email protected]
Ruth Francis (Head of Press, Nature, London)
Tel: +44 20 7843 4562
E-mail: [email protected]
For media inquiries relating to editorial content/policy for the Nature Research Journals, please contact the journals individually:
Nature Biotechnology (New York)
Michael Francisco
Tel: +1 212 726 9288
E-mail: [email protected]
Nature Cell Biology (London)
Sowmya Swaminathan
Tel: +44 20 7843 4656
E-mail: [email protected]
Nature Chemical Biology (Boston)
Sarah Daniels
Tel: +1 617 475 9241
E-mail: [email protected]
Nature Chemistry (London)
Stuart Cantrill
Tel: +44 20 7014 4018
E-mail: [email protected]
Nature Genetics (New York)
Myles Axton
Tel: +1 212 726 9324
E-mail: [email protected]
Nature Geoscience (London)
Heike Langenberg
Tel: +44 20 7843 4042
E-mail: [email protected]
Nature Immunology (New York)
Laurie Dempsey
Tel: +1 212 726 9372
E-mail: [email protected]
Nature Materials (London)
Vincent Dusastre
Tel: +44 20 7843 4531
E-mail: [email protected]
Nature Medicine (New York)
Juan Carlos Lopez
Tel: +1 212 726 9325
E-mail: [email protected]
Nature Methods (New York)
Hugh Ash
Tel: +1 212 726 9627
E-mail: [email protected]
Nature Nanotechnology (London)
Peter Rodgers
Tel: +44 20 7014 4019
Email: [email protected]
Nature Neuroscience (New York)
Kalyani Narasimhan
Tel: +1 212 726 9319
E-mail: [email protected]
Nature Photonics (Tokyo)
Oliver Graydon
Tel: +81 3 3267 8776
E-mail: [email protected]
Nature Physics (London)
Alison Wright
Tel: +44 20 7843 4555
E-mail: [email protected]
Nature Structural & Molecular Biology (New York)
Sabbi Lall
Tel: +1 212 726 9326
E-mail: [email protected]
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