This press release contains:
---Summaries of newsworthy papers:
Geoscience: The ocean’s role in North Atlantic storminess
Methods: Imaging sugars in live animals
Chemical Biology: Reversible covalent inhibitors
---Mention of papers to be published at the same time with the same embargo
---Geographical listing of authors
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[1] Geoscience: The ocean’s role in North Atlantic storminess
DOI: 10.1038/ngeo1438
The response of the North Atlantic storm track to human-induced greenhouse gas emissions is strongly affected by changes in ocean circulation, reports a study published online this week in Nature Geoscience. The findings indicate that a better understanding of the ocean circulation would help reduce uncertainties in the future evolution of the North Atlantic storm track — which has been projected to extend further towards western Europe.
Tim Woollings and colleagues analysed an ensemble of coupled climate model simulations for the twenty-first century. They found that the strengthening and eastward extension of the North Atlantic storm track in response to human-induced greenhouse gas emissions — markedly different from the poleward shift of storm tracks in other regions — is shaped by changes in the Atlantic overturning circulation. They conclude that the oceanic overturning circulation is closely linked to the North Atlantic storm track.
Author contact:
Tim Woollings (University of Reading, UK)
Tel: +44 118 378 6517; E-mail: [email protected]
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[2] Methods: Imaging sugars in live animals
DOI 10.1038/nmeth.1945
A technique for visualizing specific sugars in living worms which provides insight into their biological function is published online this week in Nature Methods.
Visualization of non-genetically encoded molecules, such as sugars or lipids, within living organisms is challenging but important to understand the essential role these molecules play in development and disease. In the past scientists have used chemical compounds to attach a fluorescent dye to sugars, but this is a non-specific approach since it labels all sugars, irrespective of their modifications.
Hannes Bülow and his colleagues are especially interested in such modified sugars, particularly in heparan sulfates – linear polysaccharides displayed on the outside of a cell whose modification pattern determines their biological function. To follow particular heparan sulfates through the course of a worm’s development, the authors fused antibodies, that recognize the specific modifications on the sugar, to GFP (Green fluorescent protein) together with a secretion signal that ensured export of the antibodies to the outside of the cell where they bound their targets. The scientists identified the cell types that displayed the heparan sulfates at each key developmental stage.
This approach has the potential to easily be extended to other sugars, lipids or proteins with post translational modifications as long as specific antibodies for the modification exist.
Author contact:
Hannes Bülow (Albert Einstein College of Medicine, New York, NY, USA)
Tel: +1 718 4303621; E-mail: [email protected]
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[3] Chemical Biology: Reversible covalent inhibitors
DOI: 10.1038/nchembio.925
An unexpected chemical approach for engineering compounds that interact with their target via a reversible covalent mechanism is reported this week in Nature Chemical Biology.
Covalent drugs – which are used to treat many diseases including cancer – often interact with a particular amino acid residue in protein targets in a highly specific fashion and are irreversible so they can yield long-lasting effects. Some classes of covalent drugs are known to react with proteins in cells that are not the intended target, and these “off-target” interactions are also long lasting and can have detrimental consequences.
Jack Taunton and colleagues report a chemical approach to convert one common class of covalent drugs called acrylamides into reversible inhibitors. They demonstrate the utility of this approach by converting an irreversible covalent inhibitor for the kinase RSK2—important for cell division, growth and survival—into a reversible inhibitor. This chemical strategy may retain the specificity advantages gained through the covalent targeting of a certain amino acid residue while decreasing the potential negative consequences of irreversible off-target drug activity.
Author contact:
Jack Taunton (University of California at San Francisco, CA, USA)
Tel +1 415 514 2004; E-mail [email protected]
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Items from other Nature journals to be published online at the same time and with the same embargo:
Nature (http://www.nature.com/nature)
[4] A novel ChREBP isoformin adipose tissue regulates systemic glucose metabolism
DOI: 10.1038/nature10986
[5] Sexual selection enables long-term coexistence despite ecological equivalence
DOI: 10.1038/nature10971
[6] Pathogen-induced human TH17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta
DOI: 10.1038/nature10957
NATURE CELL BIOLOGY (http://www.nature.com/naturecellbiology)
[7] SPEECHLESS integrates brassinosteroid and stomata signalling pathways
DOI: 10.1038/ncb2471
NATURE CHEMICAL BIOLOGY (http://www.nature.com/nchembio)
[8] A combinatorial TIR1/AFB-Aux/IAA co-receptor system for differential sensing of auxin
DOI: 10.1038/nchembio.926
NATURE CHEMISTRY (http://www.nature.com/nchem)
[9] Ion-paired chiral ligands for asymmetric palladium catalysis
DOI: 10.1038/nchem.1311
[10] Multiphase design of autonomic self-healing thermoplastic elastomers
DOI: 10.1038/nchem.1314
NATURE CLIMATE CHANGE (http://www.nature.com/nclimate)
[11] Role of pH up-regulation in the resilience of coral calcification to ocean acidification and global warming
DOI: 10.1038/nclimate1473
[12] 135 years of global ocean warming between the Challenger expedition and the Argo Programme
DOI: 10.1038/nclimate1461
NATURE GENETICS (http://www.nature.com/naturegenetics)
[13] Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis
DOI: 10.1038/ng.2221
[14] Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair
DOI: 10.1038/ng.2228
[15] Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair
DOI: 10.1038/ng.2229
[16] UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair
DOI: 10.1038/ng.2230
NATURE GEOSCIENCE (http://www.nature.com/ngeo)
[17] Terrestrial carbon isotope excursions and biotic change during Palaeogene hyperthermals
DOI: 10.1038/ngeo1427
NATURE IMMUNOLOGY (http://www.nature.com/natureimmunology)
[18] Intrathymic programming of effector fates in three molecularly distinct gamma-delta T cell subtypes
DOI: 10.1038/ni.2247
[19] Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks
DOI: 10.1038/ni.2262
[20] The development and fate of follicular helper T cells defined by an IL-21 reporter mouse
DOI: 10.1038/ni.2261
NATURE MATERIALS (http://www.nature.com/naturematerials)
[21] Sparsity-based single-shot subwavelength coherent diffractive imaging
DOI: 10.1038/nmat3289
[22] Gradient-index meta-surfaces as a bridge linking propagating waves and surface waves
DOI: 10.1038/nmat3292
Nature MEDICINE (http://www.nature.com/naturemedicine)
[23] Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia
DOI: 10.1038/nm.2709
[24] RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing
DOI: 10.1038/nm.2693
[25] Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer
DOI: 10.1038/nm.2700
NATURE METHODS (http://www.nature.com/nmeth)
[26] Integrated genetic and computation methods for in planta cytometry
DOI: 10.1038/nmeth.1940
[27] Quantitative fluorescent labeling of aldehyde-tagged proteins for single-molecule imaging
DOI: 10.1038/nmeth.1954
[28] Segregation of molecules at cell division reveals native protein localization
DOI: 10.1038/nmeth.1955
NATURE NANOTECHNOLOGY (http://www.nature.com/nnano)
[29] A nanomechanical mass sensor with yoctogram resolution
DOI: 10.1038/nnano.2012.42
[30] The emergence of multifrequency force microscopy
DOI: 10.1038/nnano.2012.38
Nature NEUROSCIENCE (http://www.nature.com/natureneuroscience)
[31] Oscillatory dynamics in the hippocampus support dentate gyrus–CA3 coupling
DOI: 10.1038/nn.3081
[32] An evolutionary recent cell adhesion function for huntingtin in neuroepithelial cells implicates ADAM10-Ncadherin
DOI: 10.1038/nn.3080
Nature PHYSICS (http://www.nature.com/naturephysics)
[33] Phonon-cavity electromechanics
DOI: 10.1038/nphys2277
[34] Experimental observation of the optical spin transfer torque
DOI: 10.1038/nphys2279
Nature STRUCTURAL & MOLECULAR BIOLOGY (http://www.nature.com/natstructmolbiol)
[35] Discovery of an archetypal protein transport system in bacterial outer membranes
DOI: 10.1038/nsmb.2261
[36] NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway
DOI: 10.1038/nsmb.2269
[37] p53-mediated heterochromatin reorganization regulates its cell fate decisions
DOI: 10.1038/nsmb.2271
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GEOGRAPHICAL LISTING OF AUTHORS
The following list of places refers to the whereabouts of authors on the papers numbered in this release. The listing may be for an author's main affiliation, or for a place where they are working temporarily. Please see the PDF of the paper for full details.
ARGENTINA
Buenos Aires: 7
AUSTRALIA
Brisbane: 35
Clayton: 35
Crawley: 11
Parkville: 20, 35
Sydney: 26
AUSTRIA
Laxenburg: 5
Vienna: 7
BELGIUM
Ghent: 7
BULGARIA
Sofia: 7
CANADA:
Toronto: 13
Vancouver: 5
CHINA
Shanghai: 22
CZECH REPUBLIC
Prague: 34
DENMARK
Copenhagen: 3
FRANCE
Evry: 13
Gif-sur-Yvette: 11
Montpellier: 26
Paris: 13
GERMANY
Berlin: 24
Cologne: 1
Darmstadt: 32
Halle: 8
Heidelberg: 26
Jena: 21
Karlsruhe: 4
Leipzig: 4
GREECE
Athens: 16
ISRAEL
Haifa: 21
Tel Aviv: 15
ITALY
Bologna: 11
Genoa: 6
Milan: 25, 32
Pavia: 15
JAPAN
Hiroshima: 14
Kanagawa: 33
Kumamoto: 15
Nagasaki: 15
Nagoya: 9
Odawara: 15
Osaka: 14
Sendai: 14
Tokyo: 14, 15
NETHERLANDS
Nijmegen: 2
Rotterdam: 16
Utrecht: 17, 25
Wageningen: 7
PORTUGAL
Lisbon: 31, 32
SPAIN
Barcelona: 29
Madrid: 30
SWITZERLAND
Bellinzona: 6
Zurich: 6
TAIWAN
Taipei: 22
UNITED KINGDOM
Brighton: 15
Cambridge: 26, 34
Dundee: 26
Edgbaston: 35
Exeter: 1
Glasgow: 35
Leeds: 8
Liverpool: 8
London: 31
Nottingham: 34
Reading: 1
Southampton: 12
UNITED STATES OF AMERICA
California
Berkeley: 5
Irvine: 10
La Jolla: 8, 12
Pasadena: 36
Richmond: 25
San Francisco: 3
Stanford: 31
Colorado
Colorado Springs: 17
Illinois
Urbana: 27
Indiana
West Lafayette: 17
Iowa
Iowa City: 3
Maryland
Baltimore: 13
Chevy Chase 3, 36
Massachusetts
Amherst: 28
Boston: 4, 8, 14, 18, 19, 28, 32
Cambridge: 19, 28
Charlestown: 24, 37
Worcester: 18
Michigan
Ann Arbor: 17, 37
Missouri
St Louis: 4
New Hampshire
Durham: 17
New Jersey
Piscataway: 23
New York
Bronx: 2
New York: 3, 37
Palisades: 11
North Carolina
Chapel Hill: 13
Ohio
Cleveland: 13
Pennsylvania
University Park: 18
Virginia
Charlottesville: 32
Washington
Seattle: 8, 25
Wisconsin
Madison: 24
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PRESS CONTACTS…
For media inquiries relating to embargo policy for all the Nature Research Journals:
Rachel Twinn (Nature London)
Tel: +44 20 7843 4658; E-mail: [email protected]
Neda Afsarmanesh (Nature New York)
Tel: +1 212 726 9231; E-mail: [email protected]
Eiji Matsuda (Nature Tokyo)
Tel: +81 3 3267 8751; E-mail: [email protected]
For media inquiries relating to editorial content/policy for the Nature Research Journals, please contact the journals individually:
Nature Biotechnology (New York)
Michael Francisco
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Nature Cell Biology (London)
Sowmya Swaminathan
Tel: +44 20 7843 4656; E-mail: [email protected]
Nature Chemical Biology (Boston)
Elissa Bolt
Tel: +1 617 475 9241, E-mail: [email protected]
Nature Chemistry (London)
Stuart Cantrill
Tel: +44 20 7014 4018; E-mail: [email protected]
Nature Climate Change (London)
Rory Howlett
Tel: +44 20 7014 4009; E-mail: [email protected]
Nature Genetics (New York)
Myles Axton
Tel: +1 212 726 9324; E-mail: [email protected]
Nature Geoscience (London)
Heike Langenberg
Tel: +44 20 7843 4042; E-mail: [email protected]
Nature Immunology (New York)
Laurie Dempsey
Tel: +1 212 726 9372; E-mail: [email protected]
Nature Materials (London)
Vincent Dusastre
Tel: +44 20 7843 4531; E-mail: [email protected]
Nature Medicine (New York)
Juan Carlos Lopez
Tel: +1 212 726 9325; E-mail: [email protected]
Nature Methods (New York)
Ray Parker
Tel: +1 212 726 9627; E-mail: [email protected]
Nature Nanotechnology (London)
Peter Rodgers
Tel: +44 20 7014 4019; Email: [email protected]
Nature Neuroscience (New York)
Kalyani Narasimhan
Tel: +1 212 726 9319; E-mail: [email protected]
Nature Photonics (Tokyo)
Oliver Graydon
Tel: +81 3 3267 8776; E-mail: [email protected]
Nature Physics (London)
Alison Wright
Tel: +44 20 7843 4555; E-mail: [email protected]
Nature Structural & Molecular Biology (New York)
Michelle Montoya
Tel: +1 212 726 9331; E-mail: [email protected]
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