NATURE AND THE NATURE RESEARCH JOURNALS PRESS RELEASE
For papers that will be published online on 30 April 2006. This press release is copyrighted to the Nature journals mentioned below.
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Sensing bacterial infection – Nature Immunology
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*****************************NATURE IMMUNOLOGY ***************************
(http://www.nature.com/natureimmunology)
[4], [5] & [6] Sensing bacterial infection
DOI: 10.1038/ni1336
DOI: 10.1038/ni1344
DOI: 10.1038/ni1346
New information on the complex interplay between host cells and bacteria during infection is reported in the June issue of Nature Immunology. Three studies provide a new understanding of the relationship between salmonella bacteria and the cells infected.
Host cells use special ‘sensors’ to detect unique components of invading bacteria and alert the rest of the body to the infection by triggering inflammation. Bacteria produce flagellin, a protein that bundles together to form the flagellum, a tail that allows bacteria to swim.
Teams led by Alan Aderem and Gabriel Nunez find that when salmonella bacteria infect a host cell, flagellin released from the bugs is detected by a sensor that triggers inflammation. In a complementary study, work from Ayub Qadri’s laboratory shows that host cells produce a lipid that ‘tricks’ salmonella into secreting flagellin so that the bugs can be detected by the host sensor, triggering an immune response. These studies provide exciting new details of how bacteria cause inflammation and how host cells are actively involved in that process.
Author contacts:
Ayub Qadri (National Institute of Immunology, New Delhi, India)
Tel: +91 11 26703733; E-mail: [email protected]
Alan Aderem (Institute for Systems Biology, Seattle, WA, USA)
Tel: +1 206 732 1203; E-mail: [email protected]
Gabriel Nunez (University of Michigan, Ann Arbor, MI, USA)
Tel: +1 734 764 8514; E-mail: [email protected]
Other papers from Nature Immunology to be published online at the same time and with the same embargo:
[7] Quantitative proteomic analysis of B cell lipid rafts reveals that ezrin regulates antigen receptor–mediated lipid raft dynamics
DOI: 10.1038/ni1337
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