Synthesis and application of caffeic acid-modified gelatin hydrogel for inner retinal tissue repair.
In this study, a research team from National Taiwan University and its affiliated hospital developed an injectable hydrogel specifically engineered for retinal repair.
The hydrogel is based on gelatin modified with natural polyphenols, which enhance its antioxidative capacity and tissue adhesion. The material is highly transparent, biocompatible, and capable of remaining stably attached to the inner retinal surface after injection.
It creates a supportive microenvironment that mitigates oxidative stress and inflammation—two major contributors to retinal degeneration. In vivo validation confirmed its safety and efficacy, demonstrating preservation of retinal architecture and reduced cellular damage.
“This platform also holds promise as a scaffold for stem cell delivery, offering a novel approach to retinal tissue engineering and future regenerative therapies,” said Prof. Jiashing Yu.
“We hope this new treatment modality can benefit patients suffering from optic neuropathies and retinal injuries,” added Prof. Ta-Ching Chen.
Prof. Ta-Ching Chen｜email address: [email protected]
Prof. Jiashing Yu｜email address: [email protected]
