Chemistry Nanotechnology

Researchers at The University of Osaka have developed a method to reproducibly form subnanometer pores within a solid-state nanopore. A voltage-driven chemical reaction produces a precipitate that fills and closes the nanopore, while dissolution reopens conductive pathways. This process forms many subnanometer-sized pores, whose effective size can be tuned by changing reactant composition and pH. These ultrasmall pores mimic biological ion channels and enable studies of ion transport in confined spaces.

Mixing two or three liquids can achieve the right combination of functions for soft electronics.

Scientists at the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, have captured real-time images showing how a key brain enzyme organizes itself to help memory formation. Their study, published in Nature Communications, reveals that the enzyme CaMKII forms mixed α/β subunit structures whose interactions stabilize learning-related signals in neurons.

Researchers from The University of Osaka fabricated a nanopore surrounded by a gate as a cooling system with enhanced efficiency for semiconductor chips. Applying a voltage to the gate induces the flow of ions through the nanopore. Creating a salt gradient makes the ion flow unidirectional. Heat is dragged along with the ions, resulting in heat transfer. Changing the applied voltage from negative to positive switches the system from cooling to heating.

A collaboration team of researchers from the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, the Institute of Transformative Bio-Molecules (WPI-ITbM), Graduate School of Science at Nagoya University, and the RIKEN Center for Computational Science (R-CCS) reports in ACS Nano an integrative modeling workflow to understand with atomistic precision biomolecular dynamics from high-speed atomic force microscopy experiments.

A new nanoparticle capable of carrying much higher doses of drugs while staying stable for extended periods could make treatments more effective

Researchers at the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, report in Small, a weekly peer-reviewed scientific journal covering nanotechnology, published by Wiley-WCH, Germany, how short peptides self-assemble linearly on atomically-thick solid surfaces, such as graphite and MoS₂. The research addresses a longstanding challenge in materials science: understanding the complex, sequence-specific interactions between peptides and solid substrates, and the critical role of local hydration structures in guiding nanoarchitecture formation. This work offers new strategies for integrating biomolecules with advanced materials in future bioelectronics and sensor devices.

Portable technology offers instant, power-free ethanol detection across concentrations

The power conversion efficiency of all-organic solar cells was doubled through the development of novel organic electrodes that can be fabricated using a moderate process.

Shin-Etsu Chemical and Hokkaido University have developed system for the production of lipid nanoparticles (LNPs) that incorporates a microfluidic device.

The team’s findings have potential applications in photonics and memory devices.

Redefining the art of matter manipulation at the nanoscale

Nanostructured two-dimensional gold monolayers offer possibilities in catalysis, electronics, and nanotechnology.

Light-induced immunoassay coated with novel coronavirus spike proteins found highly sensitive even with weak light like a laser pointer

Researchers at the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, develop a biosensor that improves sensitivity to 1-methylnicotinamide (1-MNA) in urine by orders of magnitude without the need for sample purification.

New filter removes chemical contaminants from water even at very low concentrations

Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, IMDEA Nanoscience (Madrid, Spain) and CNB-CSIC (Madrid, Spain) report in ACS Nano experiments that reveal a cycle of conformational stages that recombinant Influenza A genomes pass through during RNA synthesis.

Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University report in Biosensors and Bioelectronics: X a novel approach for detecting a particular biomolecule associated with several diseases. The results show good sensitivity and selectivity, and may lead to the development of a low-cost, rapid detection device useful in cancer prognosis.

Researchers from Nano Life Science Institute (WPI-NanoLSI), Kanazawa University report in Nature Communications that TMEM16F, a transmembrane protein that facilitates the passive movement of phospholipids and ions across membranes, explores a larger conformational landscape than previously thought to perform its unique functions. The finding refines our molecular understanding of crucial physiological processes such as blood coagulation and COVID-19 pathogenesis, and highlights the importance of probing membrane proteins in native-like environments.

Friction, an everyday phenomenon, has perplexed scientists for centuries. Though extensively researched, our　understanding remains fragmented, primarily due to the multifaceted interactions that span across varying scales.　Achieving an accurate grasp of the precise contact conditions between objects has been a longstanding challenge, a feat recently made possible through advancements in scanning probe microscopy.

An international team led by Professor Yan Xu from Osaka Metropolitan University has developed a groundbreaking nanofluidic device, named NANa, capable of stochastically capturing and digitally detecting individual proteins at cellular concentrations. This tool, vital for precision medicine, is designed to handle tiny volumes equivalent to a single cell's contents and can identify single biomolecules even in high-concentration environments. The team plans to conduct further demonstrations using actual cell samples and explore the integration of this tool with AI and biological big data. This research could potentially revolutionize personalized disease prevention and treatment.

A joint research group at Osaka Metropolitan University has succeeded in regulating the flow of single molecules in solution by opening and closing the nanovalve mounted on the nanofluidic device by applying external pressure. The research group fabricated a device with a ribbon-like, thin, soft glass sheet on the top, and at the bottom a hard glass substrate having nanochannels and nanovalve seats. By applying external pressure to the soft glass sheet to open and close the valve, they succeeded in directly manipulating and controlling the flow of individual molecules in solution. They also observed an effect of fluorescence signal amplification when single fluorescent molecules are confined in the tiny nanospace inside the valve. The effect can be ascribed to the nanoconfinement, which suppresses the random motion of the molecules.

Researchers at Kanazawa University report in JACS Au how they have developed operando scanning ion conductance microscopy to allow simultaneous measurements of changes in the anode surface topography of a lithium ion battery during use, as well as the varying ion concentration with depth. Combining both types of information should help researchers evaluate the correlation between the two to design better batteries.

Researchers at Kanazawa University report in ACS Nano how high-speed atomic force microscopy can be used to study the biomolecular mechanisms underlying gene editing.

Researchers at Kanazawa University report in Nano Letters the discovery of a biomolecular dynamical process likely relevant to gene expression. The process, revealed by means of high-speed atomic force microscopy, involves DNA and its packaging molecules.

Researchers from Osaka Metropolitan University have developed principles and technologies of nanofluidic devices to freely manipulate nanomaterials, biomaterials, and molecules at the single-molecule level using fundamental technologies such as nanofluidic processing, functional integration, and fluidic control and measurement, which has pioneered the way to integrate various fields under nanofluidics.

A research group, at the Osaka Metropolitan University Graduate School of Engineering, has succeeded in measuring spin transport in a thin film of αNPD molecules—a material well-known in organic light emitting diodes—at room temperature. They found that this thin molecular film has a spin diffusion length of approximately 62 nm, a length that could have practical applications in developing spintronics technology. In addition, while electricity has been used to control spin transport in the past, the thin molecular film used in this study is photoconductive, allowing spin transport control using visible light.

Researchers at The University of Tokyo show how including the effects of the surrounding water during the aggregation of charged particles can improve the accuracy of simulations, which may help elucidate biological self-assembly

A Hong Kong Baptist University (HKBU) collaborative research team has synthesised a nanoparticle named TRZD that can perform the dual function of diagnosing and treating glioma in the brain. It emits persistent luminescence for the diagnostic imaging of glioma tissues in vivo and inhibits the growth of tumour cells by aiding the targeted delivery of chemotherapy drugs. The nanoparticle offers hope for the early diagnosis and treatment of glioma, especially cerebellar glioma, which is even harder to detect and cure with existing methods.

A research group at Osaka Metropolitan University has developed a drug delivery system that activates a strong cellular immune response to attack cancer cells, using one-tenth of the amount of antigen needed in the group’s previous work. By incorporating positively charged cationic lipids into liposomes and adding negatively charged pH-responsive polysaccharides to the surface, the research group increased the uptake efficiency of liposomes encapsulating cancer antigens by dendritic cells by approximately five times, which increased cytokine production by about 100 times. This increased M1-type macrophages, which activate cancer immunity, and decreased M2-type macrophages, which promote cancer growth.