A multidisciplinary team of robotics and electronic systems engineers working with cardiologists and materials scientists has developed a robotic apparatus that uses an external magnetic field to precisely and remotely control guidewires through tiny and tortuous blood vessels. The team, led by researchers at Daegu Gyeongbuk Institute of Science and Technology (DGIST), reported their results in the journal Advanced Healthcare Materials.
The apparatus, following further tests and commercialization, could minimize the exposure of physicians to X-ray radiation while looking for and treating narrowed or blocked blood vessels.
“Cardiovascular diseases are the leading cause of death worldwide, and it is very important to be able to diagnose and treat these diseases in the most minimally invasive way possible,” says DGIST robotics engineer Hongsoo Choi.
Currently, percutaneous coronary intervention (PCI) involves introducing a guidewire through the large femoral artery in the groin or the radial artery in the wrist and expertly manipulating it until it reaches the largest blood vessel in the body, the aorta. A contrast agent is then injected into the aorta, where it spreads into the coronary arteries that feed the heart. X-ray images are then taken to pinpoint any blockages present in these arteries. This intervention requires a huge amount of skill and can still lead to vessel perforation. It also involves unnecessary exposure of the physician to X-ray radiation, as the procedure is conducted at the patient’s bedside.
In recent years, researchers have been investigating the use of robotic magnetic systems to improve the remote control of this sort of procedure. But the systems that have been developed are ºften bulky and do not respond quickly enough.
Now, Choi and his team have developed a system that involves remotely controlling a magnetically steerable microrobotic guidewire by applying a controllable external magnetic field. The field is generated by a system made of eight electromagnets arranged in a hemispherical configuration under a surgical bed. The patient is meant to be placed on the bed, with the guidewire inserted into an artery and guided remotely by changing the magnetic field. The guidewire is made of a biocompatible silicone tube that can move through blood vessels with very little surface friction. The tip of the microrobotic tube encapsulates a neodymium-iron-boron permanent magnet and hard-magnetic composites for magnetic steering.
The researchers first tested the system using 2D- and 3D-printed blood vessel models. They then tested it in anaesthetized pigs, managing to remotely control the guidewires through small and tortuous arteries in the pelvis, kidneys and heart.
“Our proposed electromagnetically controllable microrobotic interventional system (ECMIS) could reduce radiation exposure of physicians by empowering them to conduct the procedure remotely in an X-ray shielded control booth using low-strength magnetic fields,” says Choi. “It also does not require the high level of training needed for conducting conventional PCIs.”
More tests and improvements are still required, but the researchers are already planning to further modify their apparatus so it can also target vessels in the nervous system and lungs.
Did you know?
Heart disease was the leading cause of death in Asia in 2019. Heart disease deaths in numbers: 18.6 millions globally; 10.8 millions in Asia. The number in Asia rose from 5.6 million to 10.8 million between 1990 and 2019.
Source: Zhao D, et al. Epidemiological Features of Cardiovascular Disease in Asia. JACC: Asia. 2021 Jun, 1 (1) 1–13. https://doi.org/10.1016/j.jacasi.2021.04.007