Studying the geometry of a common skin disease

In a recent study from Hiroshima University, researchers turned to mathematics to predict hive patterns in humans.

The wheals (hives) were mapped.

Hives afflict 1 in 5 people, but the exact mechanisms behind the itchy red rashes are not well known.


The research team studied the patterns of hives in patients and reproduced the hive patterns using a mathematical model called a reaction-diffusion model, a common prototype for understanding how patterns develop. The researchers' model is a single equation type which had never before been used to generate complex patterns.

In response to injury, allergens, or stress, hives can form when cells called mast cells in the skin release a compound called histamine. The red swollen mark (also known as wheals) can range from a few millimeters to the size of a hand or even larger.

While research has shown that histamine itself helps mast cells release histamine, this study considers for the first time that certain mechanisms might also inhibit histamine release and that there may be more going on behind the disease than previously thought.

"Our model succeeded in creating complex pattern of urticaria (hives), which is a very surprising result from both mathematical and biological points of views," said lead author and Associate Professor Sungrim Seirin-Lee.

To create the equation, the researchers gave rashes to eight healthy volunteers and measured the time it took for the rash to form and determined the velocity of formation. The team then looked at 14 patients with urticaria and measured them using the same model as the healthy patients.

Rather than relying solely on biological studies to investigate hives, which often requires inducing hives in patients, the mathematical focus provides a new avenue for skin disease research. In the future, the mathematical model could possibly be used as a tool to find the molecules which play a role in the inhibition process, as well.

"Finding the mechanism of urticaria is difficult only by biological methods," said Seirin-Lee. "Thus, we tried a completely different approach, mathematics. The approach using mathematical model for urticaria is the first trial in the world."

Ultimately, the findings from the study will help put together a more detailed picture of how the common skin disease develops and how to effectively deliver treatments.

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Contact:
S. Seirin-Lee
Department of Mathematical and Life Sciences, Graduate School of Integrated Science for Life,
Hiroshima University, Kagamiyama 1-3-1, Higashi-Hiroshima 739-8526, Japan
Tel: +81-82-424-7394 Fax: +81-82-424-7394
Email: [email protected]
Website: https://sites.google.com/site/seirin711lee/home

Michihiro Hide
Division of Molecular Medical Science,
Department of Dermatology,
Graduate School of Biomedical Sciences,
Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan
Tel: +81-82-257-5235 Fax: +81-82-257-5239
Email: [email protected]

Since its foundation in 1949, Hiroshima University has strived to become one of the most prominent and comprehensive universities in Japan for the promotion and development of scholarship and education. Consisting of 12 schools and 11 graduate schools, ranging from International Development and Cooperation to Integrated Arts and Sciences, the university has grown into one of the most distinguished research universities in Japan. English website: https://www.hiroshima-u.ac.jp/en

Published: 28 Jan 2020

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Reference: 

Seirin-Lee S, Yanase Y, Takahagi S, Hide M (2020) A single reaction-diffusion equation for the multifarious eruptions of urticaria. PLoS Comput Biol 16(1): e1007590. https://doi.org/10.1371/journal.pcbi.1007590

Funding information: 
This work was supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology (JSPS), Japan and the JST PRESTO programme, Japan.