Japan

Researchers at the Nano Life Science Institute (WPI-NanoLSI) at Kanazawa University, Kyoto University, SOKENDAI, and the National Institute for Physiological Sciences have revealed how a key brain protein involved in learning and memory organizes itself into chain-like structures. Their study was published in Science Advances.

A research team led by the University of Osaka created porous crystals that grow into spring-like helices. The crystals expand and contract as solvent molecules leave and re-enter their pores. The work shows that crystallization conditions can tune the overall shape of a porous crystal without fundamentally changing its internal porous structure, opening possibilities for microscale materials that respond to chemicals.

A team led by researchers from the University of Osaka has revealed the first structure of an umami taste receptor. They found that the pufferfish receptor can sense many more amino acids than the human receptor, including some linked to flavors humans detect as sweet. This helps the fish to detect more types of savory chemicals in their food. The research also shows how the receptor’s structure makes this flexibility possible. The findings could help develop new umami flavors.

How are extra-long genes read? A novel mechanism in which RNA-scaffolded nuclear condensates gather diverse factors to coordinate gene expression

For decades, scientists have understood proteins primarily through two defining features: their amino acid sequence and their three-dimensional structure. This framework has driven major advances in biology, biotechnology, and medicine, culminating in recent artificial intelligence tools capable of predicting protein structures with remarkable accuracy. Yet a fundamental challenge remains: even when a protein's sequence and structure are known, predicting its function, interactions, and behavior often remains difficult. An international team of researchers from Japan, Finland, Italy, and the United States now reports evidence that part of this missing information may lie in an often-overlooked component of proteins: the highly organized water surrounding them. In a study accepted for publication in Nature Communications, the team provides the first direct three-dimensional visualization of sequence-dependent hydration architectures surrounding peptide assemblies at sub-nanometer resolution using advanced three-dimensional atomic force microscopy (3D-AFM) (Fig.1).

A team led by the University of Osaka researchers discovered that cells producing IgG1 antibodies multiply more, are less prone to cell death in the spleen, and migrate more efficiently to the bone marrow, where long-lived antibody-producing cells can become established. Understanding how these cells gain these advantages could help researchers design vaccines that provide longer-lasting protection against infection.

Researchers at the University of Osaka discovered FoeAB, a previously unknown bacterial pump that exports the antibiotic fosfomycin. By combining transport experiments with cryo-electron microscopy, the team revealed how the protein recognizes and moves the drug across the cell membrane. The findings expand understanding of antibiotic efflux in Gram-positive bacteria and could support new strategies to counter drug resistance and improve treatment of bacterial infections.

Researchers at the University of Osaka discovered a simple, rigid aromatic hydrocarbon that breaks the usual rule. Under pressure, its crystals grow 1.7 times brighter and shift color from light blue to yellow, with a record-high sensitivity of 37.4 nm/GPa, nearly double the previous best. An elongated, uniformly slender molecular shape was the key, offering a new design principle for pressure-responsive materials without complex flexible frameworks.

A new study shows that the Pt/C catalyst state before ionomer addition governs later ink dispersion and electrochemical Pt accessibility.

Mapping interacting galaxies reveals how turbulence can suppress star formation

Researchers led by the University of Osaka developed a reusable light-responsive adhesive that switches adhesion at the interface instead of weakening the whole material. UV-A light reduces interfacial adhesion, enabling selective peeling without observable residue, while UV-C light restores adhesion. The response was retained through repeated cycles without solvent processing. The approach could simplify disassembly, repair, and recycling of electronics, vehicles, and semiconductor components, supporting more circular manufacturing across industries.

A study in budding yeast suggests that changes in membrane lipids trigger a braking system that slows internal protein transport when the endoplasmic reticulum comes under stress, comparable to modern logistics networks where shipments are slowed when distribution hubs are under stress.

A team led by researchers from the Institute of Industrial Science, The University of Tokyo shows that controlling the spin of hydrogen atoms can regulate chemical reactions

Isotopes of atmospheric water leave fingerprints that can improve weather modelling

Researchers at the University of Osaka used cyclic PPS manufacturing by-products as movable molecular crosslinks in biodegradable PCL. Medium-sized c [7] PS rings approximately doubled toughness while slowing enzymatic degradation, whereas larger c [9] PS rings accelerated degradation to no residual film mass after 48 hours. The findings identify molecular ring size as a design parameter for tuning material lifetime while also offering a waste-to-value route toward more sustainable polymer systems with programmable properties.

A nationwide Japanese birth cohort study of 101,864 children found that ovulation induction, intrauterine insemination and in vitro fertilization were associated with a higher risk of Kawasaki disease before age five compared with spontaneous conception. Intracytoplasmic sperm injection showed no clear difference in risk. The findings remained broadly consistent after adjustment for maternal comorbidities and highlight the need for further research into underlying mechanisms.

Subducted Carbonates Drive Deep Carbon Cycling and Reshape Mantle Discontinuity Structure

Validating artificial intelligence performance in radiology studies with demographic subgroups

A research group in Japan led by Professor YAMAMOTO Takashi, Deputy Director, Center for Quantum Information and Quantum Biology / Graduate School of Engineering Science, the University of Osaka, in collaboration with the National Institute of Information and Communications Technology (NICT) and Hamamatsu Photonics K.K., has successfully demonstrated a world-record 10-channel multiplexed quantum photonic interface based on an integrated waveguide array, a key technology for optically interconnecting multiple quantum computers.

Instead of producing graphene at temperatures as high as 900°C, researchers at Tohoku University found a way to lower this to 300 °C. Even better, the material used to achieve this can be easily obtained from industrial waste.

Think you could learn a brand new skill from a five-second video clip? AI was trained on footage from just a few steps of a stick insect, and learned how to walk, navigate bumpy terrain, and adapt to limb loss in a robot with six legs.

Researchers from the University of Osaka found that amyloid formation is promoted by a combination of shear stress and constrained geometry in an in vitro model of amyloidogenic light chain disease. Applying mechanical agitation or pressure, as well as disaggregating agents, effectively removed amyloid deposits. These findings provide a novel framework for understanding amyloid deposition in organs.

How foreign genes become permanent in parasitic plants

Researchers at the University of Osaka developed a catalyst that uses ultrasonic vibration to convert CO2 into CO. By modifying the catalyst with a metal–organic framework (MOF) incorporating isolated copper atoms, the catalyst is designed to concentrate CO2 near copper reaction sites and make better use of piezo-induced charges generated by vibration. It achieved a CO production rate of 114 μmol g-1 h-1, nearly five times that of pristine BaTiO3. The findings provide a new strategy for using mechanical energy to support more efficient carbon recycling.

Researchers at the University of Osaka developed chiral hole-transport materials that selectively conduct electrons according to spin. Across three classes of materials, molecular handedness consistently determined the direction of spin polarization. The homochiral material also showed nearly threefold higher hole mobility and improved charge extraction and surface passivation in perovskite solar cells, highlighting new possibilities for controlling spin, charge transport, and interfaces through molecular design.

Researchers at the University of Osaka and the Osaka Institute of Public Health found that pertussis-associated DNA in wastewater increased weeks before reported cases, with the main analysis showing a 10-week lead. The findings suggest that wastewater monitoring could complement clinical surveillance by detecting changes in community transmission earlier, although further research is needed before it can be used as a validated forecasting tool.

Researchers from the University of Osaka have developed a fast computational framework that predicts the optical performance of quantum color centers without being restricted to a specific host material. By replacing computationally intensive calculations with simple theoretical formulas and procedures, the method enables rapid screening of promising quantum materials spanning ultraviolet to telecommunication wavelengths.

Developmental disorders, including autism, entail challenges in social life; as the number of affected individuals has risen, this has become a significant societal concern. Using a mouse model, we demonstrate that a mutation in CHD8, a gene associated with autism spectrum disorder, causes abnormal differentiation of ventral progenitor cells, leading to autistic-like behavior in adulthood. This should lead to the elucidation of mechanisms underlying autism onset during brain development and to the advancement of therapeutics.

Researchers perform a full Glauber-theory calculation that overcomes long-standing computational challenges

We study the ground state of the spin-1/2 XXZ antiferromagnet on the triangular lattice in the easy-axis regime using density-matrix renormalization group with spiral boundary conditions. The ordered state remains a nontrivial three-sublattice Y-like structure over a wide anisotropy range. Extrapolation shows incomplete sublattice polarization even in the Ising limit. Energy comparisons demonstrate that the Y state is favored over the up-down-down state, stabilized by quantum fluctuations from the degenerate Ising manifold.