09 Jan 2024
Researchers from Osaka University and collaborating partners have, via reductive amination, resolved a problem that has limited the applicability of carboxylic acids to alkylamine production. Their experimental protocol is environmentally sustainable, simple and convenient to conduct, and works for a broad range of starting materials. This work is an important advance in green chemistry that might help minimize the environmental footprint of synthesizing a class of molecule that's used to manufacture many everyday products.
05 Jan 2024
What actually happens is much weirder, and may help us understand more about quantum mechanics
01 Jan 2024
Researchers from Osaka University have shown that a protein called HKDC1 is a new target of another protein, TFEB, and plays key roles in maintaining the stability of both mitochondria and lysosomes. HKDC1 is essential for mitophagy to remove damaged mitochondria, and mediates mitochondria–lysosome contact, which is critical for lysosomal repair. The role of HKDC1 in maintaining the stability of these organelles counteracts cellular senescence, revealing HKDC1 as a potential therapeutic target for age-related diseases.
26 Dec 2023
Researchers from Osaka University and Shenzhen Bay Laboratory found that neuronal activity induces gene expression at sites of acetylation by promoting the emergence of cAMP response element binding protein (CREB), CREB binding protein (CBP), and RNA polymerase II. These proteins are targeted to the appropriate sites by CBP-mediated histone acetylation at activity-dependent gene loci.
25 Dec 2023
Kavli IPMU researchers are part of a team that has shown it is possible to image small animal tissue clearly to several hundred micrometers using multi-probe imaging.
Artistic depiction of extremely reactive molecules called radicals being generated from plastic fibers. (Illustration: Koji Kubota and Hajime Ito)
25 Dec 2023
Researchers employ common plastics to kickstart radical chain reactions, creating a way to reuse plastic waste while improving process safety and efficiency.
Exploring the correlation between restriction on human mobility and the cost of lifestyle-related diseases during the COVID-19 pandemic
22 Dec 2023
Researchers from Osaka Metropolitan University assessed the correlation between human mobility restrictions and the medical costs associated with lifestyle-related diseases during the COVID-19 pandemic in Japan. A cross-sectional study revealed that an increase in walking and public transit use was associated with reduced medical costs of lifestyle diseases. These findings implicate governments to take measures other than restricting walking and public transit during pandemics and emphasize the importance of walkable cities.
22 Dec 2023
Researchers from Osaka University developed a bio-logger for seabirds that enables long-term observation of rare behaviors. The bio-logger employs low-power depth sensors and accelerometers to identify rare behavior using a light-weight outlier detection model and records the behavior in a 5-min video. Observations using the bio-loggers on Streaked Shearwaters revealed novel aspects of head-shaking and foraging strategies. This approach will enable a wider range of animal behaviors in various environments to be observed.
21 Dec 2023
Kavi IPMU researchers have analyzed more than one million galaxies to explore primordial fluctuations that seeded the formation of the structure of the entire universe.
21 Dec 2023
A research group led by Osaka University and University of Hawaii Manoa found that in female fruit flies, microorganisms enhance reproductive function, boosting the number of cells that form eggs and the number of mature eggs. This is done by controlling the release of hormones to speed up cell division in the ovaries, and limiting programmed cell death. These findings could improve reproductive medicine and could aid the development of new methods to enhance fertility.
21 Dec 2023
A team of researchers has developed an innovative method to design complicated all-α proteins, characterized by their non-uniformly arranged α-helices as seen in hemoglobin. Employing their novel approach, the team successfully created five unique all-α protein structures, each distinguished by their complicated arrangements of α-helices. This capability holds immense potential in designing functional proteins.
21 Dec 2023
In a phase 2 trial, researchers from Osaka University have found that erythromycin, a commonly used antibiotic, has acceptable safety and tolerability profiles in patients with myotonic dystrophy type 1. This common form of muscular dystrophy currently has no cure, and the research team is hopeful that phase 2b and 3 trials will further reveal the efficacy of erythromycin as a treatment—at least in some patients.
21 Dec 2023
Researchers from Osaka University have discovered how amino acids activate a key cell, TORC1, which is a master regulator in living organisms that controls whether cells grow or recycle their contents in yeast. Notably, the team found that the amino acid cysteine is sensed by a protein called Pib2 and that the two bind together to trigger TORC1. This is important because faulty TORC1 has been linked to disease such as cancer.
21 Dec 2023
Researchers from Osaka University have shown that the rare D-form of the amino acid alanine shows a clear circadian rhythm, and is able to affect the circadian clock and regulate gluconeogenesis, a method of glucose release, in the kidney. D-alanine upregulates genes linked to both gluconeogenesis and the circadian rhythm through the circadian transcriptional network. D-alanine is linked to many metabolic and immunological diseases, and this mechanistic insight could potentially lead to novel therapeutic approaches.
20 Dec 2023
Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University report in Nature Communications a high-speed atomic force microscopy study of the structural dynamics of sodium ion channels in cell membranes. The findings provide insights into the mechanism behind the generation of cell-membrane action potentials.
Fibroblasts changes their migration speed to the wound site depending on the circadian rhythms of primary cilium length.
20 Dec 2023
We’re all familiar with our body’s internal clock: it gives us cues on when to wake and when to rest, but it also can determine the rate and time of day at which your body most effectively heals wounds.
4.5SH RNA (green) is located in the nuclear speckles (Srsf1, magenta)—structures in the cell nucleus associated with gene expression—in embryonic stem cells, where it plays an essential role in RNA processing. (Rei Yoshimoto, et al. Molecular Cell. December 13, 2023)
13 Dec 2023
A previously mysterious small RNA molecule in mice is found to play a crucial role in gene expression, and may be the first identified member of a new class of regulatory RNAs.
Generating canine induced pluripotent stem cells (iPSCs) without using feeder cells
13 Dec 2023
Scientists at Osaka Metropolitan University have developed an efficient, non-invasive, and pain-free method to generate canine-induced pluripotent stem cells (iPSCs). They identified six reprogramming genes that can boost canine iPSC generation by 120 times compared to conventional methods using fibroblasts. The iPSCs were created from urine-derived cells without the need for feeder cells, an impossible feat until now. Their findings are expected to advance regenerative medicine and genetic disease research in veterinary medicine.
12 Dec 2023
Researchers from Osaka University created an online space for conversation, collaboration and knowledge sharing among patients with rare diseases, their families, researchers and policymakers. A series of workshops generated evidence that could contribute to new policies in the field of rare diseases and explore ways that stakeholders could be involved in the process.
12 Dec 2023
Researchers from Osaka University and collaborating partners have developed a new means of manipulating Mie scattering from nanostructures. By judicious choice of the laser illumination position with respect to the center of a nanostructure, one can strongly enhance optical responses that would not have been otherwise possible. This work is an important milestone in modern meta-photonics and will benefit computing and communication technologies.
08 Dec 2023
Researchers at Kanazawa University report in Frontiers in Molecular Biosciences a computational method to predict the placement of proteins on AFM substrates based on electrostatic interactions.
08 Dec 2023
Researchers from Osaka University investigated the thermal energy changes across nanopores that allow the selective flow of ions. Switching off the flow of ions in one direction led to a cooling effect. The findings have applications in nanofluidic devices and provide insight into the factors governing ion channels in cells. The nanopore material could be tailored to tune the cooling and arrays could be produced to scale up the effect.
07 Dec 2023
A research team led by Osaka Metropolitan University focused on generative AI as an information-gathering tool in the medical field. The results showed that one of the generative AIs suggested mostly fictitious references, while the other suggested multiple references with the same level of accuracy as the researchers. The use of generative AI in literature search suggests the possibility of efficiently collecting a vast amount of medical information, provided that users are well aware that the performance of generative AI is still in its infancy and that not all information presented is necessarily reliable. It is advised to use different generative AIs depending on the type of information needed.
30 Nov 2023
An international team of researchers led by Osaka Metropolitan University has elucidated the process by which the major flavonoids naringenin, apigenin, and genistein are metabolized in the body. These findings are fundamental in elucidating the correlation between the metabolism of flavonoids in the body and their potential health benefits.
Deep-sea hydrothermal vent 'Crab Spa'
30 Nov 2023
A new bacterial species discovered at the deep-sea hydrothermal vent site ‘Crab Spa’ provides a deeper understanding of bacterial evolution.
Due to a high concentration of people and activities in cities, they are at the forefront of battle against climate change.
30 Nov 2023
Aids local governments in adapting to the threats of climate change
29 Nov 2023
Researchers at Kanazawa University report in Science Advances how they can accelerate and decelerate chirality inversion in large cage molecules using alkali metal ion binding.
27 Nov 2023
A research team from Osaka Metropolitan University has successfully developed a novel pneumococcal vaccine by combining the team’s proprietary mucosal vaccine technology with pneumococcal surface proteins that can cover a wide range of serotypes. Experiments were conducted using mice and macaques and it was confirmed that pneumonia caused by pneumococcal infection was clearly suppressed in the target groups of animals inoculated with the vaccine.
27 Nov 2023
Researchers from Osaka University found that HSP47, a collagen-specific chaperone, is a key determinant of body fat levels. HSP47 expression levels are upregulated with obesity and greater food intake and decreased with fasting, exercise, calorie restriction, bariatric surgery, and wasting syndrome, suggesting that HSP47 modulation has a profound effect on fat storage.
22 Nov 2023
Osaka Metropolitan University researchers and their colleagues have successfully detected an ultra-high-energy cosmic ray with an energy level comparable to the most energetic cosmic ray ever observed. The cosmic ray is set to be named after the Japanese sun goddess, Amaterasu. No promising astronomical object has been identified in the direction from which this cosmic ray originated, implying the potential existence of unknown astronomical phenomena and novel physical origins beyond the Standard Model.


27 Aug 2008
Realizing high quality of life and extension of health life expectancy through the consolidation of advanced science, health studies, and medical care
12 Jul 2008
The sessions include "Promise and problems of molecular targeted therapiesin children: Lessons from Hedgehog pathway inhibitors", "Regeneration of the damaged Central Nervous System", "Imaging cognition and genetics" and "Aquaporin water channels: from atomic structure to clinical medicine"
11 Jun 2008
The British Nobel Laureate Lecture Series, a collaboration between Keio University and the British Embassy, commemorates the 150th anniversaries of the founding of Keio University, and the initiation of UK- Japan diplomatic relations. Four lectures will be held as a part of Keio's 150th Anniversary Commemorative Project and UK-JAPAN 2008.
06 Jun 2008
Topics include Latest Trend in Standardization of IPTV, Trend in Standardization of Content Creation and Digital Rights Permission Code, International Standardization of 4th Generation Mobile Communication and Strategy in Japan and more
12 Jun 2008
A collaboration between Keio University and the Dutch Embassy in Japan, this seminar on international peace cooperation will focus on the relationship between security and development in the provision of international assistance to conflict and post-conflict areas.
20 May 2008
Postsocialist economies in Asia as well as in Europe pose many problems for economic policy makers and the international community since the fall of the Iron Curtain. This lecture will provide a broad review of the experience of dealing with postsocialist economies that has been accumulated at the Halle Institute for Economic Research.
29 May 2008
Tokyo, Japan - Special Lecture in English on US-China Relations by Professor Harry Harding, from George Washington University. This programme is sponsored by Graduate School of Asia-Pacific Studies and Waseda University Institute of Asia-Pacific Studies.
09 May 2008
Keio University and the British Embassy in Tokyo present KEIO 15O/ UK-JAPAN 2008 British Nobel Laureate Lecture Series
30 May 2008
KEIO University and the Embassy of Greece to Japan are organising a symposium dedicated to the most translated Greek writer of the 20th century, Νikos KAZANTZAKIS.
12 Apr 2008
Where Is Japan Headed? :Views and Expectations from Overseas
10 Mar 2008
The Tokyo University of Science will be holding the first International Collaboration Workshop in March 2008 with the University of California at Davis, University of California at Santa Cruz and Ohio State University. Another nine world leading research universities are invited. The topics of the workshop is focusing on "Materials Research" f
10 Mar 2008
Tokyo University of Science will hold the 3rd International Symposium on "Promotional Bases for Leading Architectural Fire Safety Engineering Research" at Tokyo, March 10 and 11
11 Mar 2008
The Model G8 Youth Summit 2008 will be held in Yokohama and Tokyo from 11 to 15 March, 2008. Participants will act as government representatives, secretaries, and sherpas to discuss a topic. A panel discussion will also be held in regards with environmental issues. Panelists include leading figures from various fields such as Prof. Heizo Takenaka.
26 Feb 2008
This conference will serve to launch JCOR (the Japanese Centre for Ontological Research), which has recently been funded by the Japanese Government's Ministry of Education and Science (MEXT) under the framework of the Open Research Centre on Logic and Formal Ontology.
20 Dec 2007
New Delhi, India - Author, poet, foreign policy expert, columnist, and Rhodes scholar, former Ambassador Aftab Seth will speak on "Japan Today: A Deflated Giant?'
18 Sep 2007
SOI Asia and Platform Design Laboratory,Keio Research Institute at SFC will hold an online international symposium on Entrepreneur on Tuesday, September 18th, 2007, from 16:00 to 19:00(Japan Time).
18 Sep 2007
Skill Science is a new multidisciplinary research area with approaches including artificial intelligence, cognitive science, sports science, bio-mechanism, ecological psychology and so on. In the future, it is expected to bring insight into researches on robotics, aiming to bring human-like flexible and skillful movement into realization.
03 Sep 2007
The Quantum Group of the Quantum Bio-Informatics Center’s (QBIC) Research Center will host an event entitled the “Mini-Workshop on Recent Experimental Results of Cuprates.” Researchers from differing fields (STM, ARPES, Neutron, NMR, etc.) will be invited to the mini-workshop to explore its topic over the course of two days.
07 Jun 2007
The Research Center for the Holistic Computational Science of the TUS Research Institute for Science and Technology is to hold an international symposium on the theme "Frontiers in Computational Science of Nanoscale Transport" in conjunction with the Atomistix Workshop 2007.
27 Apr 2007
London - World renowned academics from Keio University and University College London will be presenting the latest advances in neuroscience research in this afternoon symposium. Attendance is free of charge.
26 Mar 2007
Tokyo Japan - In celebration of its 150-year anniversary next year, Keio University will organize a two-day workshop for graduate students entitled "Changing Faces of Nationalism in Asia" on 26-27 March 2007.
14 Mar 2007
The International Conference in Quantum Bio-Informatics Center (QBIC) will be held at Noda Campus of Tokyo University of Science from March 14 to March 17, 2007
02 Dec 2005
Theme: Advanced technologies for building sustainable society
14 Jan 2006
This event is Free of charge and will be conducted in English
29 Jun 2005
Health social security in Japan is at a cross-road: whether to gradually reduce the coverage to a basic minimum as in the United States, or to maintain the current level following the European example.


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Giants in history

Ruby Sakae Hirose (1904 – 1960) was a Japanese-American scientist whose research contributed significantly to our understanding of blood clotting, allergies and cancer.
Haisako Koyama (1916 – 1997) was a Japanese solar observer whose dedication to recording sunspots – cooler parts of the sun’s surface that appear dark – produced a sunspot record of historic importance.
Michiaki Takahashi (17 February 1928 – 16 December 2013) was a Japanese virologist who developed the first chickenpox vaccine.
Toshiko Yuasa (11 December 1909 – 1 February 1980) was the first Japanese female physicist whose research on radioactivity shed light on beta decay – the process in which an atom emits a beta particle (electron) and turns into a different element.
Baron Kitasato Shibasaburo (29 January 1856 – 13 June 1931) was a Japanese physician and bacteriologist whose work led to a new understanding of preventing and treating tetanus, diphtheria and anthrax.
By isolating soil microorganisms and studying the compounds they produce, Satoshi Omura (born 1935) discovered almost 500 organic compounds with unique properties that were produced by these microorganisms, including many new antibiotics.
In 1915, pathologist Katsusaburo Yamagiwa and his research assistant Koichi Ichikawa became the first to prove that chronic exposure to chemicals can cause cancer.
In 1915, Koichi Ichikawa along with pathologist Katsusaburo Yamagiwa became the first to prove that chronic exposure to chemicals can cause cancer.
Reiji Okazaki (8 October 1930 – 1 August 1975) and Tsuneko (7 June 1933) were a Japanese couple who discovered Okazaki fragments – short sequences of DNA that are synthesized during DNA replication and linked together to form a continuous strand.
Tsuneko (7 June 1933) and Reiji Okazaki (8 October 1930 – 1 August 1975) were a Japanese couple who discovered Okazaki fragments – short sequences of DNA that are synthesized during DNA replication and linked together to form a continuous strand.
Husband and wife team, Kimishige (3 December 1925 – 6 July 2018) and Teruko Ishizaka (28 September 1926 – 4 June 2019) discovered the antibody class Immunoglobulin E (IgE) that triggers allergic reactions. They also discovered that IgE antibodies attach to white blood cells, known as mast cells, releasing histamine, which causes allergic reactions.
Husband and wife team, Kimishige (3 December 1925 – 6 July 2018) and Teruko Ishizaka (28 September 1926 – 4 June 2019) discovered the antibody class Immunoglobulin E (IgE) that triggers allergic reactions. They also discovered that IgE antibodies attach to white blood cells, known as mast cells, releasing histamine, which causes allergic reactions.
Japanese chemist Takamine Jokichi (3 November 1854 – 22 July 1922) founded the Tokyo Artificial Fertilizer Company, where he isolated a starch-digesting enzyme (named takadiastase) from the fungus Aspergillus oryzae.
Hideki Yukawa (23 January 1907 – 8 September 1981) was awarded the Nobel Prize in Physics in 1949 for predicting the existence of the pi meson subatomic particle. Japan’s first Nobel laureate, Yakawa also expressed his support for nuclear disarmament by signing the Russell–Einstein Manifesto in 1955.
Shinichiro Tomonaga (31 March 1906 – 8 July 1979), together with Richard Feynman and Julian Schwinger, was awarded the Nobel Prize in Physics in 1965, for their contributions to advance the field of quantum electrodynamics. Tomonaga was also a strong proponent of peace, who actively campaigned against the proliferation of nuclear weapons and promoted the peaceful use of nuclear energy.
Japanese chemist Kenichi Fukui (4 October 1918 – 9 January 1998) was the first Asian scientist to be awarded the Nobel Prize in Chemistry. Together with Roald Hoffman, he received this honour in 1981 for his independent research into the mechanisms of chemical reactions.
Minoru Shirota (April 23, 1899 – March 10, 1982) was a Japanese microbiologist who invented the popular fermented drink Yakult.
Japanese physicist Ukichiro Nakaya (1900-1962) made the world’s first artificial snowflakes. He started his research on snow crystals in the early 1930s at Hokkaido University, where there is an unlimited supply of natural snow in winter. By taking over 3,000 photographs, he established a classification of natural snow crystals and described their relationship with weather conditions.
The techniques that make industrial pearl culturing possible were developed over a century ago at the Misaki Marine Biological Station in Japan. The station’s first director, Professor Kakichi Mitsukuri, emphasized to Kokichi Mikimoto in 1890 that stimulating pearl sac formation was important for pearl growth, and they went on to successfully develop methods for culturing pearls.
The field of solid-state ionics originated in Europe, but Takehiko Takahashi of Nagoya University in Japan was the first to coin the term ‘solid ionics’ in 1967. ‘Solid-state ionics’ first appeared in 1971 in another of his papers, and was likely a play on ‘solid-state electronics’, another rapidly growing field at the time.
Chika Kuroda (24 March 1884 – 8 November 1968) was a Japanese chemist whose research focussed on the structures of natural pigments.
Motoo Kimura (13 November 1924 – 13 November 1994) was a Japanese theoretical population geneticist who is best remembered for developing the neutral theory of molecular evolution.
Osamu Shimomura (27 August 1928 – 19 October 2018) was a Japanese organic chemist and marine biologist who dedicated his career to understanding how organisms emitted light.
Kikunae Ikeda (8 October 1864 – 3 May 1936) was a Japanese chemist who discovered the fifth basic taste, umami.
Umetaro Suzuki (7 April 1874 – 20 September 1943) was a Japanese scientist best remembered for his research on beriberi, a disease caused by vitamin B1 deficiency, characterized by limb stiffness, paralysis and pain.
Kono Yasui (16 February 1880 – 24 March 1971) was a Japanese botanist who researched the genetics of poppies, corn and spiderworts and surveyed the plants that had been affected by the nuclear fallout after the atomic bombings of Hiroshima and Nagasaki.
Hitoshi Kihara (1893 – 1986) was one of the most famous Japanese geneticists of the 20th century. One of his most significant contributions was identifying sex chromosomes (X and Y) in flowering plants.
Michiyo Tsujimura (17 September 1888 – 1 June 1969) was a Japanese agricultural scientist and biochemist recognized for her research of green tea components.
A Japanese surgeon, Tetsuzo Akutsu (20 August 1922 – 9 August 2007) built the first artificial heart capable of keeping an animal alive.
Ogino Ginko (3 March 1851 – 23 June 1913) was the first registered female doctor to practise modern medicine in Japan.
Japanese geochemist Katsuko Saruhashi developed the first method and tools for measuring carbon dioxide in seawater