Japan

Evaluation of developmental toxicity in early chicken embryos exposed to tris(2-chloroisopropyl) phosphate

This study examined how the origin (wild or hatchery-reared), feeding area (Baltic Sea mainstem, Bosnian Sea, and Gulf of Finland), and organic halogen compound (OHC) concentrations of Baltic Sea Atlantic salmon (Salmo salar) affect the salmon liver proteome, transcriptome, and oxidative stress markers. Results suggest that the Baltic salmon liver proteome, together with the transcriptome, is influenced more by OHC concentrations and oxidative stress levels in the feeding area than by their origin.

Structural characteristics of environmental pollutants and computer simulations predict effects on the endocrine system of seals

A broad-spectrum antiviral drug candidate, 2-thiouridine, that targets positive-strand RNA viruses has been identified and characterized.

A research team from Osaka Metropolitan University has found that polysulfides are abundant in broccoli sprouts. They found that the amount of polysulfides increased dramatically during growth, by an approximately 20-fold in seeds by the fifth day of germination. Furthermore, a comprehensive analysis of the polysulfides detected a number of polysulfide candidates whose structures have not yet been determined. The identification of these unknown polysulfides and detailed analysis of their pharmacological activities are expected to enable the development of new preventive and therapeutic strategies and medicines for cancer, neurodegenerative diseases, stroke, inflammation, and other diseases.

Risk-averse on/off-target assessment for CRISPR editing without reference genome

The latest ‘large language model’ artificial intelligence system, GPT-4, could aid chemistry researchers, but limitations reveal the need for improvements.

Researchers from Osaka University developed a cell-friendly means of bioprinting at high fidelity. By successive injection of a cell-based ink and a printing support, the ink solidified into defined geometries, even into the shape of a human nose. Printed cells remained viable for at least two weeks. This work is an important milestone toward developing lab-grown tissues and organs, and eventually advancing regenerative medicine as well as animal-free drug safety testing.

A new amphipod species thrives at record temperatures in nearby hot spring pools of an ancient Inca city, defying norms for these typically cold-dwelling animals. Unraveling its key adaptations can give clues for the survival of other freshwater creatures in our warming world.

Osaka Metropolitan University scientists, in cooperation with researchers from the National Astronomical Observatory of Japan, have captured cosmic-ray extensive air showers with unprecedented precision using the prime-focus wide field camera mounted on the Subaru Telescope, situated atop Mauna Kea in Hawaii. Analyzing approximately 17,000 images captured between 2014 and 2020, they pinpointed 13 images containing extensive air showers, with a number of particle tracks far exceeding the usual count.

Researchers from Osaka University developed wirelessly powered soil moisture sensing technology that will help meet the needs of sustainable precision agriculture. Both the soil moisture content and the position of each sensor are readily detected and transmitted, even at high sensor densities. The sensors are largely biodegradable and can be tilled into the soil at the end of the crop season. This work might help farmers allocate resources to cropland in a timely, targeted manner.

Researchers from the Institute of Industrial Science, The University of Tokyo, synthesize a two-center zinc complex that absorbs visible light as a solid and in solution.

A research team led by Osaka University developed a theranostics approach to both diagnose and treat certain pancreatic cancer cases. They radioactively labeled a monoclonal antibody targeting glypican-1, which is highly expressed in pancreatic cancer, then administered it to disease model mice. One label, 89Zr, showed high uptake in tumors, which would allow early detection of pancreatic cancer with PET scans. Another label, 211At, was used with alpha therapy to significantly slow tumor growth.

Researchers at Osaka University developed a nanostructured light diffuser that provides balanced lighting by diffracting blue and red light, and can be cleaned by simple rinsing with water. The diffuser consists of cheap materials and can be shaped with common tools. A protective glass coating maintains the diffuser’s optical performance yet adds durability. This work might improve the visual performance of everyday lighting displays.

The International Symposium on Triglyceride/Neutral Lipid and Rare Diseases will be held at the Kyoto International Conference Center on October 21 and 22, 2023. The symposium is organized by the International Symposium on Triglyceride/Neutral Lipid and Rare Diseases Conference Committee, which is led by Dr. Ken-ichi Hirano (Graduate School of Medicine, Osaka University) and the Japan Intractable Diseases (Nanbyo) Research Foundation.

To extend the depth of field in mask-based lensless cameras, researchers from Osaka University replaced conventionally coded masks with a radial-coded mask optimized to balance the frequency response. As a result, the point spread function depends less on distance, and subjects at various depths can be clearly imaged. Experiments in simulation and on a prototype show that the depth of field of the camera is extended when the proposed radial mask is used.

Acoels have been found to host a wide diversity of symbiotic, photosynthetic microalgae.

Osaka Metropolitan University researchers have used the power of laser light to accelerate the reaction between cancer cell-derived extracellular vesicles—a kind of nanoparticle—and antibody-modified microparticles. The three-dimensional structure of the resulting aggregates was then analyzed using a confocal optical system. The results demonstrated the ability to measure, within 5 minutes, approximately 1,000 to 10,000 nanoscale EVs contained in a 500 nL sample.

Researchers from Osaka University have developed a data-driven AI algorithm for controlling the heating and cooling of an office building. The system does not require ambient sensors or specific knowledge of the building’s rooms. During heating operations, the system was able to achieve energy savings of up to 30%, which can represent significant reductions to cost and environmental impact.

The researchers from Osaka University showed how two psychological factors, belief in just deserts (BJD) and human rights restrictions (HRR), differ across countries. BJD tended to be higher in Japan and lower in the UK, whereas HRR was higher in China and lower in Japan. Public health messages for high-HRR individuals could potentially be used effectively to reduce disease-related discrimination and prejudice.

Observations during two flybys by the Mio spacecraft as part of the BepiColombo International Mercury Exploration Project have revealed that chorus waves occur quite locally in the dawn sector of Mercury. Mercury's magnetic field is about 1% of that of Earth, and it was unclear whether chorus waves would be generated like on Earth. The present study reveals that the chorus waves are the driving source of Mercury’s X-ray auroras, whose mechanism was not understood.

The authors discovered a shorter isoform of Rubicon called RUBCN100, which enhances autophagy in B cells.

The authors identified a structure in the circadian mRNA Period2 that affects the sleep-wake cycle. The results indicate how translation and post-transcriptional processes influence the body’s internal clock and its impact on sleep patterns.

Researchers at Osaka Metropolitan University have succeeded in printing uniformly sized droplets with a diameter of approximately 100 µm using a liquid film of fluorescent ink. This ink, with a viscosity roughly 100 times that of water, was irradiated with an optical vortex, resulting in prints of exceptional positional accuracy at the micrometer scale.

Concave, umbrella-like metal complexes provide space to enable the largest molecular rotor operational in the solid-state.

A recent discovery in spintronics could potentially transform future electronics. A group of researchers have revealed the key role of cobalt-tin-sulfur in reducing energy consumption, unlocking new possibilities for high-speed, low-power spintronic devices.

A team led by researchers at SANKEN (The Institute of Scientific and Industrial Research), at Osaka University has used neutron crystallography to image all of the atoms in a radical intermediate of a copper amine oxidase enzyme. They disclosed previously unknown details, such as precise conformational changes, that help to explain the enzyme's biochemistry. This work might help researchers engineer enzymes that facilitate unusual chemistry or are highly efficient at room temperature that are useful in chemical industry.

Researchers led by Osaka University developed a novel genome editing technique known as NICER, which results in significantly fewer off-target mutations than CRISPR/Cas9 editing. The technique uses a different type of enzyme that makes single-stranded “nicks” in the DNA. Repair of these nicks is more efficient and accurate than repair of double-strand breaks caused by the current CRISPR/Cas9 editing. This technique represents a novel approach for the treatment of genetic diseases caused by heterozygous mutations.

A reanalysis of studies on night shift naps reveals the ideal snoozing schedule that may help combat fatigue and drowsiness when staying up all night.

Lab-based studies reveal how carbon atoms diffuse on the surface of interstellar ice grains to form complex organic compounds, crucial to reveal the chemical complexity in the universe.