Japan

The authors identified a structure in the circadian mRNA Period2 that affects the sleep-wake cycle. The results indicate how translation and post-transcriptional processes influence the body’s internal clock and its impact on sleep patterns.

Researchers at Osaka Metropolitan University have succeeded in printing uniformly sized droplets with a diameter of approximately 100 µm using a liquid film of fluorescent ink. This ink, with a viscosity roughly 100 times that of water, was irradiated with an optical vortex, resulting in prints of exceptional positional accuracy at the micrometer scale.

Concave, umbrella-like metal complexes provide space to enable the largest molecular rotor operational in the solid-state.

A recent discovery in spintronics could potentially transform future electronics. A group of researchers have revealed the key role of cobalt-tin-sulfur in reducing energy consumption, unlocking new possibilities for high-speed, low-power spintronic devices.

A team led by researchers at SANKEN (The Institute of Scientific and Industrial Research), at Osaka University has used neutron crystallography to image all of the atoms in a radical intermediate of a copper amine oxidase enzyme. They disclosed previously unknown details, such as precise conformational changes, that help to explain the enzyme's biochemistry. This work might help researchers engineer enzymes that facilitate unusual chemistry or are highly efficient at room temperature that are useful in chemical industry.

Researchers led by Osaka University developed a novel genome editing technique known as NICER, which results in significantly fewer off-target mutations than CRISPR/Cas9 editing. The technique uses a different type of enzyme that makes single-stranded “nicks” in the DNA. Repair of these nicks is more efficient and accurate than repair of double-strand breaks caused by the current CRISPR/Cas9 editing. This technique represents a novel approach for the treatment of genetic diseases caused by heterozygous mutations.

A reanalysis of studies on night shift naps reveals the ideal snoozing schedule that may help combat fatigue and drowsiness when staying up all night.

Lab-based studies reveal how carbon atoms diffuse on the surface of interstellar ice grains to form complex organic compounds, crucial to reveal the chemical complexity in the universe.

Scientists have found that extracellular calcium mediates the activation of a membrane protein that waves the flag signalling cell death

To address the lack of suitable training data for deep-learning semantic segmentation models in urban landscaping, researchers from Osaka University developed a method that generates a training dataset without the need for real images or a model of an existing city. The method, which is based on procedural modelling and image-to-image techniques, enables segmentation models to achieve comparable performance under some conditions at a fraction of the cost of real dataset generation.

Systematic copper doping boosts all-solar utilization in tungstic acid nanocrystals.

An international team of scientists has successfully conducted large-scale helicopter-based observations along the coast of East Antarctica and has identified pathways through which warm ocean water flows from the open ocean into ice shelf cavities for the first time.

Patients with a specific form of chronic indigestion react differently to images of food, compared to healthy control subjects or patients with irritable bowel syndrome.

A research team led by researchers from Osaka University created an aluminum-nitride device that can convert visible light into deep-ultraviolet light through the process of second harmonic generation. This work can lead to the development of practical devices that can sterilize surfaces with ultraviolet radiation while using less energy.

Elusive fundamental particles called neutrinos are predicted to interact unexpectedly with photons under extreme conditions.

Researchers at Osaka Metropolitan University have developed a measurement technique that rapidly measures the number of viable bacteria in food products. They have succeeded in drastically reducing the inspection time from 2 days to about 1 hour. With this technology, it will be possible to confirm food safety before shipment from factories and prevent food poisoning.

AXL and EGFR inhibitors combined hold promise in fighting certain head, neck, and lung cancers

Researchers from Osaka University have revealed that the expression of a specific isoform of GREB1 Is4 is induced in malignant melanoma cells by the melanocyte-specific transcription factor, MITF. They revealed that GREB1 Is4 stimulates pyrimidine biosynthesis and promotes cancer cell proliferation. Furthermore, the anti-tumor effect of antisense nucleic acids against GREB1 showed a potential new modality for malignant melanoma.

In recent years, an emerging zoonotic pathogen called E. albertii, transmitted by wild animals such as raccoons, has garnered attention due to its remarkable similarities to several strains of Escherichia coli (E. coli), including O157, and its potential to cause severe illness, particularly in children. A research group at Osaka Metropolitan University has developed a novel culture medium that allows for the selective cultivation of E. albertii from raccoon fecal samples. This enabled the successful isolation of E. albertii even from samples with very low quantities of this bacterium. Their findings are expected to further elucidate the bacteriological characteristics of E. albertii and to contribute to the control of foodborne illnesses.

Researchers at Kanazawa University report in Cell Reports how alterations in the nuclear pores lead to the degradation of anti-tumor proteins.

Survey observations with the Subaru Telescope have led to the discovery of 22 quasars in the very distant universe. Their space density indicates the rapid emergence of supermassive black holes soon after the Big Bang, providing strong constraints on models of when, where, and how they formed and grew in cosmic space-time. The results also indicate a small quasar contribution to cosmic reionization, a major phase transition of the early universe.

Machine learning model provides quick method for determining the composition of solid chemical mixtures using only photographs of the sample.

A long-lived monocarpic species of bamboo, Phyllostachys nigra var. henonis, only flowers once every 120 years before it dies. The upcoming flowering event for this species does not bode well for its continued long-term survival, as most flowers are not producing viable seeds.

Osaka Metropolitan University scientists have verified the anticancer effects of Kencur, a tropical plant of the ginger family, mainly grown in Southeast Asia, in cell and animal experiments. They found that Kencur extract and its main active components significantly inhibit cancer cell growth at the cellular and animal levels. Furthermore, the involvement of TFAM in the mechanism of action was confirmed.

The search for innovative materials will be greatly assisted by software that can suggest new experimental possibilities and also control the robotic systems that check them out.

Quantum physicists have found that the outcomes of measurements are shaped by the complex dynamics of measurement interactions, questioning our usual understanding of observable reality.

Osaka Metropolitan University researchers conducted a 5-year claims-based study of 655 non-frail or pre-frail older adults who were certified as having low care needs to investigate the relationship between the risk of frailty and two types of care services. The results showed that users of community-based adult care services had a 40% reduced risk of developing frailty compared to non-users. This suggests that utilizing appropriate support and services can prevent the progression of frailty.

Researchers from SANKEN (The Institute of Scientific and Industrial Research) at Osaka University and two other universities used topological data analysis to improve the predictions of physical properties of amorphous materials by machine-learning algorithms. This may allow for cheaper and faster calculations of material properties.

Anti-estrogenic therapies can suppress the growth of cancer that does not express estrogen receptors; when combined with immune checkpoint inhibitor therapies, they halt tumor progression in mice models.

Researchers at Kanazawa University report in STAR Protocols procedural details and tips for nanoendoscopy-AFM, for capturing images of nanoscale structures inside living cells.