Japan

Researchers at The University of Tokyo simulated fractures in amorphous materials due to both cyclic fatigue and constant stress using course-grained dynamics, and demonstrated various failure modes, which can help improve reliability of materials

Osaka Metropolitan University scientists have successfully developed a new positive electrode material Na2FeS2, consisting of sodium, iron, and sulfur. During testing, batteries using the Na2FeS2 positive electrode had a high energy storage capacity and could be charged and discharged for more than 300 cycles. Because the Na2FeS2 is made of abundant inexpensive elements, it is expected to be used in all-solid-state sodium batteries with higher capacity and lower costs.

Researchers from Hokkaido University and Toppan have developed a method to detect build-up of amyloid β in the brain, a characteristic of Alzheimer’s disease, from biomarkers in blood samples.

Researchers from Osaka University have found that serum albumin interferes with β2m amyloid fibril formation through macromolecular crowding. Monitoring serum albumin concentrations could therefore help prevent patients from developing dialysis-related amyloidosis, a serious complication of long-term dialysis.

Low concentrations of cetylpyridinium chloride, an antimicrobial agent present in mouthwashes, inhibit the infectivity of four variants of SARS-CoV-2.

Researchers from Osaka University and collaborating partners enhanced DNA detection in silicon nitride nanopores by means of a water–glycerol viscosity gradient. Use of common chemistry under electrochemical flow enabled straightforward detection of individual DNA molecules. With further development, the results of this work could dramatically speed up and lower the cost of genomic sequencing, and facilitate unprecedented integration with compact electronics.

Metastasis—when cancer spreads to form new tumors—causes approximately 90% of cancer-related deaths. Because metastatic cancer cells circulate in the blood, the liver—which filters the blood—is considered the most vulnerable organ, so treatments that prevent liver metastasis are urgently needed. A team of Osaka Metropolitan University researchers discovered a mechanism that allows metastatic cancer cells to infiltrate the liver, and how that infiltration can be blocked by inhibiting a related protein.

Osaka Metropolitan University scientists have successfully synthesized 3-hydroxybutyrate, a raw material for poly-3-hydroxybutyrate (PHB)—a strong, water-insoluble, biodegradable plastic used for packaging materials—from acetone and CO2. With a visible light-driven catalytic system utilizing sunlight and two biocatalysts, the researchers achieved a high conversion yield of about 80%. Mimicking natural photosynthesis, this study artificially reproduced a light reaction involving sunlight and a dark reaction fixing CO2 to synthesize the raw material for PHB. The finding is expected to contribute to solving the plastic waste problem and to reducing CO2.

Researchers from Osaka University revealed that the surface electronic structure of topological insulators varies according to its surface atomic structure, even though it was believed to have been protected by the symmetry of the electronic structure inside the crystal and is therefore unaffected by differences in surface atomic structure. This work offers a new means of minimizing the power consumption and increasing the speed of next-generation technology.

A simple and economical method of detecting SARS-CoV-2 viral loads in wastewater with high sensitivity has been developed, expanding the use of wastewater-based epidemiology for tracking the virus in populations.

Research performed on human blastoids, a research model of an early embryo built out of stem cells, may allow scientists to understand better what causes birth defects and lost pregnancies, and so prevent them. But such research is also ethically fraught, warn bioethicists, due to differing beliefs on whether the blastoid possesses sentience or has the potential to do so.

Researchers analyzed how the specific components of peace and environmental sustainability — concepts known to be intrinsically related but often investigated separately — influence each other to better inform policy and decision-making.

Osaka University researchers showed how to use laser beam interference to construct chiral structures. By using computer simulations, they were able to predict the final light pattern and optical radiation force distribution of any collection of light sources. This work may lead to cheaper optical devices and sensors.

Hokkaido University researchers find a new way of producing the industrially important propylene that is more energy efficient than existing approaches—and in the process turns carbon dioxide into another usable resource. Their pioneering catalyst design thus contributes to the carbon neutralization of the petrochemical industry.

A team of researchers have analyzed the elemental composition of asteroid Ryugu using an artificially generated muon beam from a particle accelerator.

Chaos theory improves understanding of Arctic narwhal behavior, with the aim of helping efforts to protect this vulnerable species.

Researchers led by Osaka University developed a novel fluorescent sensor to detect and monitor levels of the neuropeptide oxytocin, also known as the “happy hormone.” The OT sensor facilitated the successful measurement of OT dynamics in the brains of living animals and may serve as a foundation for the development of therapeutics for the treatment of neurological disorders such as autism and schizophrenia.

Researchers at The University of Tokyo grow a nanoscale layer of a superconducting material on top of a nitride-semiconductor substrate, which may help facilitate the integration of quantum qubits with existing microelectronics

Researchers from The Institute of Industrial Science, The University of Tokyo have developed a streamlined photo-uncaging system for photodynamic cancer therapy, using a pulse of light for tumor-specific activation of a cancer-fighting agent

A research group led by the Institute of Industrial Science, The University of Tokyo, finds that sensory neurons in human skin modulate melanocytes via the secretion of Repulsive Guidance Molecule B

The activity of deep-focus earthquakes, which increases with depths from ~400 km to a peak at ~600 km, is enigmatic because conventional brittle failure is unlikely to occur at elevated pressures. Our experiments showed that formation of thin weak layers filled with nano-crystalline olivine/wadsleyite, upon the pressure-induced phase transition of olivine, is the major cause of deep-focus earthquakes on the metastable olivine wedge in deep slabs.

Researchers found a new way to reduce carbon dioxide (CO2) emissions by wrapping copper nanocubes with an organic layer, solving instability and selectivity problems with copper nanocubes in catalysis, and improving how this electrocatalyst converts CO2 into organic molecules.

Osaka University researchers identified the specific protein complex that recognizes when cellular organelles called lysosomes become damaged. When this occurs, the CUL4A protein complex transfers a molecular tag, called polyubiquitin, to a lysosomal protein known as LAMP2. WDFY1, another protein in the complex, is able to recognize and interact with LAMP2. These initial steps are critical to beginning a process called lysophagy, in which these damaged lysosomes are cleared away by the cell.

Scientists from The University of Tokyo formulated nonlinear, nonequilibrium energy dissipation relationships using methods from geometry to better understand the kinetics of irreversible chemical processes

Researchers develop a new integrated framework that factors in the many variables relevant to accurate carbon emissions modeling in the transportation sector, allowing for policymakers to choose the best path to achieve carbon neutrality.

It is commonly believed that patients with chronic kidney disease should limit their protein intake given that excessive protein worsens kidney function. However, a new study by Osaka Metropolitan University scientists indicates that changes in skeletal muscle mass are positively correlated with protein intake, suggesting the necessity of adequate protein intake to improve muscle mass after kidney transplantation.

A team of researchers including Kavli IPMU has found people in Japan, US, and Germany show different concerns regarding Artificial Intelligence (AI) being used in entertainment, shopping services, or to help find criminals.

Demonstration of embodied cognition mechanisms in the brain could have implications for artificial intelligence.

An estimated 1208 excess suicide deaths for men and 1825 for women were recorded during the COVID-19 Pandemic in Japan through December 2021, with the impact being greatest in women and younger age groups.

Research shows that natural catastrophes may trigger or exacerbate attacks of incapacitating migraine in disaster victims.