Japan

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31 May 2023
Osaka Metropolitan University scientists investigated numerically the interaction between a quantized vortex and a normal-fluid. Based on the experimental results, researchers decided the most consistent of several theoretical models. They found that a model that accounts for changes in the normal-fluid and incorporates more theoretically accurate mutual friction is the most compatible with the experimental results.
29 May 2023
Researchers from Osaka University show how their multilegged walking robot can be steered by inducing a dynamic instability. By making the couplings between segments more flexible, the robot changes from walking straight to moving in a curved path. This work can lead to more energy-efficient and reliable robotic navigation of terrain.
26 May 2023
A research team, led by researchers from Osaka University, performed genetic screening of fission yeast lacking DNA repair gene Rad51 to identify genes that play a role in gross chromosomal rearrangement (GCR), a type of mutation that occurs at the centromere. Cells lacking Srr1 or Skb1 exhibited reduced GCR, indicating that these genes are important to the occurrence of GCR. These findings advance our understanding of the mechanisms underlying centromeric GCR.
Context dependence in intercultural communication
26 May 2023
Osaka Metropolitan University scientists found that Japanese and Chinese, who are considered to have high-context cultures with a high degree of reliance on information shared by the speaker and listener, are code-switching from high-context cultures to low-context cultures when communicating with people from each other’s country. Furthermore, the scientists found that the Japanese do not engage in much code-switching with Chinese students in Japan.
Influence of Bacillus subtilis var. natto intake
25 May 2023
Eating fermented foods might be the secret to a healthy and long-lived society
23 May 2023
Two key challenges in chemistry innovation are solved simultaneously by exploring chemical opportunities with artificial intelligence.
Qaanaaq Glacier, Greenland (Photo: Evgeny Podolskiy).
23 May 2023
Acoustic signals can be effectively used for monitoring glacial runoff and provide a cheaper and more accessible alternative to existing methods.
23 May 2023
Researchers from the Institute of Industrial Science, The University of Tokyo, discover how certain colloids can form a solid-like gel and reveal how the mechanism differs from glasses.
19 May 2023
Researchers at the Institute of Industrial Science, The University of Tokyo, use artificial intelligence to help interpret data generated by material science spectroscopy experiments, which can aid in the development of new drugs and organic conductors.
17 May 2023
A research group led by Osaka University has found that plant cells may be able to detect mechanical forces to determine their own position within the leaf—whether they are on the surface or in the inner tissues—and therefore differentiate into appropriate cell types after damage. These findings reveal how plants regenerate the correct type of tissues when damaged, and may improve our understanding of the mechanisms underlying the high regeneration potential of plants.
Targeted knockout offspring produced from OVM-targeted presumptive male germline chimeras
16 May 2023
Researchers have created a genetically edited allergen-free chicken egg that may be safe for those with egg white allergies.
16 May 2023
Researchers at Osaka University discovered a new class of photo-responsive crystal compounds, heteroaromatic 1,2-diketones. Certain light irradiation causes the crystals in these materials to melt, dramatically changing the materials’ properties. One member of this class, SO, shows luminescent changes while melting, which enabled the research team to visualize the crystal-melting process at the molecular level. These findings provide fundamental insights into the mechanisms behind crystal melting and will enable future designs of light-responsive materials.
15 May 2023
Researchers at Kanazawa University report in Nano Letters how high-speed atomic force microscopy leads to insights into processes relevant to Alzheimer’s disease. Moreover, the technique is shown to be an excellent tool for studying the effect of drugs against the disease.
15 May 2023
Researchers at Kanazawa University report in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) high-speed atomic force microscopy experiments that show how ligands associated with stimulating and suppressing activation of the TRPV1 protein increase and decrease the molecule’s structural variations. The observations provide insights into how these heat- and chilli-sensing proteins function.
12 May 2023
Specially coated surfaces help scientists investigate what happens when cell clusters are turned upside down.
Arbuscular mycorrhizal (AM) fungi in the Glomeromycotina colonize plant roots (left, micrograph) and deliver water and nutrients from soil (right). (Tatsuhiro Ezawa).
11 May 2023
A new group of mitochondrial viruses confined to the arbuscular mycorrhizal fungi Glomeromycotina may represent an ancestral lineage of mitoviruses.
oscillon
11 May 2023
Kavli IPMU researchers have discovered a new generic production mechanism of gravitational waves generated by a phenomenon known as oscillons.
11 May 2023
Researchers from Osaka University identified a new protein, NICOL, and described its crucial role in the maturation of sperm, which itself is necessary for male fertility. Mice who lacked this protein were sterile. Such a discovery may have implications for the development of male contraceptives.
Damage to the liver induced by acetaminophen (dotted blue outlines) is almost completely mitigated by CoQ10-MITO-Porter (right), compared to the effect of phosphate buffered saline (left) and direct administration of CoQ10(center). (Mitsue Hibino, et al. Scientific Reports. May 10, 2023).
10 May 2023
A new drug delivery system delivers an antioxidant directly to mitochondria in the liver, mitigating the effects of oxidative stress.
10 May 2023
Adapting a detector developed for space X-ray observation, a team including Kavli IPMU researchers have successfully verify strong-field quantum electrodynamics with exotic atoms.
09 May 2023
Osaka Metropolitan University scientists elucidated the molecular structure of anionic Pt(0) complexes for the first time in collaboration with co-researchers at Paul Sabatier University - Toulouse III. The key to success is the stabilization of anionic Pt(0) complexes (which are usually unstable owing to their electron-donating nature) by the electron-accepting properties of boron compounds. The results of this research allow us to elucidate the properties and functions of highly active chemical species and provide new guidelines for their creation. The research is expected to lead to the development of innovative catalytic reactions mediated by these chemical species.
08 May 2023
Osaka Metropolitan University scientists investigated the prevalence of antimicrobial resistant bacteria in 678 bacterial isolates from 428 companion dogs and 74 companion cats at the Veterinary Medical Center, Osaka Metropolitan University. Two E. coli strains have both a mobile colistin-resistant mcr gene and a third-generation cephalosporin-resistant blaCTX gene. One of these strains, which is found in a dog, was resistant to both colistin and third-generation cephalosporins.
fig1
02 May 2023
Atacama Cosmology Telescope (ACT) collaboration researchers including the Kavli IPMU's Toshiya Namikawa have created a new map of dark matter in the universe confirming Einstein's theory of general relativity.
Revolutionary nanovalve enables active control of single-molecule flows
01 May 2023
A joint research group at Osaka Metropolitan University has succeeded in regulating the flow of single molecules in solution by opening and closing the nanovalve mounted on the nanofluidic device by applying external pressure. The research group fabricated a device with a ribbon-like, thin, soft glass sheet on the top, and at the bottom a hard glass substrate having nanochannels and nanovalve seats. By applying external pressure to the soft glass sheet to open and close the valve, they succeeded in directly manipulating and controlling the flow of individual molecules in solution. They also observed an effect of fluorescence signal amplification when single fluorescent molecules are confined in the tiny nanospace inside the valve. The effect can be ascribed to the nanoconfinement, which suppresses the random motion of the molecules.
Brain under air pollution
28 Apr 2023
Polycyclic aromatic hydrocarbons, in particular, lower the prognosis of ischemic strokes by causing inflammation in the brain.
  Should a "Brain Organoid" be treated as a person by law?
28 Apr 2023
Researchers discuss whether a "brain organoid" should be treated as a person by law, and suggest the need for legal and social discussions uncoupled from debates on consciousness.
27 Apr 2023
Allowing the direct observation of biomolecules in dynamic action, high-speed AFM has opened a new avenue to dynamic structural biology. An enormous amount of successful applications within the last 15 years provide unique insights into essential biological processes at the nanoscale – visualizing, for example, how molecular motors execute their specific functions.
27 Apr 2023
To discover and preserve conservation laws in the data of physical phenomena, researchers from Osaka University developed FINDE, which uses a neural network to represent the underlying conservation laws of a system as opposed to its superficial dynamics. Experiments demonstrated that energy and mass conservation laws, spatial symmetries, and constraints were discovered and preserved, indicating the potential of FINDE to contribute to the development of computer-aided engineering and physics simulations.
26 Apr 2023
Researchers at the Institute of Industrial Science, The University of Tokyo, have developed a desktop charger with voltages high enough to replenish the electric charge on N95 and surgical masks, which is required for effective use
26 Apr 2023
An Osaka Metropolitan University scientist published a review article on numerous asymmetric reactions using arynes, organized by style, and detailed their outline and characteristics. Unresolved issues and prospects in this field were also described.

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Giants in history

Ruby Sakae Hirose (1904 – 1960) was a Japanese-American scientist whose research contributed significantly to our understanding of blood clotting, allergies and cancer.
Haisako Koyama (1916 – 1997) was a Japanese solar observer whose dedication to recording sunspots – cooler parts of the sun’s surface that appear dark – produced a sunspot record of historic importance.
Michiaki Takahashi (17 February 1928 – 16 December 2013) was a Japanese virologist who developed the first chickenpox vaccine.
Toshiko Yuasa (11 December 1909 – 1 February 1980) was the first Japanese female physicist whose research on radioactivity shed light on beta decay – the process in which an atom emits a beta particle (electron) and turns into a different element.
Baron Kitasato Shibasaburo (29 January 1856 – 13 June 1931) was a Japanese physician and bacteriologist whose work led to a new understanding of preventing and treating tetanus, diphtheria and anthrax.
By isolating soil microorganisms and studying the compounds they produce, Satoshi Omura (born 1935) discovered almost 500 organic compounds with unique properties that were produced by these microorganisms, including many new antibiotics.
In 1915, pathologist Katsusaburo Yamagiwa and his research assistant Koichi Ichikawa became the first to prove that chronic exposure to chemicals can cause cancer.
In 1915, Koichi Ichikawa along with pathologist Katsusaburo Yamagiwa became the first to prove that chronic exposure to chemicals can cause cancer.
Reiji Okazaki (8 October 1930 – 1 August 1975) and Tsuneko (7 June 1933) were a Japanese couple who discovered Okazaki fragments – short sequences of DNA that are synthesized during DNA replication and linked together to form a continuous strand.
Tsuneko (7 June 1933) and Reiji Okazaki (8 October 1930 – 1 August 1975) were a Japanese couple who discovered Okazaki fragments – short sequences of DNA that are synthesized during DNA replication and linked together to form a continuous strand.
Husband and wife team, Kimishige (3 December 1925 – 6 July 2018) and Teruko Ishizaka (28 September 1926 – 4 June 2019) discovered the antibody class Immunoglobulin E (IgE) that triggers allergic reactions. They also discovered that IgE antibodies attach to white blood cells, known as mast cells, releasing histamine, which causes allergic reactions.
Husband and wife team, Kimishige (3 December 1925 – 6 July 2018) and Teruko Ishizaka (28 September 1926 – 4 June 2019) discovered the antibody class Immunoglobulin E (IgE) that triggers allergic reactions. They also discovered that IgE antibodies attach to white blood cells, known as mast cells, releasing histamine, which causes allergic reactions.
Japanese chemist Takamine Jokichi (3 November 1854 – 22 July 1922) founded the Tokyo Artificial Fertilizer Company, where he isolated a starch-digesting enzyme (named takadiastase) from the fungus Aspergillus oryzae.
Hideki Yukawa (23 January 1907 – 8 September 1981) was awarded the Nobel Prize in Physics in 1949 for predicting the existence of the pi meson subatomic particle. Japan’s first Nobel laureate, Yakawa also expressed his support for nuclear disarmament by signing the Russell–Einstein Manifesto in 1955.
Shinichiro Tomonaga (31 March 1906 – 8 July 1979), together with Richard Feynman and Julian Schwinger, was awarded the Nobel Prize in Physics in 1965, for their contributions to advance the field of quantum electrodynamics. Tomonaga was also a strong proponent of peace, who actively campaigned against the proliferation of nuclear weapons and promoted the peaceful use of nuclear energy.
Japanese chemist Kenichi Fukui (4 October 1918 – 9 January 1998) was the first Asian scientist to be awarded the Nobel Prize in Chemistry. Together with Roald Hoffman, he received this honour in 1981 for his independent research into the mechanisms of chemical reactions.
Minoru Shirota (April 23, 1899 – March 10, 1982) was a Japanese microbiologist who invented the popular fermented drink Yakult.
Japanese physicist Ukichiro Nakaya (1900-1962) made the world’s first artificial snowflakes. He started his research on snow crystals in the early 1930s at Hokkaido University, where there is an unlimited supply of natural snow in winter. By taking over 3,000 photographs, he established a classification of natural snow crystals and described their relationship with weather conditions.
The techniques that make industrial pearl culturing possible were developed over a century ago at the Misaki Marine Biological Station in Japan. The station’s first director, Professor Kakichi Mitsukuri, emphasized to Kokichi Mikimoto in 1890 that stimulating pearl sac formation was important for pearl growth, and they went on to successfully develop methods for culturing pearls.
The field of solid-state ionics originated in Europe, but Takehiko Takahashi of Nagoya University in Japan was the first to coin the term ‘solid ionics’ in 1967. ‘Solid-state ionics’ first appeared in 1971 in another of his papers, and was likely a play on ‘solid-state electronics’, another rapidly growing field at the time.
Chika Kuroda (24 March 1884 – 8 November 1968) was a Japanese chemist whose research focussed on the structures of natural pigments.
Motoo Kimura (13 November 1924 – 13 November 1994) was a Japanese theoretical population geneticist who is best remembered for developing the neutral theory of molecular evolution.
Osamu Shimomura (27 August 1928 – 19 October 2018) was a Japanese organic chemist and marine biologist who dedicated his career to understanding how organisms emitted light.
Kikunae Ikeda (8 October 1864 – 3 May 1936) was a Japanese chemist who discovered the fifth basic taste, umami.
Umetaro Suzuki (7 April 1874 – 20 September 1943) was a Japanese scientist best remembered for his research on beriberi, a disease caused by vitamin B1 deficiency, characterized by limb stiffness, paralysis and pain.
Kono Yasui (16 February 1880 – 24 March 1971) was a Japanese botanist who researched the genetics of poppies, corn and spiderworts and surveyed the plants that had been affected by the nuclear fallout after the atomic bombings of Hiroshima and Nagasaki.
Hitoshi Kihara (1893 – 1986) was one of the most famous Japanese geneticists of the 20th century. One of his most significant contributions was identifying sex chromosomes (X and Y) in flowering plants.
Michiyo Tsujimura (17 September 1888 – 1 June 1969) was a Japanese agricultural scientist and biochemist recognized for her research of green tea components.
A Japanese surgeon, Tetsuzo Akutsu (20 August 1922 – 9 August 2007) built the first artificial heart capable of keeping an animal alive.
Ogino Ginko (3 March 1851 – 23 June 1913) was the first registered female doctor to practise modern medicine in Japan.
Japanese geochemist Katsuko Saruhashi developed the first method and tools for measuring carbon dioxide in seawater