Japan

Researchers at The University of Osaka and The University of Tokyo developed a photoactivatable alkyne tag that enables stable, selective visualization of biomolecules inside living cells. The technology would contribute to reveal previously unseen molecular communication, paving the way for advances in cell biology and drug discovery.

A new study suggests that the same henna pigments that change your skin or hair that distinctive orange-red color could be used for another purpose: treating liver disease.

Merging Molecular Biology and Photochemistry for Breakthrough Innovation

A collaboration team of researchers from the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, the Institute of Transformative Bio-Molecules (WPI-ITbM), Graduate School of Science at Nagoya University, and the RIKEN Center for Computational Science (R-CCS) reports in ACS Nano an integrative modeling workflow to understand with atomistic precision biomolecular dynamics from high-speed atomic force microscopy experiments.

An international team has provided experimental evidence of bulk altermagnetism in MnTe. Using resonant X-ray nanoimaging, they resolved magnetic domains and confirmed their altermagnetic nature, establishing a powerful tool for future 3D and real-time studies of magnetic textures.

In 1867, Lord Kelvin imagined atoms as knots in the aether. It was soon disproven. But a new study suggests his discarded idea may yet hold the key to why the universe exists.

The University of Osaka researchers developed a world-first sustainable method for synthesizing pharmaceutical-grade NOBIN. By cooperatively utilizing a vanadium catalyst and energy-efficient LED light, the process eliminates byproducts, reduces waste, and allows for ideal raw material ratios, paving the way for greener and more efficient chiral molecule production.

In the marine green alga Codium fragile, unusual carotenoids rapidly dissipate harmful chlorophyll triplet states, protecting the organism from light-induced damage. Using EPR spectroscopy and quantum chemical simulations, the study revealed the structural and electronic principles behind this photoprotection, offering insights for potential bio-inspired solar technologies.

Researchers at Tohoku University synthesized a graphene mesosponge to pinpoint the cause of battery failure, so that we can fix the root cause of their instability.

A research team led by Associate Professor Tomoya Kataoka at Ehime University, in collaboration with Yachiyo Engineering Co., Ltd., Nippon Koei Co., Ltd., and Wageningen University’s Associate Professor Tim van Emmerik, has developed AI software using deep learning to detect, classify, and track plastics flowing in rivers. The system automatically estimates transport volumes from video data, supporting continuous monitoring and advancing understanding of land-to-sea plastic transport. The findings appear in Water Research.

A Hiroshima University ecologist proposes a flexible anytime, anywhere bird survey approach to expand biodiversity data collection

Researchers at Tohoku University have taken a major step forward in the global hunt for dark matter, an invisible substance that makes up about 27% of the universe, by designing a new type of quantum sensor network that could significantly improve our chances of detecting it.

Modified yeast developed to efficiently adsorb targeted elements from solutions

Lab tests confirm that Pin1 inhibitors could reduce and stop outbreaks of herpes simplex virus-1

Researchers from The University of Tokyo have found that single cells in collective chemotaxis act like agents in distributed reinforcement learning, utilizing the environment as an “external memory” and exhibiting highly intelligent behavior.

Researchers found overlooked sources of greenhouse gas emissions in urban Osaka using mobile measurements

The precise placement of a single silver atom can be enough to make a huge difference. Researchers found that light-emitting properties were 77 times more efficient as a result – paving the way for better optoelectronics and sensing technologies such as OLED lights.

The University of Osaka scientists have developed a safe, efficient “dump-and-stir” method to introduce ortho-carborane into various aromatic compounds using a newly designed lithium–copper reagent. This innovation overcomes the complexity and hazards of previous methods, paving the way for new applications in boron neutron capture therapy (BNCT), three-dimensional aromatic materials, and bioisosteric drug design.

Researchers at The University of Osaka discovered that the protein TMEM217 is essential for sperm motility and male fertility. TMEM217 stabilizes a protein complex that produces the signaling molecule cAMP, which powers the sperm’s tail. Mice lacking TMEM217 have immotile sperm, but treating the sperm with a cAMP-like molecule restored motility and fertility via IVF. This finding opens doors for new diagnostics and therapies for male infertility.

Researchers from The University of Osaka in collaboration with Baylor College of Medicine have developed a new therapy for a severe form of male infertility called non-obstructive azoospermia (NOA). Using lipid nanoparticles (LNPs) to deliver specific mRNA into the testes of infertile mice, they were able to restart sperm production. The sperm produced were then used in intracytoplasmic sperm injection (ICSI) to successfully generate healthy and fertile offspring. The findings provide a crucial proof-of-concept for treating male infertility caused by genetic defects.

Researchers at The University of Osaka have discovered precursor T follicular regulatory cells (preTfr), comprising 30-50% of circulating Tfr in human blood. preTfr are significantly reduced in severe COVID-19 and sepsis, correlating with increased anti-interferon-gamma autoantibodies and activated atypical B cells. Unlike stable conventional naïve regulatory T cells, preTfr are specifically depleted during severe disease. When stimulated, preTfr up-regulate suppressive molecules including IL-1RA and show enhanced wound healing capacity. Conversely, mRNA vaccination increases preTfr frequency, suggesting controlled immune participation. The findings identify preTfr as a therapeutic target for preventing autoantibody production during severe infections.

Researchers at Tohoku University have made a magnesium battery prototype that represents the potential next stage in energy storage - a fast-charging battery made from sustainable materials.

2025 Nobel Laureate in Physiology or Medicine Professor Shimon Sakaguchi at the Immunology Frontier Research Center, The University of Osaka delivered his message on 6 October 2025.

An international research team revealed how we could use Germanium-Tin (GeSn) in highly efficient semiconductors – which could benefit a plethora of everyday technologies.

Researchers from The University of Osaka have developed a polymeric adhesion system by introducing reversible bonds at the adhesion interface based on the formation and dissociation of host–guest complexes. The adhesive can be decomposed on demand using temperature or chemicals and reused multiple times. Visualization of the interface using neutrons revealed the mechanism underlying repeatable sticking and peeling. This technology can be used for sustainable material applications.

With so many environmental issues arising, how can we even begin trying to solve them all? Perhaps, we can start by asking AI. This study highlights how AI can pinpoint viable action plans for these issues.

Having a good leader–follower relationship matters, but only when people spontaneously choose their roles

A rock described as a flaky pastry may sound delicate, but researchers at Tohoku University found that when they fold under compressive forces in just the right way, they can actually be strong. These findings may help with earthquake risk assessment.

Study reveals a gap between willingness and actual use among people with poor health

The University of Osaka researchers developed a reinforcement learning framework that lets dialogue systems efficiently learn new words while asking fewer questions. This approach enhances user experience and enables future systems to naturally acquire family-specific nicknames and expressions, becoming more familiar companions in everyday life.