Japan

By just sprinkling it on top and waiting 10 seconds, researchers can use this new fluorescent probe to clearly show synapses, the connection points between brain cells.

Researchers from The University of Osaka have identified key genetic mutations linked to extracranial arteriovenous malformations (AVMs), a rare and potentially serious vascular disorder. They have revealed that these mutations activate the RAS/RAF/MEK signaling pathway and that the MAP4K4 gene may drive pathological angiogenesis. This may mean that existing cancer drugs that target the same pathway could be effective for AVM treatment, potentially paving the way for novel therapies.

Nonlinear quantum dynamics are complicated, but they don’t have to be. A new, real-time simulation may help demystify these unusual dynamics, serving as a guide to develop next-gen quantum devices.

Researchers from The University of Osaka found that a one-time genome editing treatment introducing a gene encoding the glucagon-like peptide-1 receptor agonist Exendin-4, marketed as the weight-loss drug Exenatide, results in sustained secretion of the drug, reduced food intake, and enhanced weight loss in mice. This in vivo genome editing approach provides a potential strategy for treating complex diseases without defined genetic causes, such as heart disease and autoimmune disorders, without the need for frequent medication.

Spatial and seasonal variations of polychlorinated biphenyl (CB-153) in the Seto Inland Sea and its response to declines in atmospheric and riverine input

Hyperconjugation between aromatic rings and their side chains to stabilize unpaired electrons

New study explains why too much ultrasound slows chemical reactions

Distribution characteristics and transport processes of biodegradable microplastics in the Seto Inland Sea, Japan

Machine learning potential can create accurate, large-scale models of catalytic activity for a reaction that turns carbon dioxide into a sustainable energy source.

A new way to grow stem cells may help them release more of the signaling proteins they use to repair tissue, potentially improving future treatments.

Cell sheet preparation for use in tissue engineering and regenerative therapies could be significantly improved with the use of thermo-responsive polymer brushes, adjusted in length and density according to specific cell types

Using a global ocean model, researchers from the Institute of Industrial Science, The University of Tokyo, and the Institute of Environmental Radioactivity, Fukushima University, found that short- and long-term contribution of treated water released from the Fukushima Daiichi Nuclear Power Plant on oceanic tritium concentration beyond the vicinity of the discharge site is negligible, even in climate change scenarios

Comparing picosecond and nanosecond lasers usage with a newly developed index

Researchers from SANKEN, The University of Osaka, have revealed a technique for exploiting the catalytic action of hydrogen in platinum to reverse the degradation of magnetization. This method can be used to increase the robustness of next-generation computer chips based on thin magnetic films.

Researchers from The University of Osaka have developed a method to visualize and reconstruct individual urban plants in different seasons using AI and street view images. The novel Seasonal Species-Specific Plant View Index allows urban designers to enhance the ecological sustainability and the well-being of city dwellers by incorporating diverse plant configurations, colors, and seasonality into current and future urban green spaces.

Findings based on efforts in Sera Town, Japan showed the pneumococcal vaccination support program reversed the previously increasing trend in pneumonia mortality rate in the community.

Barth syndrome is a rare genetic disorder with no known cure. Researchers at Tohoku University examined a new oral drug called MA-5 that could provide life-changing relief to these young patients.

Dietary prebiotics may induce an increase in brain GABA levels through the regulation of gut microbiota, which can be a major point for reducing or even treating these occurrences of certain neurological diseases in individuals.

Inspired by a simple children's toy, a jumping popper toy, researchers have unlocked a key to designing more agile and predictable soft robots. Soft robots, made from flexible materials, hold immense promise for delicate tasks, but their complex movements have been difficult to predict and control, especially dynamic actions like jumping. Now, a team from Keio University and The University of Osaka has published a study in Advanced Robotics Research detailing the physics behind the jump of thin hemispherical shells, a fundamental building block for jumping soft robots.

Researchers from the Institute of Industrial Science, The University of Tokyo, have developed nanoscale ‘molecular flasks’ based on single molecules of bottlebrush polymers to carefully control polymerization reactions in extremely small spaces

Lifesaving deep learning model developed using standard radiographs

Researchers from The University of Osaka observed the reactions of Japanese macaques to the deaths of their companions. They found that some macaques remained near and even groomed the dead, especially if they had been close companions. These findings suggest that macaques, like humans, may exhibit emotion-based responses to death.

Researchers at the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, report in Small, a weekly peer-reviewed scientific journal covering nanotechnology, published by Wiley-WCH, Germany, how short peptides self-assemble linearly on atomically-thick solid surfaces, such as graphite and MoS₂. The research addresses a longstanding challenge in materials science: understanding the complex, sequence-specific interactions between peptides and solid substrates, and the critical role of local hydration structures in guiding nanoarchitecture formation. This work offers new strategies for integrating biomolecules with advanced materials in future bioelectronics and sensor devices.

A groundbreaking study led by a global research consortium offers new hope for patients with mycetoma, a neglected tropical disease. Researchers using an insect model and transcriptome analysis have unravelled the mechanism of iron regulation between host tissue and the mycetoma grain, a fungal mass characteristic of the disease. This discovery illuminates how the causative fungus invades and develops these protective grains within subcutaneous tissue, paving the way for new drug development and less invasive treatment strategies beyond surgical removal, potentially reducing the burden on patients significantly.

Researchers from The University of Osaka found that both inhibitory and activating killer immunoglobulin-like receptors on natural killer (NK) cells were able to bind repetitive interspersed family proteins expressed on the surface of malaria-infected red blood cells. The role of these proteins in triggering both inhibitory and stimulatory responses from NK cells makes them extremely promising targets for the development of therapies and vaccines for malaria.

Stress-responsive gene pushes pancreatic insulin-producing cells toward dysfunction, fueling diabetes

How halogens uncover the hidden history of lunar crust formation and the striking lunar surface dichotomy.

Using iPS cells, veterinary medicine has made a step forward in creating a stable MSC supply

Researchers from The University of Osaka have developed a way to efficiently prepare the “magic states” necessary for quantum computers to be resistant to errors. Their technique, called “zero-level distillation,” involves working with qubits at the physical or zeroth level as opposed to higher, more abstract levels. The spatial and temporal overhead of quantum computers prepared from these states using this technique is around several dozen times lower than that of those prepared from conventional methods.

Serendipitous discovery of djerfisherite in Ryugu grain challenges current paradigm of the nature of primitive asteroids.