Japan

tRNA-MaP can rapidly analyze the specificity of tRNA m1A22 methyltransferase (TrmK) for substrate tRNAs.

Scientists reveal genetic mechanism associated with high-calorie food-fueled obesity

The ability to see what’s happening inside the body in real-time and at a high resolution is a capability that ultrasound grants orthopedists at a low cost to patients. Ultrasound-guided diagnosis, however, remains relatively new in the field. Dr. Yuko Nakashima is here to change that for Japan with the help of her fellow “e-girls.”

A research team led by Osaka Metropolitan University has revealed a difference in neural activity in response to visual food stimuli, depending on whether those stimuli are presented consciously or unconsciously. Using a questionnaire to assess the study participants, the team found that this difference was associated with their scores on eating behaviors, including emotional eating and cognitive restraint of food intake. These results indicate that eating behavior cannot be understood without taking into account both unconscious and conscious neural processes.

Osaka Metropolitan University scientists discovered the principle of light-induced acceleration of antigen–antibody reaction, allowing for simple, ultrafast, and highly sensitive detection of proteins. The researchers introduced target proteins and probe particles with modified antibodies selectively binding to the target proteins into a small channel and applied irradiation with infrared laser light. They achieved, for the first time, the rapid measurement of trace amounts of attogram-level target proteins after only 3 minutes of laser irradiation. These findings will potentially contribute to breakthroughs in the development of systems for ultra-early diagnosis of various diseases.

Researchers have designed and synthesized analogs of a new antibiotic that is effective against multidrug-resistant bacteria, opening a new front in the fight against these infections.

Researchers from Osaka University found that the “belief in just deserts”, which is the idea that infected individual deserves to be infected, was associated with attitudes about government restrictions during public health emergencies in the context of the COVID-19 global pandemic. This information could lead to new strategies for combating discrimination, prejudice, and stigma against COVID-19 patients.

Sound velocities of superhydrous phase B and the presence of water in the Earth’s mantle

The Kuroshio regulates the air-sea exchange of PCBs

An Osaka Metropolitan University scientist measured the light transmittance of the eyelids when the eyes are closed, and found that perceived closed-eye brightness is significantly stronger than previously reported. The influence of color was also observed, with red light perceived as brighter and blue light perceived as darker. Additionally, there were significant differences between experimental participants; for some, their perception of brightness barely differed between open- and closed-eye conditions.

Researchers from Osaka University have developed a culture system using pluripotent cells from southern and northern white rhinos, which was refined to produce primordial germ cell-like cells (PGCLCs). These cells are the equivalent of primordial germ cells, the origin of eggs and sperm. The study marks an important first step in the potential production of northern white rhino gametes, which could be used in breeding programs, and is the first to induce PGCLCs in a wild animal.

Scientists developed a novel device that predicts whether an ICU patient taken off mechanical ventilation is likely to suffer from respiratory emergencies, helping critical care teams to provide immediate life-saving interventions.

Researchers led by Osaka University report the development of INCIDER, a fluorescent sensor system that enables high-contrast microscopic imaging of temporal changes in cellular interactions mediated by the N-cadherin molecule. This sensor system, which emits much brighter fluorescence than the currently used system while detecting these interactions, is expected to have a wide range of applications in developmental biology, neuroscience, and other fields.

Training individuals to inhibit imitation of others increases empathy and allows them to recognize facial expressions in others regardless of their situations.

Using cryogenic electron microscopy, a research team from the Research Center for Artificial Photosynthesis (ReCAP) at Osaka Metropolitan University has revealed, for the first time, the structures and binding environments of pigments bound to a protein called a photosynthetic antenna of the marine green macroalga Codium fragile. The team’s results extend our knowledge about the molecular mechanism by which blue-green light—the only light available in deep seawater—is efficiently utilized for photosynthesis.

Researchers led by Osaka University generated a time-stamping method to trace the development and survival of plasma cells in the bone marrow and spleen. Using a mouse model in which plasma cells were fluorescently labeled in an inducible manner, they found that plasma cells were continuously replenished by new cells, a small portion of which differentiated into long-lived plasma cells (LLPCs). These findings may aid in the development of new vaccines that efficiently induce LLPCs.

Researchers at The University of Tokyo develop a simple but effective method of bonding polymers with galvanized steel, a material ubiquitous in the automobile industry, to cheaply and easily create a lightweight and durable product.

A research group at Osaka Metropolitan University has discovered that 2,5-distyrylpyrazine (DSP) crystals undergo a unique photoreaction. Normally, photoreactive color changes proceed uniformly throughout photomechanical molecular crystals, so that all parts of each crystal change color at the same time. However, when light shines evenly on a DSP crystal, the photoreaction propagates from edge to center, deviating from conventional photochemistry models. The group found that this phenomenon was caused by a surface effect and a cooperative effect, which make reactivity extremely high for molecules at the crystal’s edge and those adjacent to molecules that have already changed color.

A study by Osaka University has shown that the prevalence of non-communicable diseases, which included hypertension, hyperlipidemia, diabetes, and mental disorders, increased after the Fukushima disaster and the COVID-19 outbreak. These findings emphasize the importance of improving post-disaster health promotion strategies and recommendations.

Researchers at The University of Tokyo show how including the effects of the surrounding water during the aggregation of charged particles can improve the accuracy of simulations, which may help elucidate biological self-assembly

Revelations about the mechanisms of two key proteins which maintain the asymmetric distribution of cholesterol within the cell membrane could help understand and treat diseases linked to its imbalance

Scientists investigate how genes in some insects can influence one another to change their expression depending on environmental conditions.

Reef corals provide an accurate, high-resolution record of the influence of the El Niño Southern Oscillation on rainfall, flooding and droughts in the Mekong River Delta, Vietnam.

World's first research into relationship between rich-in-biodiversity garden greenery and health/well-being launched by University of Tokyo and Sekisui House Ltd.

Studying an atomic clock on-board a spacecraft inside the orbit of Mercury and very near to the Sun could be the trick to uncovering the nature of dark matter.

Machine learning and robotic process automation combine to speed up and simplify a process used to determine crystal structures.

Precise control of quantum systems, such as quantum computers, is of great importance for modern quantum science. One way this has been done is via spin echoes. A research group has discovered a new type of echo, labelling them “energy-band echoes.”

Automated reaction path search method predicts accurate stereochemistry of pericyclic reactions using only target molecule structure.

Therapeutically superior mesenchymal stem cells derived from the cranial bone offer hope in reversing paralysis and language impairment in moderate to severe cases of stroke.

Osaka Metropolitan University researchers introduced seven proteins, thought to let bacteria swim by switching the direction that their helical bodies spiral, into a strain of synthetic bacterium with minimal genetic information. As a result, they confirmed that the synthetic bacterium named syn3, which is normally spherical, formed a helix that could swim by spiraling. Further investigation revealed that only two of these newly added proteins were required to make syn3 capable of minimal swimming. This swimming synthetic bacterium can be said to be the smallest mobile lifeform genetically, as it contains the fewest number of genes.