Japan

Research performed on human blastoids, a research model of an early embryo built out of stem cells, may allow scientists to understand better what causes birth defects and lost pregnancies, and so prevent them. But such research is also ethically fraught, warn bioethicists, due to differing beliefs on whether the blastoid possesses sentience or has the potential to do so.

Researchers analyzed how the specific components of peace and environmental sustainability — concepts known to be intrinsically related but often investigated separately — influence each other to better inform policy and decision-making.

Osaka University researchers showed how to use laser beam interference to construct chiral structures. By using computer simulations, they were able to predict the final light pattern and optical radiation force distribution of any collection of light sources. This work may lead to cheaper optical devices and sensors.

Hokkaido University researchers find a new way of producing the industrially important propylene that is more energy efficient than existing approaches—and in the process turns carbon dioxide into another usable resource. Their pioneering catalyst design thus contributes to the carbon neutralization of the petrochemical industry.

A team of researchers have analyzed the elemental composition of asteroid Ryugu using an artificially generated muon beam from a particle accelerator.

Chaos theory improves understanding of Arctic narwhal behavior, with the aim of helping efforts to protect this vulnerable species.

Researchers led by Osaka University developed a novel fluorescent sensor to detect and monitor levels of the neuropeptide oxytocin, also known as the “happy hormone.” The OT sensor facilitated the successful measurement of OT dynamics in the brains of living animals and may serve as a foundation for the development of therapeutics for the treatment of neurological disorders such as autism and schizophrenia.

Researchers at The University of Tokyo grow a nanoscale layer of a superconducting material on top of a nitride-semiconductor substrate, which may help facilitate the integration of quantum qubits with existing microelectronics

Researchers from The Institute of Industrial Science, The University of Tokyo have developed a streamlined photo-uncaging system for photodynamic cancer therapy, using a pulse of light for tumor-specific activation of a cancer-fighting agent

A research group led by the Institute of Industrial Science, The University of Tokyo, finds that sensory neurons in human skin modulate melanocytes via the secretion of Repulsive Guidance Molecule B

The activity of deep-focus earthquakes, which increases with depths from ~400 km to a peak at ~600 km, is enigmatic because conventional brittle failure is unlikely to occur at elevated pressures. Our experiments showed that formation of thin weak layers filled with nano-crystalline olivine/wadsleyite, upon the pressure-induced phase transition of olivine, is the major cause of deep-focus earthquakes on the metastable olivine wedge in deep slabs.

Researchers found a new way to reduce carbon dioxide (CO2) emissions by wrapping copper nanocubes with an organic layer, solving instability and selectivity problems with copper nanocubes in catalysis, and improving how this electrocatalyst converts CO2 into organic molecules.

Osaka University researchers identified the specific protein complex that recognizes when cellular organelles called lysosomes become damaged. When this occurs, the CUL4A protein complex transfers a molecular tag, called polyubiquitin, to a lysosomal protein known as LAMP2. WDFY1, another protein in the complex, is able to recognize and interact with LAMP2. These initial steps are critical to beginning a process called lysophagy, in which these damaged lysosomes are cleared away by the cell.

Scientists from The University of Tokyo formulated nonlinear, nonequilibrium energy dissipation relationships using methods from geometry to better understand the kinetics of irreversible chemical processes

Researchers develop a new integrated framework that factors in the many variables relevant to accurate carbon emissions modeling in the transportation sector, allowing for policymakers to choose the best path to achieve carbon neutrality.

It is commonly believed that patients with chronic kidney disease should limit their protein intake given that excessive protein worsens kidney function. However, a new study by Osaka Metropolitan University scientists indicates that changes in skeletal muscle mass are positively correlated with protein intake, suggesting the necessity of adequate protein intake to improve muscle mass after kidney transplantation.

A team of researchers including Kavli IPMU has found people in Japan, US, and Germany show different concerns regarding Artificial Intelligence (AI) being used in entertainment, shopping services, or to help find criminals.

Demonstration of embodied cognition mechanisms in the brain could have implications for artificial intelligence.

An estimated 1208 excess suicide deaths for men and 1825 for women were recorded during the COVID-19 Pandemic in Japan through December 2021, with the impact being greatest in women and younger age groups.

Research shows that natural catastrophes may trigger or exacerbate attacks of incapacitating migraine in disaster victims.

An international research team led by scientists from Osaka Metropolitan University has developed a method to identify symmetries in multi-dimensional data using Bayesian statistical techniques. Bayesian statistics has been in the spotlight in recent years due to improvements in computer performance and its potential applications in artificial intelligence. However, this statistical approach requires complex calculations of integrals, which are often considered approximations only. In their new study, the research team successfully derived new exact integral formulas. Their findings contribute to improving the accuracy of methods to identify data symmetries, possibly extending their applications to wider areas of interest, such as genetic analysis.

Researchers at The University of Tokyo create a geometric representation of thermodynamic systems and apply it to self-replicating processes, which may help improve our understanding of the physical constraints of living organisms

Osaka Metropolitan University scientists developed a new method to isolate hepatic stellate cells (HSCs), which play a significant role in liver cancer progression. With enzymatic cold perfusion and utilization of an antibody against CD49a, a reliable HSC surface marker, the new method allows HSC isolation with high yield and purity from livers with various conditions, be they normal or fatty tumor-prone, from both mice and humans. The findings are expected to contribute to the development of efficient tools for characterizing NASH- or fatty liver-based liver cancer.

Researchers study sex-determination in birds using primordial germ cells and RNA-sequencing analysis.

Researchers at Hiroshima University are closer to identifying the molecular processes underlying how floods deprive plants of oxygen — and how to engineer hardier crops.

To automatically generate data for training deep convolutional neural network models to segment building facades, researchers from Osaka University used a three-dimensional model and game engine to generate digital city twin synthetic training data. They found that a model trained on these data mixed with some real data was competitive with a model trained on real data alone, revealing the potential of digital twin data to improve accuracy and replace costly manually annotated real data.

Scientists have quantified the glacier mass loss on the Kamchatka Peninsula; the accelerated loss in the region since the turn of the millennium is likely to increase in the short term.

Researchers from Osaka University have found that photoperiod variation in bean bugs is regulated by genes involved in maintaining circadian rhythm via the neurotransmitter glutamate. The discovery of this mechanistic link between the biological clock and seasonal variation may have important implications for seasonal adaptation in other animals, given the conservation of glutamate across many species.

Researchers have used giant lobes of gamma radiation to find that a small satellite galaxy of the Milky Way filled with dark matter, but whose emissions are more likely the result of millisecond pulsars blasting out cosmic particles.

The research team directed by H. Shimomoto and E. Ihara in Ehime University successfully developed a new Pd-based initiating system affording carbon–carbon main-chain polymers bearing end-functional groups. This achievement will contribute to progress in the field of polymer chemistry and will allow us to develop new types of functional polymers.