Japan

A new technique allows researchers to map how the cellular “skeleton” adapts to external stress.

Researchers from Osaka University have found that, after chronic social isolation, one form of ketamine—(R)-ketamine—is effective for restoring neuronal activation in a brain region known as the anterior insular cortex. This restored activation leads to improvements in social impairments in a mouse model of depression. Together, these findings indicate that (R)-ketamine is a promising treatment for social symptoms of depression and may lead to better quality of life for millions of people worldwide.

Innovative technology for the comprehensive analysis of membrane protein extracellular interactions.

Researchers from Nano Life Science Institute (WPI-NanoLSI), Kanazawa University report in Nature Communications that TMEM16F, a transmembrane protein that facilitates the passive movement of phospholipids and ions across membranes, explores a larger conformational landscape than previously thought to perform its unique functions. The finding refines our molecular understanding of crucial physiological processes such as blood coagulation and COVID-19 pathogenesis, and highlights the importance of probing membrane proteins in native-like environments.

The effects of a phenomenon called tree masting on ecosystems and food webs can be better understood thanks to new theoretical models validated by real world observations.

Regenerative therapy to treat heart failure is more effective when the mitochondria of the regenerative cells are activated prior to treatment.

In a study recently published in Nature Genetics, researchers from Nano Life Science Institute (WPI-NanoLSI), Kanazawa University explore chromatin accessibility, i.e., endogenous access pathways to the genomic DNA, and its use as a tool for gene editing.

Researchers at Kanazawa University report in Journal of Cell Science on a novel role of the small Ca2+-binding protein S100A11 in focal adhesion disassembly.

Researchers at Osaka Metropolitan University assess why post-operative symptoms such as pins and needles, sudden cold, burning, itching, and numbness in the limbs remain in patients suffering from cervical spondylotic myelopathy, even after surgery. The researchers also evaluated the patients’ satisfaction with postoperative treatment. They found that it was lower for those who still had paresthesia in their hands and feet, regardless of whether their motor symptoms had improved or not.

Coordination polymer crystals show promise as a new generation of light sources for industry and medicine.

A new method allows scientists to gather enough information about the properties of metals to enable the prediction of the properties of new materials.

Researchers from Osaka University found that the oral bacterium Streptococcus gordonii activates another bacterial species, Fusobacterium nucleatum, to produce large quantities of methyl mercaptan, a compound responsible for bad breath. Disrupting this interaction could therefore help treat halitosis, and possibly also help prevent the development of more serious tooth and gum disease.

Vaccines and therapies based on messenger RNA could be more readily delivered due to a non-toxic polymer that protects RNA and controls its release inside cells.

Researchers from Osaka University and collaborating partners succeeded in biomanufacturing from chemically synthesized sugar for the first time in the world. With refinement of this technology, one can envision a future society in which the sugar required for biomanufacturing can be obtained "anytime, anywhere, and at high rate". In the future, biomanufacturing using chemically synthesized sugar is expected to be a game changer in the biotechnology field—including the production of biochemicals, biofuels, and food, where sugar is an essential raw material—ultimately leading to the creation of a new bio-industry.

An innovative and more efficient way to produce fumaric acid that not only reduces carbon dioxide emissions, but also reuses waste resources to make biodegradable plastics

Researchers from Osaka University have found that gargling with an antiseptic mouthwash can reduce so-called ‘bad’ bacteria in the mouths of patients with type 2 diabetes. Notably, this reduction in bacteria was accompanied by improved blood-sugar control in some patients. Given that the oral diseases caused by these bacteria have been linked to many other serious inflammation-associated diseases, such as cardiovascular disease and Alzheimer’s disease, this simple treatment may have widespread effects.

The properties of supramolecular polymers are dictated by the self-assembled state of the molecules. However, not much is known about the impact of morphologies on the properties of nano- and mesoscopic-scale polymeric assemblies. Recently, a research team demonstrated how terminus-free toroids and random coils derived from the same luminescent molecule show different photophysical properties. The team also presented a novel method for purifying the toroidal structure.

Researchers from the Institute of Industrial Science, The University of Tokyo have solved a foundational problem in transmitting quantum information, which could dramatically enhance the utility of integrated circuits and quantum computing.

Researchers including Kavli IPMU have used equipment originally intended for astronomy observation to capture transformations in the nuclear structure of atomic nuclei, reports a study in Scientific Reports.

A trained AI system learns to design cellular materials with specific target properties for a wide range of potential uses, including tissue engineering and energy storage.

A new coating for tiny vaccine carriers allows vaccines to remain in the body for longer.

Yokohama National University scientists are working towards creating a better tomorrow by addressing diverse challenges, from snow algae and tropical cyclones to AI cyberthreats, and much more.

Theoretical predictions have been confirmed with the discovery of an outflow of molecular gas from a quasar when the Universe was less than a billion years old.

Researchers from Osaka University and IMRA AMERICA demonstrated a 300 GHz-band wireless link that was able to transmit data over a single channel at a rate of 240 gigabits per second. The wireless communication system employs signal generators based on lasers that have ultra-low phase noise in the sub-terahertz band. This rate is the highest so far reported at these frequencies and is a substantial step forward in 300 GHz-band communications for 6G networks.

A team of researchers from Osaka Metropolitan University assessed the feasibility of conducting cardiopulmonary exercise testing with the upper limbs as an alternative to the conventional method that uses the lower limbs. The researchers investigated the relationship between heart rate and oxygen uptake during exercise stress tests using a cycle ergometer and an arm crank ergometer, and estimated maximal oxygen uptake. The study participants were 17 male collegiate athletes from rowing and cycling clubs. The results showed that the estimated maximal oxygen uptake for both rowing and cycling groups was lower on the arm crank ergometer than on the cycle ergometer. Additionally, this study showed that exercise testing using an upper extremity ergometer underestimates cardiopulmonary function, regardless of upper limb training status.

A new technology to increase visibility of cancer cells to the immune system using CRISPR has been developed, and could lead to a new way to treat cancer.

A theoretical framework for measuring the Reynolds similitude in superfluids could help demonstrate the existence of quantum viscosity

Corrugated wings exhibit larger lift than flat wings

Researchers from SANKEN (The Institute of Scientific and Industrial Research), at Osaka University developed an optical sensor consisting of carbon nanotube photodetectors and organic transistors formed on an ultrathin, flexible polymer film. A wireless system reads the images from the sensor. Experiments showed the sensor has high sensitivity, a wide bandwidth, and robustness to extreme deformation such as bending and crumpling. This sensor has high potential for use in applications such as non-destructive imaging, non-sampling liquid quality evaluation, wearable devices, and soft robotics.

A water-soluble, luminescent europium complex enables evaluation of malignancy grade in model glioma tumor cells.