Japan

A research group at Osaka Metropolitan University has derived a new evaluation method for the measuring the size X-ray microbeams (diameter) through mathematical analysis. The group then verified the validity of the mathematically derived evaluation method by measuring the diameter of X-ray microbeams using metal wires of various diameters with an X-ray fluorescence analysis system for small areas and found that it was possible to calculate the beam diameter more accurately than the previous conventional evaluation method.

Two catalysts working in tandem enable inexpensive formate salts to perform difficult dearomative reactions, giving products potentially useful for drug development.

Researchers led by Osaka University used cryogenic electron microscopy to analyze the atomic structure of the centromeric region of the chromosome, essential for cell division. A protein called CENP-A marks the centromere; the researchers showed that during interphase, CENP-A is bound by a protein called KNL2 to maintain the location of the centromere. During mitosis, KNL2 is replaced by CENP-C, allowing correct formation of the kinetochore complex for cell division.

Researchers from Osaka University expanded the synthetic toolkit for preparing valuable chemical precursors from renewable feedstocks. They used microwave irradiation to dramatically improve the selectivity of the formose reaction, forming a simple six- and seven-carbon mixture that can be readily purified. These findings will help the chemicals industry minimize the use of fossil resources and improve the sustainability of manufacturing processes.

Researchers used the James Webb Space Telescope to identify the precise location of a powerful energy source hidden by cosmic dust in the luminous merging galaxy IIZw096.

Researchers used a chemical synthesis robot and computationally cost effective A.I. model to successfully predict and validate highly selective catalysts.

Researchers from Osaka University have used single carbon atom doping to form four chemical bonds in one step. Gamma-lactams (cyclic molecules that are common in antibiotics) were easily synthetically accessible from alpha, beta-unsaturated amides (an important molecule in cancer progression). The team chemically modified an anti-seizure medication in 96% yield, highlighting the work's utility to otherwise synthetically complex aspects of pharmaceutical development. The results of this work could become foundational to drug discovery and development.

A new microscopic technique allows for the real-time study of RNA G-quadruplexes in living cells, with implications for the fight against amyotrophic lateral sclerosis.

Osaka University researchers investigated the physics of laser-driven neutron sources, and found the relationship between the power and the neutrons generated. They were able to decrease the exposure time needed for neutron absorption experiments, which may be employed in biomedical research.

A research group at the Osaka Metropolitan University Graduate School of Informatics has developed a new learning method for artificial intelligence that combines classification performance for data with multiple labels with the ability to learn continually from data. Numerical experiments on real-world multi-label data indicate that the new method outperforms conventional approaches. The simplicity of this algorithm makes it easy to integrate it with other algorithms to devise new ones.

Data stored in ice cores dating back 55 years bring new insight into atmospheric levels of a molecule that can significantly affect weather and climate.

Researchers from Osaka University have shown that a system known as the GET pathway is essential for efficient mitophagy, the process by which mitochondria are removed from cells. The GET pathway targets a protein assembly called the Ppg1–Far complex, which inhibits mitophagy, to the membrane of a part of the cell called the endoplasmic reticulum. When the GET pathway is defective, this complex instead becomes targeted to mitochondria, where it acts to suppress mitophagy.

Researchers from Osaka University compared the sensitivity of rapid antigen tests (RATs) and polymerase chain reaction (PCR) tests for the Omicron variant of COVID-19 using data produced by the Japan Professional Football League. They found the comparative sensitivity of RATs for Omicron was not affected by the duration from the onset of symptoms to testing.

A “back-projection” technique reveals new details of the volcanic eruption in Tonga that literally shook the world.

New research found that periodontitis, a common gum infection known to worsen other systemic diseases, could also be linked to atrial fibrosis — potentially clarifying its previously unknown connection with atrial fibrillation.

Researchers from Osaka University have identified a protein, FER1L5, that is essential for sperm to acquire fertilizing ability. Sperm from mice lacking this protein were unable to undergo the “acrosome reaction”, which releases molecules that facilitate fertilization, resulting in impaired male fertility. As FER1L5 is also present in human sperm, this work may lead to new diagnostic methods and treatments for male infertility in humans.

Osaka Metropolitan University scientists have succeeded in synthesizing fumaric acid, a raw material for plastics, from CO2 powered by solar energy—for the first time. Typically, fumaric acid is synthesized from petroleum as a raw material to make polybutylene succinate, a biodegradable plastic, but this research shows that it can be synthesized from CO2 and biomass-derived compounds using renewable energy.

Researchers from Osaka University created a bound state of a proton and a K- meson known as Λ(1405), and measured its mass. The data implied that it consisted of five quarks. This work may help scientists develop a theory of exotic matter that existed in the early Universe or in neutron stars.

A research group, at the Osaka Metropolitan University Graduate School of Engineering, has succeeded in measuring spin transport in a thin film of αNPD molecules—a material well-known in organic light emitting diodes—at room temperature. They found that this thin molecular film has a spin diffusion length of approximately 62 nm, a length that could have practical applications in developing spintronics technology. In addition, while electricity has been used to control spin transport in the past, the thin molecular film used in this study is photoconductive, allowing spin transport control using visible light.

New research from Osaka University indicates that more screen time at age 2 is associated with poorer communication and daily living skills at age 4—but when kids also play outdoors, some of the negative effects of screen time are reduced. Increasing outdoor play time could reduce the negative effects of screen time on daily living skills by almost 20%.

The natural abilities of squid tissues and the creativity of chemists combine to take hydrogel research in new directions.

Researchers at Kanazawa University report in Nano Letters how high-speed atomic force microscopy can be used to assess the effectivity of spike-neutralizing antibodies for preventing COVID-19. The use of such antibodies offers a promising alternative to vaccines.

In a study recently published in Cancer Science researchers from Kanazawa University show how some intestinal cancer cells lose their ability to spread as they divide and can be eliminated as the cancer grows.

Understanding how dust grains form in interstellar gas could offer significant insights to astronomers and help materials scientists develop useful nanoparticles.

Researchers led by Osaka University demonstrated the role of endothelial cell-specific protein Roundabout4 (Robo4) in the reduction of vascular permeability and mortality in mouse models of severe infection. The research team identified a drug inhibitor that increased Robo4 expression and reduced mortality in sepsis and SARS-CoV-2 mouse models of infection. These findings may aid in the development of drugs to reduce the mortality rate of severe infectious diseases.

An Osaka Metropolitan University research group recorded the autonomic nervous system activity in patients with irritable bowel syndrome (IBS) and healthy subjects using a wearable device and a proprietary smartphone application to record daily life events such as defecation and sleep. As a result, they found that sympathetic nervous system activity was activated in IBS patients from 2 minutes before defecation and continued until 9 minutes after defecation. Further research is expected to improve the quality of life of IBS patients and elucidate the pathophysiology.

A team of Japanese researchers created a high-quality genome assembly of red perilla, a step toward harnessing the plant’s potentially useful bioactive chemicals — and its medicinal properties.

Osaka Metropolitan University scientists delved into the relationship between gait function and knee extension velocity after total knee arthroplasty and compared the effects of various factors on walking. The results reveal that knee extension velocity, measured while seated, on the operated side was the most important determinant of gait function. These findings are expected to contribute to the development of new rehabilitation programs for efficient gait function improvement.

An Osaka Metropolitan University research team analyzed the regulatory mechanisms of carbohydrate-hydrolyzing enzyme production in Aspergillus aculeatus, a filamentous fungus that produces enzymes with an excellent ability to degrade plant biomass. The team found that UDP-glucose 4-epimerase (Uge5), an enzyme known for its involvement in galactose metabolism, also regulates the expression of degrading enzyme genes in A. aculeatus. This is the very first report of Uge5’s roles in selective gene expression in response to different types of inducing sugars in filamentous fungi.

A research group at Osaka Metropolitan University has succeeded in significantly reducing the measurement time of a glass standard sample by applying Bayesian estimation to X-ray fluorescence analysis. The ability to perform rapid non-contact elemental analysis in a nondestructive manner could lead to the widespread use of this technique in many fields, including the analysis of moving industrial products and waste materials while being carried on conveyor belts.