Japan

Osaka Metropolitan University scientists have developed an AI model that accurately estimates a patient’s age, using chest radiographs of healthy individuals collected from multiple facilities. Furthermore, they found a positive relationship between differences in the AI-estimated and chronological ages and a variety of chronic diseases, such as hypertension, hyperuricemia, and chronic obstructive pulmonary disease. In the future, it is expected that AI biomarkers will be developed to predict life expectancy, estimate the severity of chronic diseases, and forecast surgery-related risks.

Hokkaido University researchers found that tiny nematode worm larvae surf electric fields to hitch rides on passing insects.

Researchers from Osaka University clarified the interactions of the proteins Tejas (Tej), Vasa (Vas), and Spindle-E (Spn-E) in the formation of cellular compartments known as nuage and the processing of PIWI-interacting RNA (piRNA) precursors in Drosophila melanogaster ovaries. piRNAs help prevent the transmission of genetic mutations through reproductive cells, and insight into the dynamics of piRNA formation and processing may contribute to our understanding of the mechanisms underlying reproductive disorders, including infertility.

A team led by researchers at Osaka University and University of California, San Diego has conducted simulations of creating matter solely from collisions of light particles. Their method circumvents what would otherwise be the intensity limitations of modern lasers and can be readily implemented by using presently available technology. This work might help experimentally test long-standing theories such as the Standard Model of particle physics, and possibly the need to revise them.

Rheology of hexagonal close-packed iron determined by high-pressure and high temperature deformation experiments

Researchers at the Institute of Industrial Science, The University of Tokyo use computer simulations of glass-forming particles to discover a new type of exotic ordering impacting the fate of the material.

Researchers from the Institute of Industrial Science, The University of Tokyo, provide physical insights into ion hydration in water-based solutions, which will aid electrolyte design for energy storage technologies.

Researchers at Tohoku University and Massachusetts Institute of Technology (MIT) have unveiled new information about the anomalous dynamics at play when an electric current is applied to a new class of magnetic materials called non-collinear antiferromagnets.

Osaka Metropolitan University scientists tested the antiobesity effects of Mallotus furetianus extract native to Hainan Island, China, using obesity model mice. As a result, body weight and adipose tissue weight of obesity model mice were significantly reduced by the intake of Mallotus furetianus extract. Fatty liver was suppressed and adipocyte size reduction in adipose tissue was observed. Further investigation into the mechanism revealed that fat synthesis is inhibited by suppressing the expression of several transcription factors involved in differentiation into adipocytes.

Tohoku University geophysicist Yuto Katoh led a study into the activity of high energy electrons and clarified the unexpected role of the geomagnetic field surrounding the Earth in protecting.

A research team from the Graduate School of Rehabilitation Science at Osaka Metropolitan University investigated the electrophysiological benefits of working in the presence of others from the perspectives of brain and autonomic nervous system activity. The researchers found that parasympathetic activity—which indicates relaxation—was significantly higher when two individuals were working separately than when one individual was working alone. This suggests that arranging the former condition in occupational therapy for individuals with high levels of tension or anxiety in clinical settings may potentially help alleviate these feelings.

The researchers from Osaka University showed how bone erosion caused by cholesteatoma occurs. This study showed that a subset of cells called osteoclastogenic fibroblasts expresses a protein, activin A, which causes the breakdown of the bones. Because of this discovery, novel medical treatments can be developed as first-line management for cholesteatomas.

Soft metal-organic polymer networks can adsorb selected molecules from gas mixtures by opening pores when the molecules bind.

Osaka Metropolitan University researchers have shown that within the helium-8 nucleus (with two protons and six neutrons), there are two clusters of two neutrons each, existing around the helium-4 core. Furthermore, they demonstrated the shape these clusters take. Nuclei with an imbalance of protons and neutrons, such as in helium-8, do not naturally exist on Earth but are believed to be abundantly generated in cosmic environments like the interiors of stars through the process of nucleosynthesis. This study’s findings provide new insights into the still largely unknown binding forms of neutrons and deepen our understanding of the origins of the elements that surround us.

Molecules that act as connected wheels can hold long molecular chains together to modify the properties of soft polymers.

Researchers from Osaka University found that patients with persistently high levels of urinary albumin excretion in the long term are at high risk of new-onset heart failure. Preventive treatment associated with the lowering of urinary albumin excretion levels in these patients could reduce the risk of later heart failure or mortality.

Researchers from Osaka University have demonstrated a proof-of-concept for identifying single nucleotides by using quantum computing. Molecular rotation patterns—and the corresponding variations in conductance—within the nanoscale gap between two electrodes enabled the development of a quantum gate for the nucleotide adenosine monophosphate. Developing quantum gates for the other three nucleotides, and incorporating this technology into DNA sequencing workflows, could revolutionize genome analysis.

succeeded in preparing atactic C1 polymers with a high melting point of up to 130 ℃ by utilizing a hydrogen-bonding interaction among amide-linkages incorporated into the polymer side-chains.

Elucidation of global anti-aromaticity (aromaticity) in homoHPHAC+ (homoHPHAC3+) with electron-accepting to electron-donating substituents

What does healthy aging look like? For answers, Hiroshima University environmental health expert Dr. Saori Kashima taps into a new science dedicated to Earth’s longevity.

Researchers from Osaka University use quasi-elastic neutron scattering to get a close look at the behavior of water molecules in a semiclathrate hydrate crystal. They found that the molecules showed fast reorientation with an activation energy similar to that of cleaving a hydrogen bound. This rapid relaxation time in the solid electrolyte is expected to lead to efficient, cost-effective, and safe applications for semiclathrate hydrates in batteries and thermal storage materials.

An exquisitely preserved fossil forest from Japan provides missing links and helps reconstruct a whole Eurasia plant from the late Miocene epoch.

Researchers from the Institute of Industrial Science, The University of Tokyo, provide physical insights into porous soft materials, which will facilitate the design of many energy, medical, and other technologies.

A joint research group at Osaka Metropolitan University conducted a survey on prevalence of obesity and factors associated with low obesity among 423 adolescents between the ages of 14 and 19 living in Harare, Zimbabwe. The results revealed that 15.8% were obese or overweight. The study also revealed that 27.1% of the participants had low obesity awareness, which was significantly related to parents/guardians' lack of formal education and insufficient knowledge about eating habits.

RNases have been proposed as a treatment against systemic autoimmune diseases. Researchers from Osaka University showed that RNases have a dual action. In some cases, RNases are detrimental and stimulate the immune response by promoting the binding of antibodies to their targets. These findings will improve the understanding and treatment of systemic autoimmune disorders.

Researchers from Osaka University have developed a fluorescent sensor that may be useful for understanding how cells recognize themselves versus other cells when making connections in the brain. Specifically, their sensor can be used to visualize not only connections between cells, but also the disassociation of these interactions. Because neuronal self-connectivity has been implicated in brain disorders like epilepsy and autism, a better understanding of this process may result in improved therapies.

Researchers from Northwestern University and recently joining the Institute for Industrial Science, The University of Tokyo develop a high-throughput approach to evaluate protein folding stability in thousands of proteins .

A research team has discovered an astounding array of unexplored protein folds. This research will expand our understanding of the depth of the protein universe and the possibilities for de novo design of functional proteins.

The physiological mechanisms underlying severe burns are not well understood. Researchers at Osaka University used mass spectrometry to identify key blood proteins associated with burn mortality. Ultimately, three proteins (HBA1, TTR, SERPINF2) were very highly correlated with morality rates. Further research into these proteins and their pathways may lead to better drugs to treat people with life-threatening burns.

The entire biosynthetic pathway of actinopyridazone has been unveiled, revealing that an unprecedented carrier protein-mediated ring-forming step is key to its synthesis.