Japan

Researchers from The University of Osaka have found that a specific signaling pathway, the integrin αV–YAP–CTGF axis in liver sinusoidal endothelial cells, may be associated with the development of liver fibrosis, portal hypertension, and liver cancer in patients with chronic liver congestion. These findings have important implications for the development of therapies aimed at preventing more severe forms of liver disease.

Study of 56 japonica rice varieties finds black and green rice to be healthier choices

An Osaka Metropolitan University-led research team used hourly precipitation data from 1981 to 2020 and spatial modeling to predict extreme precipitation events for the next 100 years in Japan.

Biochemical and structural biological analysis of a hypothetical gene (protein) within a gene cluster related to metabolic pathway of L-threonate, a four-carbon sugar acid, revealed it’s enzyme function as a L-threonate 3-dehydrogenase and physiological role for metabolic diversity. Although the existence of this enzyme itself was reported in the same academic journal in 1964, the molecular identity of which has remained unknown for over 60 years.

Researchers from The University of Osaka have developed a mouse model for achondroplasia. The model identified the importance of a signaling molecule called FGFR3 and a pathway called CREB in regulating bone growth. This pathway is also at least partially responsible for the pathology associated with achondroplasia and impaired bone growth. Their findings advance our understanding of the process of bone growth and provide novel therapeutic targets for achondroplasia.

Glutamine transporter inhibition has been found to suppress cell growth

We all want cheap, long-lasting, green, and efficient energy. Researchers are helping to make this dream a reality with a new distortion-resistant material that greatly improves these aspects of a battery’s cathode.

More thorough testing of methane and ethane emissions in Osaka, Japan, identified numerous natural gas-related large methane sources that were mostly overlooked in current predictions. These sources may be useful future targets for mitigating emissions.

The University of Osaka’s Center for Quantum Information and Quantum Biology (QIQB) is a premier research institute in Japan, distinguished by its extensive global network of leading institutions worldwide.

Cleaner fish interacted with a mirror in their tank in a way that suggests ‘contingency testing’ intelligence, a higher form of smarts typically found in mammals. This finding coupled with faster self-recognition than previously thought, expands our image of intelligence in these social fish.

Researchers at The University of Osaka have developed a method to reproducibly form subnanometer pores within a solid-state nanopore. A voltage-driven chemical reaction produces a precipitate that fills and closes the nanopore, while dissolution reopens conductive pathways. This process forms many subnanometer-sized pores, whose effective size can be tuned by changing reactant composition and pH. These ultrasmall pores mimic biological ion channels and enable studies of ion transport in confined spaces.

Researchers at The University of Osaka have created highly transparent wood without plastic additives and revealed that its clarity depends on structural direction. Alkali treatment softens cellulose-based cell walls, allowing internal cavities to collapse during drying and reduce light scattering. Tangential sections become more transparent than radial ones due to anisotropic swelling and densification. The findings offer new design principles for sustainable transparent materials in buildings and advanced devices.

Rehabilitation on weekends and public holidays may improve post-surgery recovery for hip fractures

DNA - the blueprint of life – can also act as a reaction vessel that guides chemical reactions. This is possible using interstrand crosslinking technology developed by researchers at Tohoku University.

An international collaborative research team, including researchers from the Faculty of Frontier Engineering at Kanazawa University, has for the first time elucidated sex differences in motor unit firing patterns in patients with Parkinson's disease. Utilizing high-density surface electromyography (HD-SEMG), their detailed analysis of motor unit activity revealed that female patients exhibited significantly greater asymmetry in motor unit discharge rates and lower persistent inward currents (PICs) compared to males. These findings suggest that neurodegeneration may be more asymmetrical in females, even when presenting with similar motor symptoms. This study indicates that motor unit behavior can serve as a sensitive evaluation tool to highlight differences in disease presentation between sexes, potentially leading to the development of personalized treatment strategies that consider sex-specific factors in the future.

Research from The University of Osaka highlights a new model of a gyroscopic wave energy converter. The device was shown to be capable of absorbing up to half of incoming wave energy across a wide range of frequencies, meaning it could achieve the theoretical maximum efficiency. These results provide important design insights for more efficient and adaptable wave energy technologies.

A study finds that shelterbelts, trees planted as windbreaks, in Japan’s wet farmlands boost edge-dwelling bird population but cut grassland species by about 74%, with numbers rebounding roughly a kilometer away, revealing an overlooked conservation trade-off.

Researchers from the Institute of Industrial Science, The University of Tokyo track the global circulation of water molecules in time and space using isotope ensemble modeling, enabling better prediction of changing hydrological patterns and weather extremes

Researchers at Tohoku University discovered an intranodal lympho-venous shunt (a sort of bypass route) that could help us unravel the complicated, intertwined network of our body’s lymphatic system.

The approach uses 3D printing to produce WC–Co cemented carbides—ultra-hard materials used in cutting and construction tools—while reducing the waste and cost of conventional manufacturing.

Carbon-based π-electron compounds are usually a first pick for their catalyst potential, but researchers have developed a stable silicon version – a feat that has been a major challenge until now.

This research study assessing 23,000 mother-child pairs found that higher maternal depression around the period of birth may impair mother-infant bonding and increases the risk of autism in their daughters.

Study highlights the uniqueness of individual brain functional connectomes as a promising approach to identify biomarkers for major depressive disorder.

Researchers from the Institute of Industrial Science, The University of Tokyo have used 3D-printing technology to improve the viral titer of microneedle array patches, resulting in effective immunogenicity and protection against infection in mice

A comprehensive analysis of supersulfide production in fermented soybeans

Researchers at Tohoku University have developed a much more efficient way to produce ethylamine - a crucial component for dyes, pharmaceuticals, and more. It all starts with a catalyst.

We may be closer to unravelling the mystery of how the dry, arid Mars used to be covered in water from new research that focuses on an unexpected event (a powerful dust storm) at an unexpected time (Northern Hemisphere summer).

When cultivated tobacco is crossed with a wild relative it erases lethal genes, allowing normally fatal hybrids to survive.

Take a dive into the streamlined workflow of DIVE (Descriptive Interpretation of Visual Expression)! DIVE combines multiple AI agents to extract images from about 4,000 scientific publications to propose new materials – all within minutes.

A potential breakthrough for jet lag and shift work-related sleep disorders. A Japanese research team has discovered a new compound that can advance the body’s internal clock—offering hope for faster recovery from jet lag and better adaptation to night-shift work. The compound, called Mic-628, specifically activates the transcription of a clock gene named Period1 (Per1). When given orally to mice, it advanced their body clocks and activity rhythms, regardless of dosing time. The findings suggest a new approach to controlling circadian rhythms through drug action rather than light exposure.