Associate Professor Tsuyoshi Mita

Tsuyoshi Mita is a specially appointed associate professor at the Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University, Japan.

Research Theme
Synthetic organic chemistry (development of new chemical reactions, catalyst design)

Development of new chemical reactions, Carbon dioxide fixation, Amino acids

Education and Working Experiences

1996.4-2000.3: Chemistry Department, Keio University, Supervisor: Prof. Tohru Yamada (BSc) 2000.4-2002.3: Graduate School of Science and Technology, Keio University Supervisor: Prof. Tohru Yamada (MSc)
2002.4-2004.3: Ajinomoto Co., INC. (Process Research & Development, Pharmaceutical Research Laboratories in Pharmaceutical Company, Kawasaki, Japan) 
2004.4-2007.3: Graduate School of Pharmaceutical Sciences, The University of Tokyo Supervisor: Prof. Masakatsu Shibasaki (PhD) 
2007.4-2009.3: Department of Chemistry & Chemical Biology, Harvard University Supervisor: Prof. Eric N. Jacobsen (Postdoctoral Fellow (JSPS Fellowship_SPD)) 
2009.4-2019.3: Faculty of Pharmaceutical Sciences, Hokkaido University (Assistant Professor in the Yoshihiro Sato’s group) 
2019.4-present: Institute for Chemical Reaction Design and Discovery (WPI-ICReDD) (Specially Appointed Associate Professor) 
2019.10-present: JST, ERATO “Artificial Intelligence in Chemical Reaction Design and Discovery” (A group leader in synthetic organic chemistry)

Representative Research Achievements

  • Mita, T.*; Harabuchi, Y.; Maeda, S.* “Discovery of a Synthesis Method for a Difluoroglycine Derivative Based on a Path Generated by Quantum Chemical Calculations” Chem. Sci. 2020, 11. DOI: 10.1039/D0SC02089C.
  • Mita, T.*; Uchiyama, M.; Sato, Y.* “Catalytic Intramolecular Coupling of Ketoalkenes by Allylic C(sp3)–H Bond Cleavage: Synthesis of Five- and Six-Membered Carbocyclic Compounds” Adv. Synth. Catal. 2020, 362 (6), 1275-1280. DOI: 10.1002/adsc.201901533
  • Mita, T.*; Ishii, S.; Higuchi, Y.; Sato, Y.* “Pd-Catalyzed Dearomative Carboxylation of Indolylmethanol Derivatives” Org. Lett. 201820 (23), 7603-7606. DOI: 10.1021/acs.orglett.8b03337
  • Michigami, K.; Mita, T.*; Sato, Y.* “Cobalt-Catalyzed Allylic C(sp3)-H Carboxylation with CO2” J. Am. Chem. Soc. 2017139 (17), 6094-6097. DOI: 10.1021/jacs.7b02775
  • Mita, T.*; Sugawara, M.; Sato, Y.* “One-Pot Synthesis of α-Amino Acids through Carboxylation of Ammonium Ylides with CO2 Followed by Alkyl Migration” J. Org. Chem. 201681 (12), 5236-5243. DOI: 10.1021/acs.joc.6b00837
  • Mita, T.*; Higuchi, Y.; Sato, Y.* “Highly Regioselective Palladium-Catalyzed Carboxylation of Allylic Alcohols with CO2” Chem. Eur. J. 201521 (46), 16391-16394. DOI: 10.1002/chem.201503359
  • Mita, T.*; Sugawara, M.; Saito, K.; Sato, Y.* “Catalytic Enantioselective Silylation of N-Sulfonylimines: Asymmetric Synthesis of α-Amino Acids from CO2 via Stereospecific Carboxylation of α-Amino Silanes” Org. Lett. 201416 (11), 3028-3031. DOI: 10.1021/ol501143c
  • Mita, T.*; Ikeda, Y.; Michigami, K.; Sato, Y.* “Iridium-Catalyzed Triple C(sp3)-H Borylations: Construction of Triborylated Sp3-Carbon Centers” Chem. Commun. 201349 (49), 5601-5603. DOI: 10.1039/C3CC42675K
  • Mita, T.*; Chen, J.; Sugawara, M.; Sato, Y.* “One-Pot Synthesis of α-Amino Acids from Imines through CO2Incorporation: An Alternative Method for Strecker Synthesis” Angew. Chem. Int. Ed. 2011, 50 (6), 1393-1396. DOI: 10.1002/anie.201006422
Specially Appointed Associate Professor
Institute for Chemical Reaction Design and Discovery (WPI-ICReDD)
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