Associate Professor Tsuyoshi Mita

Tsuyoshi Mita is a specially appointed associate professor at the Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University, Japan.

Research Theme
Synthetic organic chemistry (development of new chemical reactions, catalyst design)

Keyword
Development of new chemical reactions, Carbon dioxide fixation, Amino acids

Education and Working Experiences

1996.4-2000.3: Chemistry Department, Keio University, Supervisor: Prof. Tohru Yamada (BSc) 2000.4-2002.3: Graduate School of Science and Technology, Keio University Supervisor: Prof. Tohru Yamada (MSc)
2002.4-2004.3: Ajinomoto Co., INC. (Process Research & Development, Pharmaceutical Research Laboratories in Pharmaceutical Company, Kawasaki, Japan) 
2004.4-2007.3: Graduate School of Pharmaceutical Sciences, The University of Tokyo Supervisor: Prof. Masakatsu Shibasaki (PhD) 
2007.4-2009.3: Department of Chemistry & Chemical Biology, Harvard University Supervisor: Prof. Eric N. Jacobsen (Postdoctoral Fellow (JSPS Fellowship_SPD)) 
2009.4-2019.3: Faculty of Pharmaceutical Sciences, Hokkaido University (Assistant Professor in the Yoshihiro Sato’s group) 
2019.4-present: Institute for Chemical Reaction Design and Discovery (WPI-ICReDD) (Specially Appointed Associate Professor) 
2019.10-present: JST, ERATO “Artificial Intelligence in Chemical Reaction Design and Discovery” (A group leader in synthetic organic chemistry)

Representative Research Achievements

  • Mita, T.*; Harabuchi, Y.; Maeda, S.* “Discovery of a Synthesis Method for a Difluoroglycine Derivative Based on a Path Generated by Quantum Chemical Calculations” Chem. Sci. 2020, 11. DOI: 10.1039/D0SC02089C.
  • Mita, T.*; Uchiyama, M.; Sato, Y.* “Catalytic Intramolecular Coupling of Ketoalkenes by Allylic C(sp3)–H Bond Cleavage: Synthesis of Five- and Six-Membered Carbocyclic Compounds” Adv. Synth. Catal. 2020, 362 (6), 1275-1280. DOI: 10.1002/adsc.201901533
  • Mita, T.*; Ishii, S.; Higuchi, Y.; Sato, Y.* “Pd-Catalyzed Dearomative Carboxylation of Indolylmethanol Derivatives” Org. Lett. 201820 (23), 7603-7606. DOI: 10.1021/acs.orglett.8b03337
  • Michigami, K.; Mita, T.*; Sato, Y.* “Cobalt-Catalyzed Allylic C(sp3)-H Carboxylation with CO2” J. Am. Chem. Soc. 2017139 (17), 6094-6097. DOI: 10.1021/jacs.7b02775
  • Mita, T.*; Sugawara, M.; Sato, Y.* “One-Pot Synthesis of α-Amino Acids through Carboxylation of Ammonium Ylides with CO2 Followed by Alkyl Migration” J. Org. Chem. 201681 (12), 5236-5243. DOI: 10.1021/acs.joc.6b00837
  • Mita, T.*; Higuchi, Y.; Sato, Y.* “Highly Regioselective Palladium-Catalyzed Carboxylation of Allylic Alcohols with CO2” Chem. Eur. J. 201521 (46), 16391-16394. DOI: 10.1002/chem.201503359
  • Mita, T.*; Sugawara, M.; Saito, K.; Sato, Y.* “Catalytic Enantioselective Silylation of N-Sulfonylimines: Asymmetric Synthesis of α-Amino Acids from CO2 via Stereospecific Carboxylation of α-Amino Silanes” Org. Lett. 201416 (11), 3028-3031. DOI: 10.1021/ol501143c
  • Mita, T.*; Ikeda, Y.; Michigami, K.; Sato, Y.* “Iridium-Catalyzed Triple C(sp3)-H Borylations: Construction of Triborylated Sp3-Carbon Centers” Chem. Commun. 201349 (49), 5601-5603. DOI: 10.1039/C3CC42675K
  • Mita, T.*; Chen, J.; Sugawara, M.; Sato, Y.* “One-Pot Synthesis of α-Amino Acids from Imines through CO2Incorporation: An Alternative Method for Strecker Synthesis” Angew. Chem. Int. Ed. 2011, 50 (6), 1393-1396. DOI: 10.1002/anie.201006422
Role: 
Specially Appointed Associate Professor
Department: 
Institute for Chemical Reaction Design and Discovery (WPI-ICReDD)
Languages: 
English
Japanese
Academic discipline: 
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