Biology

News

Principle of Nanofluidic Aptamer Nanoarray (NANa)
23 Jun 2023
An international team led by Professor Yan Xu from Osaka Metropolitan University has developed a groundbreaking nanofluidic device, named NANa, capable of stochastically capturing and digitally detecting individual proteins at cellular concentrations. This tool, vital for precision medicine, is designed to handle tiny volumes equivalent to a single cell's contents and can identify single biomolecules even in high-concentration environments. The team plans to conduct further demonstrations using actual cell samples and explore the integration of this tool with AI and biological big data. This research could potentially revolutionize personalized disease prevention and treatment.
The 39 dogs in the study were divided into three groups based on treatment strategies (Tatsuya Deguchi, Naoya Maekawa, et al. Cancers. June 1, 2023).
23 Jun 2023
A combination of radiotherapy followed by immunotherapy is a promising strategy for the treatment of oral malignant melanomas in dogs.
Asia Research News Editor's Choice header
19 Jun 2023
A key protein for sperm maturation identified, Understanding gel formation, Urine test predicts organ diseases, A laser drills holes in a graphene film. Plus in our blog - The frogs of Borneo: more than just a race. Read all in the latest Editor's Choice.
19 Jun 2023
Researchers from Osaka University found that the binding of two proteins—Polydom and Tie1—is essential for lymphatic cell migration in the remodeling of lymphatic vessels, which transport molecules around the body. A better understanding of the development and remodeling of the lymphatic system will lead to better therapeutic options for diseases such as lymphedema, which is common in cancer patients and currently has no cure.
The transfer of pathogenic genes between not only same bacterial species but also different species
15 Jun 2023
A joint research group led by Osaka Metropolitan University has clarified how pathogenic genes in some Providencia spp., which have gained attention as causative agents of food poisoning as well as enterohemorrhagic Escherichia coli. O157 and Salmonella, are transferred within bacterial cells. Their findings are expected to provide new insights into the identification of infection routes of Providencia spp. and the establishment of preventive methods for food poisoning.
08 Jun 2023
A team led by researchers from Osaka University elucidated a molecular mechanism that is crucial for separating genetic material into daughter cells during cell division. A protein called CENP-C is part of a complex called the kinetochore, which supports the movement of chromosomes. Two portions of CENP-C, the CCAN-binding domain and Cupin domain, are needed for CENP-C to function. The Cupin domain repeats itself through oligomerization, which is essential for proper CENP-C function.
08 Jun 2023
A stem cell therapy treatment developed by Duke-NUS Medical School researchers for heart failure has shown promising results in preclinical trials. These cells, when transplanted into an injured heart, are able to repair damaged tissue and improve heart function.
Letters in Applied Microbiology
07 Jun 2023
The peer-reviewed journal Letters in Applied Microbiology is recruiting its first intake of Junior Editors as part of its new drive to nurture early careers talent.
IMAGE
06 Jun 2023
Ultrafast fluorescent imaging technology brings the molecular dynamics of living cells into clear view.
05 Jun 2023
Researchers from Osaka University developed an in vivo CRISPR screen to analyze factors affecting Toxoplasma gondii fitness in healthy and immunodeficient mice. Mice were infected with Toxoplasma containing CRISPR libraries that targeted specific genes; genetic sequencing was then performed to identify which genes are important to fitness. The genetic screen clarified the contributions of host genetics and parasite genetics and can contribute to the development of strategies for toxoplasmosis treatment and prevention.
01 Jun 2023
Tests could soon identify patients who will respond well to the available treatment for chronic myeloid leukaemia and those who will be resistant to it—which could improve their chances of survival.
01 Jun 2023
Scientists at Tohoku University have discovered a novel approach that improves the efficacy of immune checkpoint blockade - a novel form of cancer treatment utilizing immune checkpoint inhibitors - and minimizes the associated side effects. Using immune checkpoint blockades to target tumor-positive lymph nodes, they generated a robust anti-tumor response against both local and systemic metastases.
29 May 2023
Zinc is essential for our health. Our bodies must constantly regulate its zinc levels, otherwise fatal diseases such as cancers, growth failures, ad immunodeficiency can occur. Now, a research group has unearthed how zinc transporter complexes regulate zinc ion concentrations in different areas of the Golgi apparatus.
26 May 2023
A research team, led by researchers from Osaka University, performed genetic screening of fission yeast lacking DNA repair gene Rad51 to identify genes that play a role in gross chromosomal rearrangement (GCR), a type of mutation that occurs at the centromere. Cells lacking Srr1 or Skb1 exhibited reduced GCR, indicating that these genes are important to the occurrence of GCR. These findings advance our understanding of the mechanisms underlying centromeric GCR.
Influence of Bacillus subtilis var. natto intake
25 May 2023
Eating fermented foods might be the secret to a healthy and long-lived society
Asia Research News Editors Choice
19 May 2023
Mushrooms 🍄get chattier after rainfall 🌧️, Two-organ chip answers fatty liver questions, History maps 🗺️vs future simulations, Restoring vision in blindness. Plus in our blog: Myanmar: Through eyes of leadership. Read all in the latest Editor's Choice.
18 May 2023
It’s not unusual for many of us to reach for a cup of coffee or cup of tea whilst focusing our attention on a screen. Scientists have long pondered whether our hand movements influence our spotlight attention. And now a group of researchers from Tohoku University have discovered that our spotlight attention and the attention paid to our moving hands operates via independent mechanisms.
17 May 2023
A research group led by Osaka University has found that plant cells may be able to detect mechanical forces to determine their own position within the leaf—whether they are on the surface or in the inner tissues—and therefore differentiate into appropriate cell types after damage. These findings reveal how plants regenerate the correct type of tissues when damaged, and may improve our understanding of the mechanisms underlying the high regeneration potential of plants.
15 May 2023
Researchers at Kanazawa University report in Nano Letters how high-speed atomic force microscopy leads to insights into processes relevant to Alzheimer’s disease. Moreover, the technique is shown to be an excellent tool for studying the effect of drugs against the disease.
15 May 2023
Researchers at Kanazawa University report in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) high-speed atomic force microscopy experiments that show how ligands associated with stimulating and suppressing activation of the TRPV1 protein increase and decrease the molecule’s structural variations. The observations provide insights into how these heat- and chilli-sensing proteins function.
12 May 2023
Specially coated surfaces help scientists investigate what happens when cell clusters are turned upside down.
11 May 2023
A protein that helps bats survive viral diseases might offer lessons for developing new anti-inflammatory treatments.
11 May 2023
Researchers from Osaka University identified a new protein, R-spondin 3 (RSPO3), that has beneficial effects after ischemic stroke in mice. Specifically, RSPO3 activates the protein LGR4 to trigger a cascade of cellular reactions that decreases inflammation and stimulates the growth of neuronal extensions. Moreover, administrating RSPO3 to mice one day after stroke improved recovery of sensory and motor functions. These findings provide a new target for developing treatments to improve recovery after ischemic stroke.
11 May 2023
DGIST and New Life Group launched a research project on "Functional beauty and health products using the latest nanotechnology."
11 May 2023
- In a groundbreaking study, Professor Yea’s DGIST research team verified the effectiveness of the anti-GFRAL human antibodies in improving chemotherapy-induced cancer cachexia - The team presents a candidate antibody for managing cancer cachexia, a condition without an approved and effective therapy worldwide
Arbuscular mycorrhizal (AM) fungi in the Glomeromycotina colonize plant roots (left, micrograph) and deliver water and nutrients from soil (right). (Tatsuhiro Ezawa).
11 May 2023
A new group of mitochondrial viruses confined to the arbuscular mycorrhizal fungi Glomeromycotina may represent an ancestral lineage of mitoviruses.
11 May 2023
- The DGIST team of Professor Minseok Kim is jointly developing a platform that can analyze rare cells without loss with CTCELLS, Inc. - A high cell preservation rate and reproducibility have been achieved as well as accurate immunocytochemistry technology implementation. - Research results have been published in ACS Applied Materials & Interfaces.
11 May 2023
- Prof. Jung Ho Hyun’s research team at DGIST has developed a tool to verify the causal relationship between specific neurons and circuits and behavior - This will provide new information for the development of treatments using light for neurological ad psychological disorders
11 May 2023
Researchers from Osaka University identified a new protein, NICOL, and described its crucial role in the maturation of sperm, which itself is necessary for male fertility. Mice who lacked this protein were sterile. Such a discovery may have implications for the development of male contraceptives.
Damage to the liver induced by acetaminophen (dotted blue outlines) is almost completely mitigated by CoQ10-MITO-Porter (right), compared to the effect of phosphate buffered saline (left) and direct administration of CoQ10(center). (Mitsue Hibino, et al. Scientific Reports. May 10, 2023).
10 May 2023
A new drug delivery system delivers an antioxidant directly to mitochondria in the liver, mitigating the effects of oxidative stress.

Events

Sorry, nothing coming up for this discipline

Researchers

Sorry, nothing coming up for this discipline

Giants in history

Sorry, nothing coming up for this discipline