Biology Immunology

News

A C57BL/6 mouse used in the study (Photo: Haruka Wada)
14 Nov 2023
Cancer stem cells cause the aging of macrophages in mice with healthy immune systems, creating conditions for the formation of tumors.
pregnant woman
13 Nov 2023
New study finds prior dengue antibodies substantially raise risk of microcephaly, foetal defects with Zika infection.
29 Sep 2023
The authors discovered a shorter isoform of Rubicon called RUBCN100, which enhances autophagy in B cells.
29 Sep 2023
The authors identified a structure in the circadian mRNA Period2 that affects the sleep-wake cycle. The results indicate how translation and post-transcriptional processes influence the body’s internal clock and its impact on sleep patterns.
03 Aug 2023
The researchers from Osaka University showed how bone erosion caused by cholesteatoma occurs. This study showed that a subset of cells called osteoclastogenic fibroblasts expresses a protein, activin A, which causes the breakdown of the bones. Because of this discovery, novel medical treatments can be developed as first-line management for cholesteatomas.
18 Jul 2023
RNases have been proposed as a treatment against systemic autoimmune diseases. Researchers from Osaka University showed that RNases have a dual action. In some cases, RNases are detrimental and stimulate the immune response by promoting the binding of antibodies to their targets. These findings will improve the understanding and treatment of systemic autoimmune disorders.
The 39 dogs in the study were divided into three groups based on treatment strategies (Tatsuya Deguchi, Naoya Maekawa, et al. Cancers. June 1, 2023).
23 Jun 2023
A combination of radiotherapy followed by immunotherapy is a promising strategy for the treatment of oral malignant melanomas in dogs.
Asia Research News monthly Editors Choice
10 Apr 2023
AI finds the first stars ✨were not alone, Auto-switch for large electronic devices, A metabolite against autoimmune diseases, & Converting fruit waste 🍊🍉into solar stills. Plus in our blog: A career worth doing, a life worth living. Read all in the latest Editor's Choice.
05 Apr 2023
Researchers from Osaka University found that the COMMD3/8 complex is implicated in the progression of the autoimmune response in a mouse model of rheumatoid arthritis. They identified celastrol, the active compound of a medicinal herb, as an inhibitor of the COMMD3/8 complex. Celastrol blocked the progression of rheumatoid arthritis. Thus, celastrol is a potential lead for developing treatments against rheumatoid arthritis.
23 Mar 2023
Researchers from Osaka University identified a subset of fibroblastic reticular cells (FRCs) that simultaneously express two proteins, Aldh1a2 and Tie2, making them unique to areas of the omentum called milky spots. Genetic depletion of these cells caused structural disruption of milky spots. The FRCs were critical to the abdominal immune system as they regulated CXCL12 levels, a molecule necessary for lymphocyte recruitment from blood circulation. These insights can help develop novel treatments for intra-abdominal infections.
In mice models with adoptive transfer experimental autoimmune encephalomyelitis, treatment with itaconate (right) greatly ameliorates the effects of the disease, compared to untreated mice (Kuniyuki Aso, et al. Nature Communications. February 27, 2023).
15 Mar 2023
Researchers have revealed the modulatory effect of the anti-inflammatory metabolite itaconate on T helper and T regulatory cells, which may lead to new therapeutic approaches to treating some autoimmune diseases.
Covid-19 vaccines and syringe
07 Mar 2023
Researchers in Sarawak, Malaysia, measured the immunity responses of people who received different COVID-19 vaccines.
13 Feb 2023
Researchers from Osaka University have shown sex-specific differences in the immune response to COVID-19 infection. By identifying and analyzing the immune cell population in COVID-19 patients, they showed that infection results in a reduced ratio of circulating follicular T regulatory (cTfr) cells to a network of antibody-producing proteins, correlated with dysregulated antibody production. This cTfr cell reduction is more significant in males, providing cellular evidence for the observed association between increased risk and male sex.
12 Feb 2023
In hepatic steatosis, hepatocytes "die," resulting in liver damage. Severe steatosis increases hepatocellular deaths, thus aggravating liver damage. The mechanism is unclear. Using mice, we show that mild steatosis causes apoptosis whereas severe steatosis predominantly causes necroptosis leading to cell rupture. This induces strong inflammation and new cell death, producing further liver damage. We reveal the transcription factor ATF3 to be involved in this process. Our results are expected to contribute to therapeutic method development.
15 Dec 2022
Understanding how bats tolerate viral infections, Material separates water from...water, The virtual sense of touch polished to next level and COVID-19 negatively impacted early-careers and female researchers. Read all in the December's Editor's Choice.
14 Dec 2022
Researchers led by Osaka University generated a time-stamping method to trace the development and survival of plasma cells in the bone marrow and spleen. Using a mouse model in which plasma cells were fluorescently labeled in an inducible manner, they found that plasma cells were continuously replenished by new cells, a small portion of which differentiated into long-lived plasma cells (LLPCs). These findings may aid in the development of new vaccines that efficiently induce LLPCs.
24 Nov 2022
Understanding how bats tolerate viral infections without developing symptoms may lead to better ways of combatting human disease.
21 Nov 2022
Intestinal bacteria composition is crucial to driving the recovery of neutrophils counts in the blood of mice following treatments such as stem cell transplants or chemotherapy.
14 Nov 2022
In a study recently published in the Journal of Extracellular Vesicles, researchers from Kanazawa University use high-speed microscopy to capture the dynamics of nanosized sacs released from cells.
20 Jul 2022
Researchers at the Institute of Industrial Science at The University of Tokyo introduce a machine learning method to help predict past infection from receptor sequences of immune T-cells even when little data is available, which may help improve human health and our understanding of adaptive immunity
05 Jul 2022
Innate immunity is activated when the pattern recognition receptors (PRRs) recognize pathogen-associated molecular patterns (PAMPs). We show that a liver-derived secretory protein LECT2, a hepatokine, binds to the HGF receptor MET, a proto-oncogene product, to suppress the proliferation signal of MET. LECT2 activates retinoic acid-inducible gene-I, enhancing antiviral and innate immune responses through MET. Thus, LECT2 is an anti-proliferative and immunoregulatory factor that could be a therapeutic target for viral infections and cancer.
21 Jan 2022
A booster dose of the Pfizer–BioNTech vaccine (BNT162b2) against SARS-CoV-2 after an initial two doses of either the CoronaVac inactivated virus vaccine or Pfizer–BioNTech mRNA vaccine is shown to provide protection against the Omicron variant, in a pair of papers published in Nature Medicine.
23 Dec 2021
By searching for the protein transglutaminase 1 (TGM1) among patients with various autoimmune skin diseases, researchers have successfully identified a separate disease that can be linked to autoimmunity against TGM1. This backward method demonstrates a new way of identifying autoantigens as markers for various diseases. By letting autoantigens point to the disease, diagnosis and treatment can be facilitated, according to the study now published in PNAS.
The expression of the immune response gene ​​NLRC5 (red purple) is suppressed in SARS-CoV-2 (green) infected cells (Photo: Ji-Seung Yoo, Koichi Kobayashi).
07 Dec 2021
Scientists at Hokkaido University and Texas A&M University have identified a key mechanism used by the SARS-CoV-2 virus to evade host immune systems.
25 Oct 2021
Researchers have revealed in an animal model that ImmuBalance, a fermented soybean product, is effective in suppressing airway inflammation caused by asthma. Results showed a decreased presence of eosinophils in bronchoalveolar lavage fluid, a decrease in mucus production in the bronchial epithelium, and a suppression of proteins that induce eosinophilic inflammation.
IMAGE
13 Sep 2021
iCeMS scientists and colleagues have designed a molecular code that powers up cancer-fighting immune cells.
11 Aug 2021
Researchers discover a link between an increase in protein Ba of the complement immune system and the eventual development of thrombotic microangiopathy in patients who have received an allogeneic hematopoietic stem cell transplantation.
The fluorescence polarization immunoassay developed to detect and quantify antibodies against SARS-CoV-2
15 Jul 2021
Scientists have developed a rapid, highly accurate test to detect antibodies against the spike protein of SARS-CoV-2 in human serum, opening a new avenue for understanding the full extent of the pandemic and evaluating the effectiveness of vaccines.
21 May 2021
Scientists from Hokkaido University have discovered a novel defensive response to SARS-CoV-2 that involves the viral pattern recognition receptor RIG-I. Upregulating expression of this protein could strengthen the immune response in COPD patients.
30 Oct 2020
Maternal antibodies primed to react to specific allergens can cross the placenta, passing on transiently allergic reactions to offspring, according to new preclinical research from a collaborative study by the Agency for Science, Technology and Research, KK Women’s and Children’s Hospital, and Duke-NUS Medical School in Singapore. The finding hints at why infants exhibit allergies so early in life and suggests possible targets for intervention.

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Researchers

Dr Sarkar is a senior research fellow at the Murdoch Children's Research Institute in Melbourne, Australia. She is actively engaged in collaborating with academic and industry stakeholders and leads multiple projects for the development of novel therapeutics/vaccines to tackle antimicrobial resistance.
Young scientist from Kulgam,  Kashmir.
Dr Ashfaq Ahmad Shah 'اشفاک ' born on 6 June 1992, from south Kashmir, Doderkoot ددیرکوٹ Kulgam, Jammu and Kashmir, India is the infection immunity doctoral researcher at the Graphic Era (Deemed to be University), Dehradun, UK, India. Dr Shah is pursuing novel dimensions of infection immunity pertaining to the correlation and impact of phyto-immune components termed phytoalexins and phytoanticipins on the benign immune system of human beings. This parameter of immunology is termed phytoalexin-immunomodulation scrutiny. His area of interest lies in Preclinical and clinical studies, i.e. vaccine adjuvant development, development of anti-inflammatory and antimicrobial compounds, evaluation of antibiotic resistance, study of Immuno-modulatory activities, disease model studies, protease isolation against specific protein antigens, and the discipline of Kalology including tyrosinase inhibition, PPO inhibition, skin whitening agents, kerato-peeling etc. Dr Ashfaq is a Doctoral Researcher, Reviewer and Editorial member of several journals and books. He is having several publications in journals of national and international repute. So far he has published more than thirty scopus infection/immunology/pharmacology scientific papers, including Fifteen international book chapters and two international books. Mr Shah received the Young scientist award in August 2023 for his groundbreaking academic performance in the field of infection immunity. Mr Shah has also been an editor of Wikipedia pages in medical science since 2015 with more than 1000 edits in medical topics available to medical literature worldwide.
Cheng Siang Tan
Dr. Cheng-Siang Tan is an Associate Professor at the Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak (UNIMAS). He is an expert in infectious and emerging diseases and biosafety and biorisk management.
Matthew Tay
Dr. Tay has researched antibodies and diseases like malaria and SARS-CoV-2 at A*STAR. His focus is on discovering methods for developing antibodies that can be used in therapies against multidrug-resistant pathogens.
Amit Singhal
Dr. Singhal serves as senior principal investigator at the Bacterial Immunopathology Lab at A*STAR ID Labs in Singapore. His work at A*STAR ID Labs revolves around three main pathogens: Mycobacterium tuberculosis, Gram-negative bacteria and Dengue virus.
Dr. Pablo Bifani
Dr. Bifani is a principal investigator at A*STAR ID Labs at their Antimicrobial Resistance Lab. He has extensively researched antimicrobial resistance in tuberculosis and malaria. He is also an associate professor and research director at the Yong Yoo Lin School of Medicine, National University of Singapore.
Professor and Head of Microbiology and Immunology Department, Faculty of Medicine, Lincoln University College (LUC) Malaysia.

Giants in history

Husband and wife team, Kimishige (3 December 1925 – 6 July 2018) and Teruko Ishizaka (28 September 1926 – 4 June 2019) discovered the antibody class Immunoglobulin E (IgE) that triggers allergic reactions. They also discovered that IgE antibodies attach to white blood cells, known as mast cells, releasing histamine, which causes allergic reactions.
Husband and wife team, Kimishige (3 December 1925 – 6 July 2018) and Teruko Ishizaka (28 September 1926 – 4 June 2019) discovered the antibody class Immunoglobulin E (IgE) that triggers allergic reactions. They also discovered that IgE antibodies attach to white blood cells, known as mast cells, releasing histamine, which causes allergic reactions.