Addressing antibiotic resistance: breath analysis aims to reduce unnecessary prescriptions

Pilot study lays the groundwork for future non-invasive diagnosis of bacterial infections.

The overuse of antibiotics gives harmful bacteria the opportunity to evolve into drug resistant strains that threaten health care. To help tackle the problem, scientists in China have begun a pilot study examining biomarkers exhaled by patients. The team’s goal is to develop an efficient (fast, accurate, painless and affordable) test that will assist doctors in prescribing antibiotics only when the treatment is absolutely necessary.

Reporting their first results in Journal of Breath Research, the researchers based at Zhejiang University have used benchtop analytical methods as a stepping stone towards developing future diagnostic tools.

The group is focusing its initial work on ventilator-associated pneumonia patients in the intensive care unit. Here it is critically important to differentiate between life-threatening bacterial infection and common colonization to avoid prescribing antibiotics unnecessarily.

“To confirm whether patients have a bacterial infection of the respiratory tract, doctors currently have to take a number of different samples (blood and sputum), and even chest x-rays in the case of pneumonia,” explained Kejing Ying, who is coordinating the work and is based at the Zhejiang University School of Medicine.

Breathe in, breathe out
Analysing samples from 60 volunteers, the scientists have found a potentially useful link between the presence of exhaled acinetobacter baumannii derived volatile organic compounds (VOCs) and patients diagnosed with bacterial pneumonia.

“The challenge we face is that many VOCs are not unique to one pathogen,” added Ying who is working with colleagues at Zhejiang University’s Department of Biomedical Engineering.

Ultimately, the team hopes that its research will lead to an approved non-invasive test to provide early warning of bacterial infection in the lower respiratory tract.


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The published version of the paper “Breath analysis for noninvasively differentiating Acinetobacter baumannii ventilator-associated pneumonia from its respiratory tract colonization of ventilated patients” (J Gao et al 2016 J. Breath Res. 10 027102) will be freely available online Wednesday 8 June. It will be available at DOI: 10.1088/1752-7155/10/2/027102.

Research team: Jianping Gao, Yingchang Zou, Yonggang Wang, Feng Wang, Lang Lang, Ping Wang, Yong Zhou and Kejing Ying.

Photograph of Kejing Ying, Zhejiang University, available on request.

About Journal of Breath Research
Journal of Breath Research is dedicated to all aspects of breath science, with the major focus on analysis of exhaled breath in physiology and medicine, and the diagnosis and treatment of breath odours. Go to (the link below).

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Published: 07 Jun 2016


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