PRESS RELEASE FROM NEUROPSYCHOPHARMACOLOGY
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Nicotine: An Addictive Pleasure
DOI: 10.1038/sj.npp.1300905
Always thought of as addictive, nicotine is now shown to induce a
progressive and long-lasting increase of sensitivity in the brain reward
systems, reports an online publication from the journal
Neuropsychopharmacology. In 2003, 45.4 million adults in the United States
were smokers. An estimated 70% of these said they wanted to quit. Previous
studies have concluded that nicotine is an addictive drug on par with heroin
and cocaine and this work may help us understand why it is so hard to kick
the habit.
In the first study of this kind, researchers studied the "pleasure center"
of the brain or the posterior lateral hypothalamus, and found that nicotine
caused the brain to register an enhanced reward value long after intake.
This differs from other drugs of abuse where there is usually a decrease in
brain reward systems.
Paul J. Kenny and Athina Markou found that rats voluntarily consumed
nicotine to increase the reward sensitivity in their brain. With a
relatively low dosage, administered just one hour a day, the brain is
alerted that nicotine is pleasurable and that this feeling is long lasting.
This long-lasting effect may be linked to the addictive properties of
nicotine and why it is not so easy to quit smoking - because your brain
remembers how good the last cigarette was.
Future research will focus on whether this enhanced sensitivity is reversed
with higher nicotine dosages and whether this leads to depression in chronic
smokers. Follow up studies will also investigate the potential role that
nicotine-induced reward hypersensitivity may play in perpetuating the
nicotine habit and the side effects of quitting smoking. One example for
consideration is whether reward hypersensitivity could increase the
appetitive value of food, thereby contributing to the weight gain seen in
former smokers.
Author contact:
Paul J. Kenny (The Scripps Research Institute, Jupiter, FL, USA)
Tel: +1 561 799 8903, E-mail: [email protected]
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