Tropical plant native to China reveals antiobesity potential

Osaka Metropolitan University scientists tested the antiobesity effects of Mallotus furetianus extract native to Hainan Island, China, using obesity model mice. As a result, body weight and adipose tissue weight of obesity model mice were significantly reduced by the intake of Mallotus furetianus extract. Fatty liver was suppressed and adipocyte size reduction in adipose tissue was observed. Further investigation into the mechanism revealed that fat synthesis is inhibited by suppressing the expression of several transcription factors involved in differentiation into adipocytes.

Mallotus furetianus, a tropical plant of the Euphorbiaceae family, native to Hainan Island, China.

Obesity, a major risk factor for various lifestyle diseases such as diabetes and hypertension has become widespread worldwide, inherently demanding innovative solutions to combat it.

A multi-institutional research group led by Associate Professor Akiko Kojima of the Graduate School of Human Life and Ecology at Osaka Metropolitan University, has made significant progress in the fight against obesity. The group had previously conducted a study on the effects of the extract of Mallotus furetianus (MFE),a tropical plant native to Hainan Island, China, on the prevention of fatty liver, but the antiobesity effects of MFE and its mechanisms had not been elucidated until now.

Using obesity model mice, the researchers set out to verify the antiobesity effects of MFEextract and the results were remarkable. Treatment with MFE significantly suppressed the increase in body weight and adipose tissue weight, and also demonstrated morphological changes in the liver and adipose tissue of the obesity model mice. Further investigation into the mechanism revealed that fat synthesis was inhibited by suppressing the expression of several transcription factors involved in adipocyte differentiation.

“Our research group is searching for food ingredients with antiobesity effects, based on the idea that if we can find and incorporate them into our daily diets, we can contribute to people's health and longevity,” stated Professor Kojima. “These results not only suggest a link between Mallotus furetianus extract and antiobesity effects but also indicate its potential as a new food ingredient with antiobesity properties.”

Their findings were published in Food Science & Nutrition.

 

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About OMU 

Osaka Metropolitan University is the third largest public university in Japan, formed by a merger between Osaka City University and Osaka Prefecture University in 2022. OMU upholds "Convergence of Knowledge" through 11 undergraduate schools, a college, and 15 graduate schools. For more research news visit https://www.omu.ac.jp/en/ or follow us on Twitter: @OsakaMetUniv_en, or Facebook

 

Published: 04 Aug 2023

Contact details:

Rina Matsuki

3-3-138 Sugimoto, Sumiyoshi-ku,
Osaka 558-8585 JAPAN

+81666053452
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Reference: 

Title: The suppression of the differentiation of adipocytes with Mallotus furetianus is regulated through the post-translational modifications of C/EBPβ
DOI: 10.1039/d2nh00576j
Author: Touko Nakano, Yutaro Sasaki, Toshio Norikura, Yusuke Hosokawa, Mayu Kasano, Isao Matsui-Yuasa, Xuedan Huang, Yoshinori Kobayashi, and Akiko Kojima-Yuasa
Publication date: 05 July 2023

Funding information:

JSPS KAKENHI, Grant/Award Number:15K00832