Genetics

Researchers from Osaka University have used a novel combination of short-read and long-read RNA sequencing to identify the different isoforms of genes expressed in the crustacean Daphnia magna. Males and females are genetically identical, but using this technique the team revealed genes that switch the predominant isoform in a sex-dependent manner. This study contributes to our understanding of Daphnia’s sexual dimorphism and helps further advance technologies in crustacean aquaculture.

Using image-based deep learning and dynamic shape classification techniques, SUTD researchers developed a novel method of checking red blood cell deformability that is less invasive, more cost-effective, more sensitive, and has higher throughput.

Classification of these plants bloom to double the number of taxonomic groups through morphological study, DNA analysis

Zika virus vaccine targets brain cancer, 120-year quest to farm lobsters, Arctic nightlife bursts with sound, Eating a robot, Molecular orientation is key & New treatment for ALS and dementia. Read all in the latest Editor's Choice.

Duke-NUS study reveals why some pancreatic and colorectal tumours resist targeted anti-Wnt drugs and suggests how to overcome it, offering new hope to patients with fully treatment-resistant cancers

Genetic analysis finds evidence suggesting that acoustic fat bodies in the heads of toothed whales were once the muscles and bone marrow of the jaw.

Asia Research News monitors the latest research news in Asia. Some highlights that caught our attention this week are where music affects our bodies, a battery powered by the oxygen inside our bodies, and the largest bird family tree to date.

Asia Research News monitors the latest research news in Asia. Some highlights that caught our attention this week are spiders that join together to transform into a flower, birds giving the right of way, and a potential natural treatment for hair loss.

Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are neurodegenerative diseases that commonly occur in middle-aged people. FTD is second only to Alzheimer's disease in terms of dementia prevalence. Both ALS and FTD arise from neuronal degeneration through mechanisms that remain unclear. Dr. Yun-Ru (Ruby) Chen's team in the Genomics Research Center (GRC), Academia Sinica recently discovered a new pathological mechanism for neuronal degeneration using synthetic peptides. They also discovered that a disaccharide can increase neuronal survival and reduce degeneration. The result provides therapeutic strategies for future treatment of these neurodegenerative diseases. The study was published in the top international journal "Science Advances" on February 23, 2024.

Asia Research News monitors the latest research news in Asia. Some highlights that caught our attention this week are the mechanisms behind regrowing limbs and middle-age weight gain, and a new wound dressing combining mussels and silkworms.

A novel method for studying genes in testicular cells of living animals could lead to breakthroughs in male contraception and fertility treatments.

A new user-friendly tool helps researchers explore how gene activity is influenced by chemical modifications, providing insights into disease and paths to new treatments.

Asia Research News monitors the latest research news in Asia. Some highlights that caught our attention this week are a closer step towards artificial spider silk, rocks made from plastic, and why a flightless dinosaur developed small wings.

Asia Research News monitors the latest research news in Asia. Some highlights that caught our attention this week are how a King Kongesque ape went extinct, how antibodies can make you dizzy, and a material that can break down harmful chemicals using the sun.

A previously mysterious small RNA molecule in mice is found to play a crucial role in gene expression, and may be the first identified member of a new class of regulatory RNAs.

Asia Research News monitors the latest research news in Asia. Some highlights that caught our attention this week are mouse embryos grown on the International Space Station, a super-efficient micro engine, and how a virus can help deaf children hear.

Asia Research News monitors the latest research news in Asia. Some highlights that caught our attention this week are parasites that borrow their hosts genes, how waste feathers can be used in hydrogen fuel cells, and a poor bird that was caught up in a powerful typhoon.

Risk-averse on/off-target assessment for CRISPR editing without reference genome

Researchers led by Osaka University developed a novel genome editing technique known as NICER, which results in significantly fewer off-target mutations than CRISPR/Cas9 editing. The technique uses a different type of enzyme that makes single-stranded “nicks” in the DNA. Repair of these nicks is more efficient and accurate than repair of double-strand breaks caused by the current CRISPR/Cas9 editing. This technique represents a novel approach for the treatment of genetic diseases caused by heterozygous mutations.

Asia Research News monitors the latest research news in Asia. Some highlights that caught our attention this week are the detection of a rare isotope of oxygen, converting waste coconut fibers into a flavoring compound, and a smart contact lens battery that can be powered by tears.

Roughly 10% of the proteins in our body rely on zinc. A group of researchers has unearthed the secrets behind a tiny but crucial protein that shuttles zinc ions within our bodies, offering a deeper understanding of how our cells maintain optimal health.

DNA and RNA, the two main types of nucleic acid and the building blocks of life, are susceptible to environmental stimuli, which can cause them to deform, bend or twist. These deformations can significantly affect gene regulation and protein functions, but they are extremely difficult to measure using traditional techniques. Recently, a research team co-led by a physicist from City University of Hong Kong (CityU) accurately measured the change in a nucleic acid induced by salt, temperature change and stretching force. Their findings help reveal the underlying universal deformation mechanisms of DNA and RNA.

Researchers from Osaka University have demonstrated a proof-of-concept for identifying single nucleotides by using quantum computing. Molecular rotation patterns—and the corresponding variations in conductance—within the nanoscale gap between two electrodes enabled the development of a quantum gate for the nucleotide adenosine monophosphate. Developing quantum gates for the other three nucleotides, and incorporating this technology into DNA sequencing workflows, could revolutionize genome analysis.

Illuminating the molecular ballet in living cells, Charting the voyage of marine plastics, A glimpse into the origins of life & Earliest human journeys to Asia. Plus Submissions open for Asia Research News 2024. Read all in the latest Editor's Choice.

Agricultural genetic stories reported at the International Congress of Genetics in Melbourne.

Research stories from the International Congress of Genetics in Melbourne Tuesday 18 July 2023

Highlights from the first two days of the 23rd International Congress of Genetics, Melbourne Australia For the next six days we will hear how genetics has transformed medicine, food, conservation, and almost every area of human activity.

New technological development has provided further clues about the origins of life on Earth. An international research group invented an innovative X-ray spectroscopy approach that enabled them to recreate the chemical reactions occurring in liquids at the femtosecond level (a quadrillionth part of a second). They used this to examine ureas—an organic compound that underwent ionization to form some of the building blocks of life.

A key protein for sperm maturation identified, Understanding gel formation, Urine test predicts organ diseases, A laser drills holes in a graphene film. Plus in our blog - The frogs of Borneo: more than just a race. Read all in the latest Editor's Choice.

A team led by researchers from Osaka University elucidated a molecular mechanism that is crucial for separating genetic material into daughter cells during cell division. A protein called CENP-C is part of a complex called the kinetochore, which supports the movement of chromosomes. Two portions of CENP-C, the CCAN-binding domain and Cupin domain, are needed for CENP-C to function. The Cupin domain repeats itself through oligomerization, which is essential for proper CENP-C function.