Genetics

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Scientists have developed a new computational tool that maps multi-gene pathways more comprehensively than ever before. The study uncovered a previously unknown protein pathway that, when blocked, kills blood cancer cells. The discovery could lead to new therapies for patients with drug-resistant blood cancers.

Untangling cosmic knots, Samurai jellyfish, Controlling rogue antibodies, Search for anti-ulcer vaccine & Metal-recovering yeast. Plus next SciCom coffee talk on experiences in science journalism in the AI era and WHO guide to reporting on non communicable diseases. Read all in the latest Editor's Choice.

SOSE researchers are looking at a possible vaccine for H. pylori, a widely common bacterium that causes stomach ulcers and raises the risk for stomach cancer.

A customizable protein has been developed to help the body remove harmful cells, such as those involved in cancer or autoimmune diseases, offering a potential new direction for treatments.

• International researchers led by Duke-NUS identify rare mutations in the SPNS1 gene as the cause of a previously undiagnosed multi-organ disorder • Faulty fat recycling in cells triggers damaging build-up in muscles and liver • Findings lay the groundwork for new therapies for affected families

A group of researchers led by The University of Osaka have identified a novel genetic mutation in Streptococcus pyogenes, a common bacterium which causes strep throat, significantly associated with severe invasive infections. A single mutation in the bacterial ferric ion transporter enhances bacterial growth in human blood. This mutation, unique to Japanese isolates, indicates a novel pathogenic mechanism. This world-first discovery offers a potential new target for treatments and preventive measures.

Researchers are one step closer to finding a common target for treating ALS - a fatal neurodegenerative disease that causes progressive muscle weakness.

Echoes of grief, Unexpected mineral, Insulin on edge, Fingerprinting bacteria, Beefing up taste & Power of glass. Read all in the latest Editor's Choice

Protein aggregation inhibitor shows lower levels of cell death and paralysis in mice with acute strokes

Stress-responsive gene pushes pancreatic insulin-producing cells toward dysfunction, fueling diabetes

Cyborg jellyfish, 3D collagen, Light, light go away, AI electronic nose, FLASHing cancer, Hydrogen storage in nanoscales & Can I drink this? Read all in the latest Editor's Choice

Scientists have identified a brain molecule called NEAT1 that appears to play a central role in triggering light sensitivity (photophobia), a common and debilitating symptom of migraines

New light-powered DNA detection enables more accessible, affordable genetic analysis

Suppression of the CcMCA1 gene has potential in halting invasive plant species

Constructed strain achieves record-high yield from methanol, advancing eco-friendly biomanufacturing

Advancement in veterinary regenerative medicine can help domestic and endangered wild cats alike

At Duke-NUS Medical School scientists are pioneering breakthroughs in precision medicine and regenerative therapies, targeting everything from muscle loss to dramatically extending our years of health.

A research team proposes a method to assess cancer patients for their likelihood to either respond to treatment or relapse.

Asia Research News monitors the latest research news in Asia. Some highlights that caught our attention this week are the genetics behind cat coat color, how AI and rat urine can help a robot fit in, and how plastic damages coral reefs.

Asia Research News monitors the latest research news in Asia. Some highlights that caught our attention this week are how to make a mouse from a single-celled organism, stimulating tastebuds in VR and how moving water actually ends up moving the planet.

Conversely, role in controlling cell proliferation might lead to novel tumor therapies in humans

Comprehensive analysis of quantitative changes in various proteins due to aging

A new portal linking Japanese genetic variant information with protein sequence and structure date has been launched by Protein Data Bank Japan (PDBj) and Tohoku University Tohoku Medical Megabank Organization (ToMMo). The portal simplifies the mapping of genetic variants to 3D protein structures and includes tools for visualization and analysis. It aims to advance medicine and drug discovery, particularly in precision medicine.

Asia Research News monitors the latest research news in Asia. Some highlights that caught our attention this week are how combining a drone and a platform can make heavy groceries easier to manage, the smallest dinosaur eggs found to date, and how to assemble DNA to store large amounts of data.

Mirror, mirror, in my tank, who’s the biggest fish of all? Sigma bond spotted, Balancing cell membrane, Exploring quantum squeezing and Outbreak preparedness. Read all in the latest Editor's Choice.

How multiple DNA binding proteins compete for the DNA substrate leads to different biochemical outcomes. Using single-molecule experiments, this work demonstrates that the regulatory protein Mei5-Sae3 complex stabilizes Dmc1 recombinases on RPA-coated DNA, leading to efficient RPA displacement and Dmc1 assembly, which in turn stimulates recombination progression.

A gene that limits cellular damage could be the key to surviving prolonged cold exposure.

A better understanding of how cells regulate their membranes could lead to new treatments for diseases such as epilepsy and anemia.

Studied oxidative stress and Parkinson’s disease as a case study