Genetics

Innovative research by scientists at Duke-NUS Medical School has shed light on the mysterious role of long non-coding RNAs in the development of pancreatic cancer and suggests potential new targets for precision cancer therapies.

A new apparatus improves how we study the effects of aiming high-field terahertz radiation at cells, with implications for regenerative medicine.

Marine biologists studying the genetic structure of the Humboldt squid population found it is vulnerable to overfishing by fleets on its migration path.

Scientists have found an ingredient that makes a vaccine more effective through an approach more often seen in materials science – testing molecules that self-assemble into larger structures.

Scientists found out why people with Zellweger syndrome also get sick with genetic disorders linked to dysfunctions of the cilia or the cell’s “antenna.”

A research team from the Department of Computer Science and Engineering (CSE) at The Chinese University of Hong Kong (CUHK) has developed a new Gene Expression Embedding frameworK (GEEK), which uses artificial intelligence technologies in machine learning and natural language processing to study the regulation of gene expression. In contrast to previous works that focused on one or a few regulatory mechanisms at a time, this new framework can study the joint effects of many mechanisms simultaneously. A research article describing this new study has been published in the renowned international science journal Nature Machine Intelligence. The framework may help study the causes of cancers and treatment methods.

Recurrent miscarriages (RM) cause frustration and trauma to couples who want to have a child. However, not all couples can find out about the underlying reasons because of medical constraints. The Department of Obstetrics and Gynaecology (O&G) of the Faculty of Medicine at The Chinese University of Hong Kong (CU Medicine) has successfully developed a new genome sequencing test called ChromoSeq to identify the genetic defects for married couples, who suffered from RM. When compared with the conventional karyotyping analysis, ChromoSeq offers greater accuracy in detecting potential genetic abnormalities associated with RM in affected couples. The team conducted a study on the innovation and the findings were recently published in the international journal American Journal of Human Genetics.

Prognosis describes how serious a patient’s cancer is and his or her chance of survival. A genetic biomarker is a clinically useful tool to help estimate the state of the disease. A study, conducted by the Faculty of Medicine at The Chinese University of Hong Kong (CU Medicine), has identified a gene called GPR18 which can be a biomarker to help form the prognosis for a patient in nine cancer types. The research team has also provided new insights into B-cells for a cancer patient’s prognosis. The findings were recently published in the international scientific journal Communications Biology - Nature.

Epstein-Barr virus rewires host epigenome to turn on latent genetic enhancers that activate proto-oncogenes, leading to tumorigenesis in stomach cancer

A method that involves infecting liver cells with mosquito-bred parasites could improve the study of malaria in India.

Scientists are looking for ways to make millions of molecule-sized robots swarm together so they can perform multiple tasks simultaneously.

A highly accurate machine learning tool could help doctors tailor individualized treatments for people with glioma brain tumours.

Singapore's National Supercomputing Centre fast track access for researchers involved in COVID-19 research. Applications are open from now until 23 September 2020.

A new compound with the potential to turn genes on and off could lead to new cancer and hereditary disease treatment strategies.

DGIST Professor Cheil Moon’s research team identified the molecular mechanism of innate olfactory behaviors. Clarified sensory defect accompanying neurodevelopmental disorder and cancer; will contribute to early diagnosis and improving anti-cancer drug side effects

A calf was born from an embryo lacking cells which form a large part of the placenta, providing new insight into the regenerative capacity of mammalian embryos.

Researchers at Kanazawa University report in the Journal of Thoracic Oncology a promising novel approach for a combined treatment of the most common type of lung cancer and associated secondary cancers in the central nervous system. The approach lies in combining two cancer drugs, with one compensating for a resistance side effect of the other.

Mice born blind have shown significant improvement in vision after undergoing a new gene therapy developed by a team of Japanese scientists.

Scientists suggest a new strategy that uses induced pluripotent stem cells (iPSCs) to regulate immune reaction to transplanted tissues.

A global research collaboration, led by world class institutions in Singapore, the UK and the USA, has developed the most detailed catalogue of mutational fingerprints found in most types of cancers that could help clarify their developmental history and lead to new prevention and treatment strategies.

Hokkaido University scientists are getting closer to understanding how a rare hereditary disease impairs the skin’s barrier function, which determines how well the skin is protected.

Testing for a gene expression pattern could reduce the number of colorectal cancer patients referred for unnecessary radical surgery.

First-of-its-kind study led by Duke-NUS Medical School and National Neuroscience Institute (NNI) applies experimental methodology using human neural cells and brain organoids to investigate mechanism underlying epileptic seizures in Angelman syndrome, an autism spectrum disorder.

Analysis of the Nomura’s jellyfish genome has identified unique genetic adaptations that helped them become early, successful multi-cellular predators.

A hyperactive gene response to Japanese encephalitis virus infection ultimately leads to brain inflammation.

Professor Dennis Yuk Ming LO and Professor Rossa Wai Kwun CHIU from the Faculty of Medicine at The Chinese University of Hong Kong (CUHK) have been named the “Top 20 Translational Researchers of 2018” by the world-renowned scientific journal Nature Biotechnology. They are the only Hong Kong scientists on the list and it is the third consecutive year for Professor Lo to receive this honour.

NUS researchers found that chevron patterns in fish swimming muscles require physical forces to correctly develop, not only from genetic instruction or biochemical pathways.

Researchers revealed the evolutionary changes in neurotransmitter uptake of VMAT1 by reconstructing ancestral VMAT1 proteins.

A team of researchers from the National University of Singapore has found that the effective population size and genetic diversity of Singapore’s Cynopterus brachyotis, believed to remain widely unaffected by urbanisation, has shrunk significantly over the last 90 years – revealing that the current biodiversity crisis may be much broader than widely assumed, affecting even species thought to be common and tolerant of fragmentation and habitat loss.

Scientists in Korea find a protein that mediates the interaction between the cellular systems involved in rapid responses against foreign genes in plants