Genetics

Prognosis describes how serious a patient’s cancer is and his or her chance of survival. A genetic biomarker is a clinically useful tool to help estimate the state of the disease. A study, conducted by the Faculty of Medicine at The Chinese University of Hong Kong (CU Medicine), has identified a gene called GPR18 which can be a biomarker to help form the prognosis for a patient in nine cancer types. The research team has also provided new insights into B-cells for a cancer patient’s prognosis. The findings were recently published in the international scientific journal Communications Biology - Nature.

Epstein-Barr virus rewires host epigenome to turn on latent genetic enhancers that activate proto-oncogenes, leading to tumorigenesis in stomach cancer

A method that involves infecting liver cells with mosquito-bred parasites could improve the study of malaria in India.

Scientists are looking for ways to make millions of molecule-sized robots swarm together so they can perform multiple tasks simultaneously.

A highly accurate machine learning tool could help doctors tailor individualized treatments for people with glioma brain tumours.

Singapore's National Supercomputing Centre fast track access for researchers involved in COVID-19 research. Applications are open from now until 23 September 2020.

A new compound with the potential to turn genes on and off could lead to new cancer and hereditary disease treatment strategies.

DGIST Professor Cheil Moon’s research team identified the molecular mechanism of innate olfactory behaviors. Clarified sensory defect accompanying neurodevelopmental disorder and cancer; will contribute to early diagnosis and improving anti-cancer drug side effects

A calf was born from an embryo lacking cells which form a large part of the placenta, providing new insight into the regenerative capacity of mammalian embryos.

Researchers at Kanazawa University report in the Journal of Thoracic Oncology a promising novel approach for a combined treatment of the most common type of lung cancer and associated secondary cancers in the central nervous system. The approach lies in combining two cancer drugs, with one compensating for a resistance side effect of the other.

Mice born blind have shown significant improvement in vision after undergoing a new gene therapy developed by a team of Japanese scientists.

Scientists suggest a new strategy that uses induced pluripotent stem cells (iPSCs) to regulate immune reaction to transplanted tissues.

A global research collaboration, led by world class institutions in Singapore, the UK and the USA, has developed the most detailed catalogue of mutational fingerprints found in most types of cancers that could help clarify their developmental history and lead to new prevention and treatment strategies.

Hokkaido University scientists are getting closer to understanding how a rare hereditary disease impairs the skin’s barrier function, which determines how well the skin is protected.

Testing for a gene expression pattern could reduce the number of colorectal cancer patients referred for unnecessary radical surgery.

First-of-its-kind study led by Duke-NUS Medical School and National Neuroscience Institute (NNI) applies experimental methodology using human neural cells and brain organoids to investigate mechanism underlying epileptic seizures in Angelman syndrome, an autism spectrum disorder.

Analysis of the Nomura’s jellyfish genome has identified unique genetic adaptations that helped them become early, successful multi-cellular predators.

A hyperactive gene response to Japanese encephalitis virus infection ultimately leads to brain inflammation.

Professor Dennis Yuk Ming LO and Professor Rossa Wai Kwun CHIU from the Faculty of Medicine at The Chinese University of Hong Kong (CUHK) have been named the “Top 20 Translational Researchers of 2018” by the world-renowned scientific journal Nature Biotechnology. They are the only Hong Kong scientists on the list and it is the third consecutive year for Professor Lo to receive this honour.

NUS researchers found that chevron patterns in fish swimming muscles require physical forces to correctly develop, not only from genetic instruction or biochemical pathways.

Researchers revealed the evolutionary changes in neurotransmitter uptake of VMAT1 by reconstructing ancestral VMAT1 proteins.

A team of researchers from the National University of Singapore has found that the effective population size and genetic diversity of Singapore’s Cynopterus brachyotis, believed to remain widely unaffected by urbanisation, has shrunk significantly over the last 90 years – revealing that the current biodiversity crisis may be much broader than widely assumed, affecting even species thought to be common and tolerant of fragmentation and habitat loss.

Scientists in Korea find a protein that mediates the interaction between the cellular systems involved in rapid responses against foreign genes in plants

Scientists have discovered non-coding RNA has a novel role to fine-tune gene expressions during stress recovery, getting closer to uncovering a 30-year-old nuclear mystery.

Despite great investments, an effective drug-based treatment for Alzheimer’s disease, the most common form of dementia among the elderly, remains elusive. Scientists led by Duke-NUS Medical School, in collaboration with Monash University, have published an online atlas of gene expressions at single-cell level in Alzheimer’s disease brains, aiming to boost to efforts to identify gene targets for drug development.

Four young researchers from The Chinese University of Hong Kong (CUHK) have been awarded China's Excellent Young Scientists Fund 2019. Each of them will receive a funding of RMB1.3 million to directly support their scientific research projects in Hong Kong to a maximum period of three years.

A team of researchers from City University of Hong Kong (CityU) and Karolinska Institutet has recently developed a new protein which can help increase the targeting accuracy in the genome editing process. It is believed that it would be useful for future gene therapies in human which require high precision.

A recent research led by a scientist at City University of Hong Kong (CityU) has discovered an easily transmitted DNA piece that can make a new type of hyper-resistant and deadly superbug become hyper-virulent quickly, posing an unprecedented threat to human health.

A research team from the School of Chinese Medicine at Hong Kong Baptist University (HKBU) has successfully developed a novel aptamer, i.e. a single-stranded piece of DNA, for the treatment of osteogenesis imperfecta (OI) with the aid of artificial intelligence (AI) technology. It is the first time a drug in Hong Kong has been granted orphan drug designation by the US Food and Drug Administration (FDA).

Comprehensive genomic information of largely understudied Asian populations will expand understanding on the biology of diseases.