Health

Duke-NUS, the only graduate-entry medical school in Singapore, has joined the TriNetX global research network to increase clinical trial adoption and to facilitate better collaboration with other global healthcare organizations (HCOs). This latest member for TriNetX in Asia will provide the network with access to de-identified data from more than a million patients.

A group of scientists have detected genetic material from SARS-CoV-2 in untreated wastewater samples collected in April 2020 from two wastewater treatment plants in Louisiana, USA.

Hong Kong has been experiencing hotter summers and more scorcher days in recent years due to climate change and heat island effect. Amid the increasing number of “hot nights”, it is found that consecutive “hot nights” are more detrimental to human health than “very hot days”, although the actual temperature does not reach the level of daytime, according to a collaborative research conducted by the Institute of Future Cities at The Chinese University of Hong Kong (CUHK), as well as researchers from the University of Hong Kong. The research also identified that lack of urban greenery and poor air ventilation in a high-density context are factors that lead to more “hot nights” than “hot days” in some areas. The team suggests that better urban planning and building design are long-term mitigation measures.

Hokkaido University scientists have shown that Interleukin-34 is a prognostic marker and drug target for Triple Negative Breast Cancer.

Uterine fibroid is a common benign gynaecological disease for women of reproductive age and often leads to heavy menstrual bleeding, pelvic pain and pressure related symptoms. Both surgical and non-surgical treatment options, such as High-Intensity-Focused-Ultrasound (HIFU), are available for patients nowadays. The Faculty of Medicine at The Chinese University of Hong Kong (CU Medicine) has developed a modified HIFU treatment protocol for patients with uterine fibroid. The innovative procedure implements a modified energy transmission protocol and oxytocin augmentation which has proved to provide better therapeutic outcomes than other non-surgical treatments. The findings were recently published in the international journal Ultrasound in Medicine & Biology.

Under the “Saving the Lives of Healthcare Workers” project in the Philippines, ASSIST and Project HOPE will distribute kits of personal protective equipment (PPE) to select hospitals and health facilities in COVID-19 hotspots in the Philippines.

Malignant glioma is the most common type of primary brain cancer. But lack of early diagnosis, among many other factors, has made it difficult to be treated. Recently, a team of cross-disciplinary scientists from City University of Hong Kong (CityU) has discovered new biomarkers in blood serum, which can be quantitatively detected by the label-free biosensors developed by the team, for the early detection of glioma progression. The findings enable a non-invasive liquid biopsy of glioma to be conducted, making it a promising diagnostic tool in the future.

Duke-NUS spinout, PairX, led by US and Singapore scientists and investors, to advance immunotherapy biotech exclusively licensed from Duke-NUS.

Researchers in China have taken the first step towards a new way of treating gastric wounds by using a microrobot combined with the new concept of “in situ in vivo bioprinting” to carry out tissue repair inside the body.

Forty-five of the world’s most influential leaders and innovators participated in EmTech Asia. They discussed how emerging technologies will influence industries related to artificial intelligence, robotics, sustainability, healthcare, immersive media, and more.

Scientists from the Daegu Gyeongbuk Institute of Science and Technology, Republic of Korea, discover a new way to diagnose Alzheimer’s disease by analyzing the levels of specific proteins in nasal discharge. This simple and inexpensive method could help in timely diagnosis of Alzheimer’s disease, in order to start treatment as soon as possible, thus delaying disease progression.

A large cohort study conducted by the Faculty of Medicine at The Chinese University of Hong Kong (CU Medicine), in collaboration with investigators from the University of Sydney, Australia, has discovered that shortened DNA telomere length is a useful biomarker linked to a higher risk of developing cardiovascular disease in patients with type 2 diabetes. The Endocrinology and Diabetes team of CU Medicine evaluated this biomarker in over 5,300 type 2 diabetes patients during a 13-year follow-up period. Patients with cardiovascular disease at baseline or during follow-up had shorter tail-ends of DNA strands, expressed as relative Leukocyte Telomere Length (rLTL), than those who never had cardiovascular disease. For each unit relative decrease in rLTL, the risk of cardiovascular disease increased by 25%. These results have been published in the leading diabetes journal, Diabetes Care.

Scientists have unveiled a correlation between high blood lead levels in children and methylation of genes involved in haem synthesis and carcinogenesis, indicating a previously unknown mechanism for lead poisoning.

Researchers from the Faculty of Medicine at The Chinese University of Hong Kong (CU Medicine) have recently conducted a study to investigate the impact of liver injury on clinical outcomes in COVID-19 patients. Data from over 1,000 COVID-19 patients in Hong Kong was analysed and liver injury was found in around 20% of the patients. The estimated risk of COVID-19 patients with liver injury experiencing adverse clinical outcomes such as intensive care unit (ICU) admission, use of invasive mechanical ventilation or death was almost eight times of other patients. It is suggested that liver function monitoring is important regarding its association with adverse clinical outcomes in COVID-19 patients. These findings have been published recently in the world-renowned medical journal Gut. In view of the high prevalence of various chronic liver diseases in the Asia-Pacific region, CU Medicine’s researchers led a group of experts from Mainland China, Japan, Singapore and Australia to issue a position statement on the management of COVID-19 patients with liver derangement. The statement has been published recently in another international medical journal The Lancet Gastroenterology & Hepatology.

Community rehabilitation; psychological impact of caregiving emerges as top interests

The somatic nuclear protein kinase VRK-1 increases the worm’s lifespan through AMPK activation, and this mechanism can be applied to promoting human longevity, the study reveals.

Recurrent miscarriages (RM) cause frustration and trauma to couples who want to have a child. However, not all couples can find out about the underlying reasons because of medical constraints. The Department of Obstetrics and Gynaecology (O&G) of the Faculty of Medicine at The Chinese University of Hong Kong (CU Medicine) has successfully developed a new genome sequencing test called ChromoSeq to identify the genetic defects for married couples, who suffered from RM. When compared with the conventional karyotyping analysis, ChromoSeq offers greater accuracy in detecting potential genetic abnormalities associated with RM in affected couples. The team conducted a study on the innovation and the findings were recently published in the international journal American Journal of Human Genetics.

Prognosis describes how serious a patient’s cancer is and his or her chance of survival. A genetic biomarker is a clinically useful tool to help estimate the state of the disease. A study, conducted by the Faculty of Medicine at The Chinese University of Hong Kong (CU Medicine), has identified a gene called GPR18 which can be a biomarker to help form the prognosis for a patient in nine cancer types. The research team has also provided new insights into B-cells for a cancer patient’s prognosis. The findings were recently published in the international scientific journal Communications Biology - Nature.

A study conducted over the past 18 years has found differences between lead exposure effects in young Japanese boys versus girls.

In a May 2020 Webinar, Dr. Sam Shah, Global Digital Health Advisor and Consultant with UK’s National Health System (NHS) discusses how the COVID-19 pandemic is reshaping healthcare with technology, specifically the response of UK’s NHS.

COVID19 is teaching us one more new lesson – to look for new-onset diabetes and other non-communicable diseases in COVID19 patients by post-COVID19 vigilance.

Epstein-Barr virus rewires host epigenome to turn on latent genetic enhancers that activate proto-oncogenes, leading to tumorigenesis in stomach cancer

A research group has developed a new, lightweight and motor-less device that can be easily attached to an ankle support device - otherwise known as an ankle foot orthosis (AFO). The new device will aid stroke patients in their rehabilitation, improving their walking and preventing falls.

The COVID-19 pandemic has thrown up unimaginable challenges for healthcare workers. Even simple outpatient procedures such as endoscopies can expose staff to the risk of infection.

Environmental pollutants threaten the health of marine mammals. This study established a novel cell-based assay using the fibroblasts of a finless porpoise stranded along the coast of the Seto Inland Sea, Japan, to better understand the cytotoxicity and the impacts of environmental pollutants on the porpoise population. The results revealed that the concentrations of PCBs and DDTs which accumulated in the porpoise are likely to have an adverse effect at the cellular level.

Acute kidney injuries can sometimes trigger the deterioration of small blood vessels and capillaries, leading to chronic kidney disease. But, this process is not completely understood. Now, for the first time, researchers from Daegu Gyeongbuk Institute of Science and Technology, Korea, in collaboration with teams from the University of Pittsburgh and University of Pittsburgh Medical Center, USA, have successfully used ultrasound super-resolution (USR) imaging to observe this process in live mice, revealing the promise of USR as a powerful diagnostic and research tool, and enhancing understanding of the disease.

Researchers from the School of Biomedical Sciences of the Faculty of Medicine at The Chinese University of Hong Kong (CU Medicine) have recently applied an advanced statistical approach to analyse risk factors that may be causally related to COVID-19 infection. Results suggested that diabetes may be a risk factor leading to increased susceptibility to or severity of COVID-19 infection through changes in ACE2 expression, which is a key receptor for the virus. A substantial proportion of COVID-19 death cases in Hong Kong suffered from diabetes. There is an urgent need to confirm risk factors and the mechanisms in order to protect the susceptible groups and identify effective treatments. The current study results were recently published in the international scientific journal Diabetes Care.

The JUL 2020 regular issue of the Journal of Humanities & Social Sciences Research (JHSSR), Volume 2 (1) JUL. 2020 has been published ahead of time on 30 Jun 2020 and is now live at the Journal’s webpage.

A method that involves infecting liver cells with mosquito-bred parasites could improve the study of malaria in India.

Digital edition of CAREhab – Singapore Rehabilitation Conference 2020 postpones to 17 – 18 July 2020 in light of Singapore General Elections