Japan
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22 Oct 2024
The University of Osaka
Researchers from Osaka University have discovered that GPR31, found in certain immune cells in the human gut, plays a key role in responding to bacterial metabolites and activating immune responses. Specifically, in the presence of metabolite pyruvate, these cells extend dendrites to sample the gut environment, detect pathogens, and activate T cells through GPR31. This discovery could inform the development of new drugs, vaccines, and probiotics that enhance gut immunity by targeting this pathway.
21 Oct 2024
The University of Osaka
Researchers from Osaka University have revealed a close link between polyploidy and DNA damage, showing that the presence of DNA damage increases the likelihood of polyploidization occurring, and that polyploid cells are more likely to accumulate DNA damage. However, polyploid cells can also tolerate higher levels of DNA damage, taking longer to enter damage-induced growth arrest and senescence. This discovery will aid the development of novel therapies for certain drug-resistant cancers originating from polyploid cells.
17 Oct 2024
Osaka Metropolitan University
Pathogenic system found on plasmid can lead to severe food poisoning symptoms
17 Oct 2024
Institute of Industrial Science, The University of Tokyo (UTokyo-IIS)
Researchers in Tokyo find that a 100-year-old method for redirecting water can be used to control heat dissipation in electronics
16 Oct 2024
Osaka Metropolitan University
Photoswitching and thermal switching properties allow writing by irradiation or heat and erasing by visible light
11 Oct 2024
Osaka Metropolitan University
Scientists visualize and control magnetic domains in quantum antiferromagnets
10 Oct 2024
Hokkaido University
An organic catalyst offers chemists precise control over a vital step in activating hydrocarbons.
10 Oct 2024
Osaka Metropolitan University
Fluorescein angiography capable of assessing neural blood flow in chronic nerve compression neuropathy
09 Oct 2024
Tohoku University
Fungi don’t have eyes or a brain, but their intelligent behaviours may surprise you! Research at Tohoku University suggests that fungi may be able to recognize shapes.
08 Oct 2024
Kanazawa University
Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, demonstrate how morphogens combined with cell adhesion can generate tissue domains with a sharp boundary in an in vitro model system.
08 Oct 2024
Ehime University
An unprecedented rapid increase in anthropogenic fingerprints around 1952 in the global strata reflects the point in time when humanity began to overwhelm the Earth system
08 Oct 2024
Osaka Metropolitan University
Surgery for discoid lateral meniscus in adolescence could lead to worsening complications and difficult solutions
07 Oct 2024
The University of Osaka
Researchers from Osaka University have created a high-performance polymer that can be chemically recycled without compromising its heat and chemical resistance. The revolutionary design includes a directing group that allows links in the polymer to be broken easily with a catalyst and the original polymer to be reformed in few steps. The directing group could be included in many polymers, potentially providing a new generation of high-performance plastics that can be recycled indefinitely.
07 Oct 2024
Tohoku University
Researchers at Tohoku University developed a novel method using facet-selective, ultrafine cocatalysts to efficiently split water to create hydrogen – a clean source of fuel.
04 Oct 2024
Ehime University
Successful selection of compounds inhibiting the function of a transcription factor
04 Oct 2024
Hiroshima University
Researchers performed two studies to better characterize the effects of job embeddedness, or factors that influence an employee’s commitment to their job, on voluntary turnover in the face of job insecurity.
04 Oct 2024
Osaka Metropolitan University
Future of bioplastics made from carbon dioxide and biomass molecules could rely on more enzymes, shorter incubation periods
03 Oct 2024
Osaka Metropolitan University
Hepatocellular carcinoma recurrence related to proper weight and diabetes regulation
02 Oct 2024
Osaka Metropolitan University
Solid electrolyte composed of nanoparticles embedded in an amorphous matrix shows high conductivity, formability, and electrochemical stability
01 Oct 2024
Osaka Metropolitan University
Using real-world information written in Japanese, large language model displays accuracy on par with neuroradiologists
01 Oct 2024
Hokkaido University
A gene that limits cellular damage could be the key to surviving prolonged cold exposure.
30 Sep 2024
Osaka Metropolitan University
A study on factors that contribute to population changes based on city size
25 Sep 2024
Hokkaido University
The discovery of a stable single-electron covalent bond between two carbon atoms validates a century-old theory.
25 Sep 2024
Ehime University
The Androgen Receptor in Mesenchymal Progenitor Cells Drives Skeletal Muscle Mass Regulation
25 Sep 2024
The University of Osaka
A research team led by Osaka University has developed Japan's first biomolecular sequencer prototype, crucial for gene-based cancer diagnosis and treatment. After 16 years of research, the team, led by Professors Taniguchi and Ohshiro, collaborated with H.U. Group Research Institute and Sony Global Manufacturing & Operations Corporation to overcome technical challenges. The team plans to enhance the device with AI for accurate diagnostics and to advance peptide drug discovery.
25 Sep 2024
Osaka Metropolitan University
By targeting multiprotein molecule, antibody inhibits bacteria’s growth, pathogenicity
25 Sep 2024
Osaka Metropolitan University
Study shows that ancient reef-building stromatoporoids survived the Late Devonian extinction and continued to thrive during the Carboniferous Period
24 Sep 2024
Osaka Metropolitan University
Propylene production harnesses biodiesel waste byproduct
24 Sep 2024
Tohoku University
Analyzing fossils can be difficult – especially when they're so small that they can only be seen with a microscope. Researchers at Tohoku University have come up with a solution.
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Giants in history
Japanese biochemist Akira Endo (1933 – 2024) discovered the first statin, called mevastatin, which lowered cholesterol levels in the blood by inhibiting a key enzyme in the cholesterol biosynthesis pathway. His work laid the foundation for the development of statins to help patients lower their blood cholesterol levels and reduce their risk of heart disease or stroke.
Ruby Sakae Hirose (1904 – 1960) was a Japanese-American scientist whose research contributed significantly to our understanding of blood clotting, allergies and cancer.
Haisako Koyama (1916 – 1997) was a Japanese solar observer whose dedication to recording sunspots – cooler parts of the sun’s surface that appear dark – produced a sunspot record of historic importance.
Michiaki Takahashi (17 February 1928 – 16 December 2013) was a Japanese virologist who developed the first chickenpox vaccine.
Toshiko Yuasa (11 December 1909 – 1 February 1980) was the first Japanese female physicist whose research on radioactivity shed light on beta decay – the process in which an atom emits a beta particle (electron) and turns into a different element.
Baron Kitasato Shibasaburo (29 January 1856 – 13 June 1931) was a Japanese physician and bacteriologist whose work led to a new understanding of preventing and treating tetanus, diphtheria and anthrax.
By isolating soil microorganisms and studying the compounds they produce, Satoshi Omura (born 1935) discovered almost 500 organic compounds with unique properties that were produced by these microorganisms, including many new antibiotics.
Husband and wife team, Kimishige (3 December 1925 – 6 July 2018) and Teruko Ishizaka (28 September 1926 – 4 June 2019) discovered the antibody class Immunoglobulin E (IgE) that triggers allergic reactions. They also discovered that IgE antibodies attach to white blood cells, known as mast cells, releasing histamine, which causes allergic reactions.
Husband and wife team, Kimishige (3 December 1925 – 6 July 2018) and Teruko Ishizaka (28 September 1926 – 4 June 2019) discovered the antibody class Immunoglobulin E (IgE) that triggers allergic reactions. They also discovered that IgE antibodies attach to white blood cells, known as mast cells, releasing histamine, which causes allergic reactions.
Reiji Okazaki (8 October 1930 – 1 August 1975) and Tsuneko (7 June 1933) were a Japanese couple who discovered Okazaki fragments – short sequences of DNA that are synthesized during DNA replication and linked together to form a continuous strand.
In 1915, Koichi Ichikawa along with pathologist Katsusaburo Yamagiwa became the first to prove that chronic exposure to chemicals can cause cancer.
In 1915, pathologist Katsusaburo Yamagiwa and his research assistant Koichi Ichikawa became the first to prove that chronic exposure to chemicals can cause cancer.
Ogino Ginko (3 March 1851 – 23 June 1913) was the first registered female doctor to practise modern medicine in Japan.
Michiyo Tsujimura (17 September 1888 – 1 June 1969) was a Japanese agricultural scientist and biochemist recognized for her research of green tea components.
Hitoshi Kihara (1893 – 1986) was one of the most famous Japanese geneticists of the 20th century. One of his most significant contributions was identifying sex chromosomes (X and Y) in flowering plants.
Kono Yasui (16 February 1880 – 24 March 1971) was a Japanese botanist who researched the genetics of poppies, corn and spiderworts and surveyed the plants that had been affected by the nuclear fallout after the atomic bombings of Hiroshima and Nagasaki.
Umetaro Suzuki (7 April 1874 – 20 September 1943) was a Japanese scientist best remembered for his research on beriberi, a disease caused by vitamin B1 deficiency, characterized by limb stiffness, paralysis and pain.
Kikunae Ikeda (8 October 1864 – 3 May 1936) was a Japanese chemist who discovered the fifth basic taste, umami.
Osamu Shimomura (27 August 1928 – 19 October 2018) was a Japanese organic chemist and marine biologist who dedicated his career to understanding how organisms emitted light.
Motoo Kimura (13 November 1924 – 13 November 1994) was a Japanese theoretical population geneticist who is best remembered for developing the neutral theory of molecular evolution.
Chika Kuroda (24 March 1884 – 8 November 1968) was a Japanese chemist whose research focussed on the structures of natural pigments.
The field of solid-state ionics originated in Europe, but Takehiko Takahashi of Nagoya University in Japan was the first to coin the term ‘solid ionics’ in 1967. ‘Solid-state ionics’ first appeared in 1971 in another of his papers, and was likely a play on ‘solid-state electronics’, another rapidly growing field at the time.
The techniques that make industrial pearl culturing possible were developed over a century ago at the Misaki Marine Biological Station in Japan. The station’s first director, Professor Kakichi Mitsukuri, emphasized to Kokichi Mikimoto in 1890 that stimulating pearl sac formation was important for pearl growth, and they went on to successfully develop methods for culturing pearls.
Japanese physicist Ukichiro Nakaya (1900-1962) made the world’s first artificial snowflakes. He started his research on snow crystals in the early 1930s at Hokkaido University, where there is an unlimited supply of natural snow in winter. By taking over 3,000 photographs, he established a classification of natural snow crystals and described their relationship with weather conditions.
Minoru Shirota (April 23, 1899 – March 10, 1982) was a Japanese microbiologist who invented the popular fermented drink Yakult.
Japanese chemist Kenichi Fukui (4 October 1918 – 9 January 1998) was the first Asian scientist to be awarded the Nobel Prize in Chemistry. Together with Roald Hoffman, he received this honour in 1981 for his independent research into the mechanisms of chemical reactions.
Shinichiro Tomonaga (31 March 1906 – 8 July 1979), together with Richard Feynman and Julian Schwinger, was awarded the Nobel Prize in Physics in 1965, for their contributions to advance the field of quantum electrodynamics. Tomonaga was also a strong proponent of peace, who actively campaigned against the proliferation of nuclear weapons and promoted the peaceful use of nuclear energy.
Hideki Yukawa (23 January 1907 – 8 September 1981) was awarded the Nobel Prize in Physics in 1949 for predicting the existence of the pi meson subatomic particle. Japan’s first Nobel laureate, Yakawa also expressed his support for nuclear disarmament by signing the Russell–Einstein Manifesto in 1955.
Japanese chemist Takamine Jokichi (3 November 1854 – 22 July 1922) founded the Tokyo Artificial Fertilizer Company, where he isolated a starch-digesting enzyme (named takadiastase) from the fungus Aspergillus oryzae.
Tsuneko (7 June 1933) and Reiji Okazaki (8 October 1930 – 1 August 1975) were a Japanese couple who discovered Okazaki fragments – short sequences of DNA that are synthesized during DNA replication and linked together to form a continuous strand.
A Japanese surgeon, Tetsuzo Akutsu (20 August 1922 – 9 August 2007) built the first artificial heart capable of keeping an animal alive.
Japanese geochemist Katsuko Saruhashi developed the first method and tools for measuring carbon dioxide in seawater



























































