Medicine & Healthcare Internal medicine
News
10 Jun 2026
Physician-scientists at Kanazawa University have demonstrated, for the first time worldwide, the clinical efficacy of chemoimmunotherapy in patients with ultra-rare urachal cancer. Furthermore, their reverse translational research elucidated the mechanism by which the addition of immunotherapy enhances the efficacy of chemotherapy.
02 Jun 2026
Researchers from The University of Osaka found that nanomicelle-mediated delivery of five mRNAs involved in angiogenesis, heart cell contraction, immune and hematopoietic stem cell recruitment, and immune response suppression promoted cardiac repair and increased overall survival in a mouse model of myocardial infarction–induced heart failure. These findings suggest that a multifactorial treatment approach effectively addresses the complex nature of heart failure and could aid new treatments in regenerative medicine for cardiovascular disease.
26 May 2026
Researchers from The University of Osaka have found that the rat brain differs from other mammals in the proportion of upper and deep layer neurons in the cortex. This change likely arises from differences in the timing of signaling pathways during early brain development. Importantly, this identified mechanism may have future applications in regenerative medicine for developmental and neurological disorders.
26 May 2026
Researchers studied 23 cases of oral cancer with a burrowing growth pattern and found that rare carcinoma cuniculatum has a unique genetic fingerprint. The research found genetic alterations in FAT1, NOTCH1, PIK3CA, and CASP8, suggesting a potential explanation for its slow growth and favorable prognosis. These findings suggest that genetic testing could improve diagnosis and inform treatment decisions in oral cancer.
21 May 2026
Researchers from The University of Osaka found that only a small subset of tumor-killing T cells undergoes extensive expansion during immunotherapy for multiple myeloma. By tracking individual cells, the team showed that the T-cell clones that later became dominant had already begun expanding shortly after the treatment started. The findings also suggest that highly proliferative immune cells show lower levels of exhaustion-related markers, offering new insights into why some patients respond better to immunotherapy.
23 Apr 2026
Researchers from The University of Osaka have discovered a new class of antibodies, called iTabs, that naturally suppress specific immune responses by blocking immune cell activation. These antibodies can reduce autoimmune disease severity in mice, suggesting a new way to treat conditions like multiple sclerosis without weakening the immune system overall.
31 Mar 2026
Hiroshima University researchers have developed a practical framework to identify candidate pathogenic variants hidden among the large number of variants of uncertain significance (VUS) detected in comprehensive genomic profiling (CGP) of cancers. This framework could improve the accuracy of precision oncology by more reliable prioritization of VUS.
25 Mar 2026
Researchers from The University of Osaka found that leukemia caused by NUTM1 rearrangements is distinguished from other forms of B-cell acute lymphoblastic leukemia (B-ALL) by a unique pattern of gene activity and gene regulation. Unlike the common form of B-ALL caused by KMT2A rearrangement, which is resistant to treatment, leukemic cells with NUTM1 rearrangements are highly sensitivity to chemotherapy.
16 Mar 2026
Through protein binding, molecular heavy drugs are effectively transported to cancerous tissues
06 Mar 2026
Researchers at the Cancer Research Institute and the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, have uncovered a critical mechanism that enables gastric cancer to spread to distant organs. Their study shows that cancer cells stimulate Wnt signaling in surrounding stromal fibroblasts to produce hyaluronan, creating a supportive microenvironment that promotes metastasis.
These findings provide new insight into how metastatic tumors establish themselves and suggest promising strategies to prevent gastric cancer progression.
04 Mar 2026
Researchers from The University of Osaka have found that potassium KCNQ2/3 channels in the brain, which are important for suppressing cell excitability, need to be fully functional to be trafficked to the appropriate part within the nerve cell and work properly. This link between channel functionality and localization may have important consequences for the development of therapies against KCNQ2/3-related epilepsy.
02 Mar 2026
Researchers at Hiroshima University and Gifu Kyoritsu University identified Hepatitis B RNA serum levels as a biomarker that more accurately stratifies risk of liver cancer in individuals who have been functionally cured of chronic hepatitis B.
27 Feb 2026
Researchers from The University of Osaka have found that a specific signaling pathway, the integrin αV–YAP–CTGF axis in liver sinusoidal endothelial cells, may be associated with the development of liver fibrosis, portal hypertension, and liver cancer in patients with chronic liver congestion. These findings have important implications for the development of therapies aimed at preventing more severe forms of liver disease.
05 Feb 2026
Study highlights the uniqueness of individual brain functional connectomes as a promising approach to identify biomarkers for major depressive disorder.
29 Jan 2026
Researchers from The University of Osaka report the development of two fluorescent indicators, Gachapin and Gachapin-C, that can be used to monitor cell–cell contacts and contacts between different processes of the same neuronal cell. Unlike split GFP indicators, the reversible and instant fluorescence from the Gachapin/Gachapin-C chromophore upon contact enables real-time imaging of dynamic contact events.
26 Jan 2026
Lymphatic Drug Delivery System (LDDS) is an emerging type of cancer treatment, but its efficacy depends on how efficiently the drugs reach the lymphatic system. A research team from Tohoku University has clarified how the physical and chemical features of medicines affect how they move through the lymphatic and blood systems, helping to advance the clinical development of LDDS.
16 Jan 2026
Symptoms of depression are common among people with asthma, but growing evidence suggests they may arise from biological mechanisms different from those underlying major depressive disorder.
13 Jan 2026
A research team at The University of Osaka revealed that the loss of heterochromatin can cause a chain reaction leading to genetic changes and the subsequent development of diseases including cancer. Using fission yeast, the study specifically found that loss of Clr4, which encodes a methyltransferase, can induce an increase in R-loop levels at pericentromeric repeats, and the later conversion of R-loops into ADR-loops can prompt gross chromosomal rearrangements.
09 Jan 2026
Scientists at the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, have captured real-time images showing how a key brain enzyme organizes itself to help memory formation. Their study, published in Nature Communications, reveals that the enzyme CaMKII forms mixed α/β subunit structures whose interactions stabilize learning-related signals in neurons.
29 Dec 2025
Findings connect Fusobacterium nucleatum with multiple sclerosis disease severity
10 Dec 2025
Researchers from The University of Osaka have developed a novel reverse genetics system to study norovirus, the leading cause of gastroenteritis. This efficient system can generate infectious viral particles by simply injecting viral genetic material into zebrafish embryos. They were able to alter the genetic material to create modified viruses, enabling the evaluation of antiviral drugs and novel vaccine development. The advances provided by this new system will have a significant effect on public health.
09 Dec 2025
Brain atlas, From perfume to plastic, Stable solar power, Plant aging switch, Anti-cancer droplets, Greener gold, Extreme star factory and How research shapes sustainability policy. Read all in the latest Editor's Choice.
08 Dec 2025
Researchers from The University of Osaka found migration of glucose and fructose from the blood to saliva drives oral microbiome dysbiosis in patients with type 2 diabetes, increasing the development of dental caries. This suggests that glycemic control could be an effective strategy for controlling dental caries in this population.
17 Nov 2025
Researchers at The University of Osaka developed the Balloon-Assisted Bronchoscope Delivery (BDBD) technique and in a first-in-human clinical trial, the team successfully demonstrated that this technique is both safe and effective, enabling access to lesions smaller than 20 mm. By using a small balloon to gently widen airways, it allows endoscopes to reach deep, peripheral lung tumors, promising more accurate cancer diagnosis and new minimally invasive treatment options.
14 Nov 2025
Untangling cosmic knots, Samurai jellyfish, Controlling rogue antibodies, Search for anti-ulcer vaccine & Metal-recovering yeast. Plus next SciCom coffee talk on experiences in science journalism in the AI era and WHO guide to reporting on non communicable diseases. Read all in the latest Editor's Choice.
11 Nov 2025
Researchers have developed an eco-friendly method to create gold nanoparticles (AuNPs) using microalgae. This "green synthesis" avoids harsh chemicals, resulting in nanoparticles that are more stable than conventional ones. When activated by a laser, these AuNPs effectively destroy cancer cells while showing lower toxicity to healthy cells. This breakthrough promises a more sustainable and safer approach to photothermal cancer therapy and other applications in nanomedicine.
10 Nov 2025
UOsaka and MIT scientists revealed that the motor proteins KIF18A and CENP-E work together to align chromosomes during mitosis. Cancer cells with reduced CENP-E levels are especially sensitive to KIF18A inhibition, and dual inhibition of both proteins leads to efficient cell death. The discovery offers new insights into chromosome mechanics and a potential strategy for targeted cancer therapy.
05 Nov 2025
Researchers from The University of Osaka have found that rituximab, a monoclonal antibody approved for the treatment of nephrotic syndrome in children in Japan, also improves disease management in adults. The drug kept adults with frequently relapsing nephrotic syndrome or steroid-dependent nephrotic syndrome relapse-free for longer, compared with placebo, with good safety. By reducing the frequency of relapses, rituximab may reduce the reliance on corticosteroids and help to improve quality of life among adult patients with these challenging conditions.
08 Oct 2025
Researchers at The University of Osaka have discovered precursor T follicular regulatory cells (preTfr), comprising 30-50% of circulating Tfr in human blood. preTfr are significantly reduced in severe COVID-19 and sepsis, correlating with increased anti-interferon-gamma autoantibodies and activated atypical B cells. Unlike stable conventional naïve regulatory T cells, preTfr are specifically depleted during severe disease. When stimulated, preTfr up-regulate suppressive molecules including IL-1RA and show enhanced wound healing capacity. Conversely, mRNA vaccination increases preTfr frequency, suggesting controlled immune participation. The findings identify preTfr as a therapeutic target for preventing autoantibody production during severe infections.
08 Oct 2025
Researchers investigated how autoimmune gastritis alters the gastric microbiota and disrupts metabolism, shedding light on mechanisms that contribute to the development of neuroendocrine tumors.
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Researchers
Dr. Ashfaq Ahmad Shah 'اشفاک,' born on 6 June 1992, from south Kashmir, Dodarkoot ددیرکوٹ Kulgam, Jammu and Kashmir, India, is the microbiologist whose broad area of specialization incorporates infection immunity. He served as a researcher at the Graphic Era (Deemed to be University), Dehradun, UK, India, from 2020 to 2025. Currently he is working as Postdoctoral researcher and Junior Scientist in the KIET School of Pharmacy at KIET University. As a microbiology scientist, Dr. Shah has pursued novel dimensions of infection immunity pertaining to the correlation and impact of elicitation-triggered phytoalexins and phytoanticipins on the benign immune system of human beings. This parameter of immunology is termed phytoalexin-immunomodulation scrutiny in the contemporary era. Dr. Shah's research encompasses a range of areas, including the indagation on anti-inflammatory and antimicrobial compounds, evaluation of antibiotic resistance, study of immunomodulatory activities, disease model studies, protease isolation against specific protein antigens, study of novel compounds via the hyphenated techniques of GCMS, HPLC, FTIR-MS, etc., and the discipline of kalology, including tyrosinase inhibition, PPO inhibition, skin whitening agents, kerato-peeling, etc. Dr. Ashfaq is a scientist, doctoral researcher, reviewer, and editorial member of several journals and books of national and international repute. He has contributed extensively to scientific literature by publishing his research in journals of national and international repute. So far he has published more than forty infection/immunology/pharmacology scientific papers in Scopus and SCI-indexed journals, including two international books. In recognition of his contributions, Dr. Shah received the Young Scientist Award in August 2023 for his groundbreaking academic performance in the field of infection immunity. Dr. Shah has also been an active editor of Wikipedia pages in the field of medical science since 2015, with more than 1000 edits in medical topics available to medical literature worldwide.
Giants in history
Barry Paw (29 August 1962 – 28 December 2017) was a biologist and oncologist who discovered several novel genes and their functions in red blood cells.
A Japanese surgeon, Tetsuzo Akutsu (20 August 1922 – 9 August 2007) built the first artificial heart capable of keeping an animal alive.