Medicine & Healthcare

Popular milk and dairy products in Egypt show over 25% prevalence of E. coli

Advancement in veterinary regenerative medicine can help domestic and endangered wild cats alike

Verifying the Esophageal Hypervigilance and Anxiety Scale for clinical use

N-Cadherin is found to boost cardiomyocyte regeneration after injury by stabilizing β-Catenin, suggesting a potential new way to improve the function of human failing hearts.

As populations age worldwide, diseases like pulmonary fibrosis are increasingly impacting life expectancy and quality. Duke-NUS researchers have identified that blocking specific proteins in immune cells can significantly reduce or reverse lung scarring. This discovery paves the way for novel treatments that could potentially reverse damage from pulmonary fibrosis.

Researchers from Osaka University found that peristaltic pump flow mechanically breaks supersaturation to induce amyloid formation by hen egg white lysozyme, α-synuclein, amyloid β 1-40, and β2-microglobulin. The high shear stresses induced by peristaltic flow likely reflect those that occur the blood and cerebrospinal fluid, suggesting that this factor could promote amyloidosis.

A bilayer alginate hydrogel system encapsulating polyelectrolyte complex nanoparticles (PCNs) loaded with anti-inflammatory cytokines and angiogenic growth factors, which reducing inflammation, stimulating angiogenesis, and accelerating wound closure in a diabetic murine model.

A multi-institutional research team led by Osaka University found that tricaprin, a natural supplement, improved long-term survival rates in patients with triglyceride deposit cardiomyovasculopathy, a new type of heart disease characterized by impaired triglyceride breakdown in heart and smooth muscle cells. Tricaprin improved clinical symptoms and long-term survival. Studying the effects of tricaprin on patients of different ethnicities would be an ideal next step to gather more evidence in favor of the drug.

A team from Osaka University has developed scSPOT, a new technique that reveals how immune cells called Tregs simultaneously control the immune system. The team identified key immune cells controlled by Tregs and found that Tregs are targets for the cancer drugs ipilimumab and tazemetostat. They also found that Tregs are indicators of serious viral infection. This valuable technique may accelerate the development of treatments for cancer and other diseases.

· Microbes affect pathways in the brain that regulate our anxiety levels. · Microbe secreting metabolites—indoles—alleviate anxiety levels. · Indigenous microbes producing indoles open avenues for an alternative treatment therapy using probiotic microbes producing indoles to reduce anxiety attacks—thus a vision of next generation therapy to combat mental health disorders.

Researchers from Japan find that certain antioxidant enzymes, called selenoproteins, significantly contribute to fighting cell aging. The team used a gene knockout mouse model to help them study the effects of disrupting selenoprotein synthesis. This knockout negatively impacted hematopoietic stem cells and B cell-lineage immune cells, which was driven by the lack of selenoprotein-mediated fighting of lipid peroxides. These phenotypes mimic what is observed in age-related diseases, emphasizing the importance of selenoproteins in these disorders.

Amylase and mucin decrease the effects of ozonated water

Latest findings on the significance and interaction between cell death and cellular senescence in cancer

At Duke-NUS Medical School scientists are pioneering breakthroughs in precision medicine and regenerative therapies, targeting everything from muscle loss to dramatically extending our years of health.

Ultrasound charging for biomedical devices penetrates the body better and researchers have shown that the receiver’s shape improves energy transfer.

A new treatment with iron nanoparticles and nitric oxide gas shows promise in destroying oral cancer cells.

The study identifies gut microbes and genes that regulate TMAO production from L-carnitine, offering potential for personalized nutrition strategies.

Intermittent fasting, especially alternate-day fasting, provides an effective alternative to continuous energy restriction for improving metabolic health.

A research team proposes a method to assess cancer patients for their likelihood to either respond to treatment or relapse.

Crossing the uncanny valley, Batteries that don’t explode, Tiny climate change fighters, Liver-friendly mushroom & Foetal defence. Read all in the latest Editor's Choice.

• The legacy of Duke-NUS’ founding donor, the Estate of Khoo Teck Puat, continues with a transformative S$5.5 million gift towards research. • The HEAD Foundation steps up with a S$200,000 scholarship, underpinning Duke-NUS’ commitment to developing medical expertise.

Duke-NUS study findings challenge the longstanding reliance on neutralising antibodies for assessing viral immunity, and suggest that development of future vaccines must consider both antibody and T-cell responses for comprehensive protection.

Gut microbe isolated from infertile women disrupts progesterone metabolism, lowering progesterone levels and impairing ovarian follicular development.

Ateneo researchers are looking to turn milkfish skin, a common waste byproduct of the Philippine fishing industry, into an invaluable medical resource.

New formula for hyperfiltration and glomerular filtration rate takes natural decline into account

Early administration of AHCC at the stage of hepatitis might hold possibility of preventing onset of cirrhosis

Researchers have found that adding sugar or artificial sweetener to drinks with caffeine gives a significant boost to the sleep-wake period in mice

Use of automated system in upper extremity paralysis care proves beneficial for patients and medical staff

Researchers from Osaka University have revealed some of the precise mechanisms by which erroneous cells are recognized, marked for removal, and eliminated via apoptosis in developing zebrafish. Notably, they found that the protein Foxo3 may be a universal marker of cell competition in zebrafish and mice. These findings have important implications for congenital disorders, cancer, and aging, and may lead to novel treatments.

Utilizing pericellular and intracellular controlled-release of carboplatin to precisely synergize with reduced-dose radiotherapy, aiming to eradicate malignant gliomas.