Medicine & Healthcare

A specially designed lipid nanoparticle could deliver immune-signaling molecules into liver macrophage cells to overcome resistance to anti-tumor immunotherapy.

Genetic and epigenetic profiling of hundreds of hepatoblastoma tumors have revealed many of its secrets, long unknown to those researching and treating what is the most common type of liver tumor in children.

When it comes to cancer, clarity is key. The ability to visualize cancerous tumors and metastatic tissue three dimensionally (3D) can help clinicians diagnose the precise type and stage of cancer, while also informing the best treatment methods. To obtain an even clearer tissue for imaging, a research team based in Japan has tested the effectiveness of specialized hydrogels. Acting as a 3D molecular network, these hydrogels can rapidly remove fats from tissues, which are a factor in tissue opacification, without losing their structure. The material is used in several biomedical devices, including contact lenses.

Abnormally high levels of DNA methylation have been identified in dogs exposed to high levels of lead near a mining area in Kabwe, Zambia, by a team of scientists from Japan and Zambia.

Researchers have identified a potential reason why lower numbers of COVID cases have appeared amongst smokers compared to non-smokers, even as other reports suggest smoking increases severity of the disease.

Researchers at the University of Tsukuba in Japan show that low metabolic flexibility is associated with reduced fat metabolism during sleep.

Researchers from the University of Tsukuba and Kyoto University find that capillary blood flow in the brain, which is important for delivering oxygen and nutrients and removing waste products, is increased in mice during the dream-active phase of sleep.

Researchers from University of Tsukuba in collaboration with Yamagata University scientists find that exposure to light with less blue before sleep is better for energy metabolism. Extended exposure to light during nighttime can have negative consequences for human health. But now, researchers from Japan have identified a new type of light with reduced consequences for physiological changes during sleep.

Miyagi Prefecture and Tohoku University Hospital have set up an Antibody Cocktail Therapy Centre in Sendai. The treatment, which involves artificial monoclonal antibodies administered through an intravenous drip, is aimed at preventing patients with mild COVID-19 from becoming seriously ill.

A research team led by Hiroshima University Professor Satoshi Okada has determined that enhanced bone resorption activity due to a faulty immune response may underpin multifocal osteomyelitis — painful, chronic bone infections — in children with MSMD, a rare genetic condition resulting from a range of immune system mutations.

Recreating major pathological features of Parkinson’s disease in a lab-grown, human mini-brain will help researchers to explore new treatments. This is the first time that Lewy bodies, a hallmark of Parkinson’s disease in patients’ brains, have been produced in the laboratory, offering new insights into the disease.

A synthetic CDK4/6 inhibitor exerts antitumor effects by forcing RB1 tumor-suppressor into an active status, but its single administration is not sufficiently effective. We find its combinatorial administration with an IKKβ inhibitor is significantly more effective in hepatocellular carcinoma treatment. Also, blockage of the IKK-NF-κB or AKT pathway enhances its effects on RB1-intact K-Ras mutated lung and colon cancers. CDK4/6 inhibitors have potential to treat various RB1-intact cancers when combined with an appropriate kinase inhibitor.

Using data from 1,107 patients dating back over 30 years, researchers have connected prognostic impact to poorly differentiated tumor size in hepatocellular carcinoma. Data confirmed previous findings that after resection, <2 cm sized tumors had excellent long-term outcomes. However, ≥2 cm and ≥5 cm sizes shared a risk of early recurrence with the latter size also at risk of early extrahepatic recurrence.

The COVID-19 pandemic has increased attention on links between public health and the planet’s health — areas traditionally addressed in separate science and policy circles. Now, an international research collaboration conducted the first comprehensive review of urban climate change responses and potential human health improvements.

Researchers at Kanazawa University describe in Scientific Reports the identification of small compounds that can regulate the cellular production of extracellular vesicles — nanocontainers transporting biomolecules between cells. Such compounds hold promise for use in therapies for various diseases.

A rapid way to track an elusive part of the immune system will bring better vaccine strategies

KAIST researchers have used whole-genome sequencing to track the development from a single fertilized-egg to a human body.

Speakers announced for the 10th edition of IPI’s premier technology matching event

Distinguished Professor Reiko Kishi of the Hokkaido University Center for Environmental and Health Sciences was honored with the International Society for Environmental Epidemiology (ISEE)’s prestigious 2021 John Goldsmith Award, on August 26, 2021.

A novel CT scan-based approach has revealed significant changes in a parameter indicating lung destruction in some asthmatics. This finding could lead to more personalized treatments for asthma accompanied by persistent airflow limitation.

Sjögren's syndrome is an autoimmune disease that attacks the tear duct and salivary glands, leading to patients suffering unbearable dry eyes and mouth. To date, treatment options have been limited. But this may change thanks to a recently developed mouse model that will help explain the pathogenic mechanisms behind the disease.

The finding could underpin a “dream” vaccine that covers not only SARS-CoV-2 and its known variants of concern (VOCs), but also future VOCs and other animal coronaviruses with known potential to cause severe disease in humans

Through a follow-up analysis of d-ROM values taken pre- and post-cardiopulmonary exercise tests, researchers have found that heart failure patients with increased oxidative stress during exercise have a poorer prognosis - leading to potential design of exercise routines around individual patients.

Cells translate their genetic material at rapid rates with exquisite precision to reproduce, repair damage or even combat disease. But the process can deregulate and give rise to disease. Byproducts of errant processes can build up like gunk in the gears, especially around neurons, breaking down the repair mechanisms and causing further damage and even neurodegenerative disorders such as Alzheimer’s disease.

The nutritional status of children under five in Sri Lanka has not shown a significant improvement for the last 20 years. It has also been lagging behind most of the other health and social indicators on children. IPS research shows that household income, inadequate nutrient intake, breastfeeding practices, mothers’ education, etc., play a major role in child undernutrition in Sri Lanka. Moreover, given significant losses in household income experienced at the hands of the COVID-19 pandemic, nutrient intake may have declined further over the past year. As such, it would be a challenging task for health planners to develop effective strategies to minimise undernutrition among children under five years. This article highlights some of the facts contributing to child undernutrition in Sri Lanka and suggests ways to address this critical issue.

Researchers discover a link between an increase in protein Ba of the complement immune system and the eventual development of thrombotic microangiopathy in patients who have received an allogeneic hematopoietic stem cell transplantation.

An injection made of a hydrogel containing stem cells could treat damaged tissue following a heart attack.

People with autism spectrum disorder interpret facial expressions differently. A group of Tohoku University researchers have revealed more about how this comes to be. They induced abnormalities into a neural network model to explore the effects on the brain’s learning development.

Testing a large library of compounds reveals an easy-to-make lipid that can carry genetic code into the lung to treat disease.

Researchers have shown that postpartum depression can inhibit a mother’s ability to instill healthy tooth brushing habits in children. The study demonstrates the need to foster greater mental support and management for mothers and incorporate these factors when assessing children’s oral health.