Medicine & Healthcare

Analysis of more than 80,000 diabetes patients in Singapore links elevated systolic pressure and very low diastolic pressure to higher cardiovascular mortality. Underscores need to control high systolic levels while exercising caution with low diastolic levels.

New insights on how individual immune responses to the SARS-CoV-2 virus, particularly in mutant strains, can influence the efficacy of COVID-19 vaccines

The School of Chinese Medicine at Hong Kong Baptist University (HKBU) found that 55% of the patients who sought medical treatment from the “HKBU Chinese Medicine Telemedicine Centre Against COVID-19” during the fifth wave of the COVID-19 pandemic continued to experience at least one long COVID symptom for six months to a year after diagnosed with an infection. The most common symptoms are fatigue, brain fog and cough.

A research led by Hong Kong Baptist University (HKBU) has discovered that hyodeoxycholic acid (HDCA), a bile acid generated in human intestine, can reduce fat accumulation and inflammation in the liver, demonstrating its strong therapeutic potential for non-alcoholic fatty liver disease (NAFLD). The research also found that HDCA’s intervention in NAFLD works by reshaping the population of beneficial gut bacteria, which affects the metabolic interactions between the gut and the liver. The result highlighted the critical role of gut health in liver disease.

New shrimp species in ancient hot spring, Super sprouts, How "warm-ups" work, New antiviral candidate, Solving voltage decay and from our blog: A sustainable future shines in TIE 2023. Read all in the latest Editor's Choice.

Collaborations with seven key local partners aim to strengthen capabilities for integrated care for the “super-aged” society

A researcher from Osaka University has investigated the associations between mask usage and the reasons people give for wearing a mask. Online surveys were conducted before and after policies that downgraded the status of COVID-19. The study found that 59% of respondents continued wearing masks even after policy changes. Several sociological and psychological reasons other than disease prevention for mask usage were identified.

Research from Osaka University demonstrates a nanopore-based technique that can detect different variants of SARS-CoV-2, the virus that causes COVID-19. The method was very effective in detecting the Omicron variant of the virus in the saliva of people with COVID-19.

A broad-spectrum antiviral drug candidate, 2-thiouridine, that targets positive-strand RNA viruses has been identified and characterized.

New perspective argues pursuing fair AI for healthcare requires cross-disciplinary collaboration to translate methods into real-world benefits.

Researchers from Osaka University developed a cell-friendly means of bioprinting at high fidelity. By successive injection of a cell-based ink and a printing support, the ink solidified into defined geometries, even into the shape of a human nose. Printed cells remained viable for at least two weeks. This work is an important milestone toward developing lab-grown tissues and organs, and eventually advancing regenerative medicine as well as animal-free drug safety testing.

A research team led by Osaka University developed a theranostics approach to both diagnose and treat certain pancreatic cancer cases. They radioactively labeled a monoclonal antibody targeting glypican-1, which is highly expressed in pancreatic cancer, then administered it to disease model mice. One label, 89Zr, showed high uptake in tumors, which would allow early detection of pancreatic cancer with PET scans. Another label, 211At, was used with alpha therapy to significantly slow tumor growth.

Chemotherapy for cancer treatment often results in collateral damage to healthy cells and other adverse effects. A research team led by City University of Hong Kong (CityU) recently developed “sono-sensitised chemotherapy” (SSCT), a new form of ultrasound-activated chemotherapy, which further enhances the precision for eradicating deeper tumours with centimetre range of tissue penetration and minimises side effects.

The International Symposium on Triglyceride/Neutral Lipid and Rare Diseases will be held at the Kyoto International Conference Center on October 21 and 22, 2023. The symposium is organized by the International Symposium on Triglyceride/Neutral Lipid and Rare Diseases Conference Committee, which is led by Dr. Ken-ichi Hirano (Graduate School of Medicine, Osaka University) and the Japan Intractable Diseases (Nanbyo) Research Foundation.

Asia’s premier technology-matching platform returns for its 11th edition from 31 October to 2 November at Marina Bay Sands.

Osaka Metropolitan University researchers have used the power of laser light to accelerate the reaction between cancer cell-derived extracellular vesicles—a kind of nanoparticle—and antibody-modified microparticles. The three-dimensional structure of the resulting aggregates was then analyzed using a confocal optical system. The results demonstrated the ability to measure, within 5 minutes, approximately 1,000 to 10,000 nanoscale EVs contained in a 500 nL sample.

Hunting for supermassive black holes, Coastal survival at risk, Calcium and dead cell clean-up, Two naps are better than one & Pineapple leaf prosthetics. Read all in the latest Editor's Choice.

The researchers from Osaka University showed how two psychological factors, belief in just deserts (BJD) and human rights restrictions (HRR), differ across countries. BJD tended to be higher in Japan and lower in the UK, whereas HRR was higher in China and lower in Japan. Public health messages for high-HRR individuals could potentially be used effectively to reduce disease-related discrimination and prejudice.

A reanalysis of studies on night shift naps reveals the ideal snoozing schedule that may help combat fatigue and drowsiness when staying up all night.

Researchers at Osaka Metropolitan University have developed a measurement technique that rapidly measures the number of viable bacteria in food products. They have succeeded in drastically reducing the inspection time from 2 days to about 1 hour. With this technology, it will be possible to confirm food safety before shipment from factories and prevent food poisoning.

AXL and EGFR inhibitors combined hold promise in fighting certain head, neck, and lung cancers

Patients with a specific form of chronic indigestion react differently to images of food, compared to healthy control subjects or patients with irritable bowel syndrome.

In this collaborative project between Newcastle University and Universiti Malaysia Perlis (UniMAP), the team aimed to create a sustainable, cost-effective lower limb prosthetic socket (LLPS) using natural fiber-reinforced composites. The objectives included designing a green LLPS, assessing its environmental impact, and engaging stakeholders. PALF was selected as a sustainable reinforcement and incorporated into the composite. The design was guided by a static-friction (‘stiction’) load-transfer framework, developed previously by Goh and co-workers, which explains how force is transferred from the polymer to the fibres. The project has also inspired worldwide interest in sustainable LLPS development through a press release, receiving inquiries from students at Nanyang Technological University in Singapore and a group of 7th graders in the USA.

Capturing carbon dioxide, Shells go nuclear, Worms surf electric fields, Brain repair & Creating matter from light. Plus from our blog: Monitoring research for further impact. Read all in the latest Editor's Choice.

Researchers at Kanazawa University report in Cell Reports how alterations in the nuclear pores lead to the degradation of anti-tumor proteins.

In recent years, an emerging zoonotic pathogen called E. albertii, transmitted by wild animals such as raccoons, has garnered attention due to its remarkable similarities to several strains of Escherichia coli (E. coli), including O157, and its potential to cause severe illness, particularly in children. A research group at Osaka Metropolitan University has developed a novel culture medium that allows for the selective cultivation of E. albertii from raccoon fecal samples. This enabled the successful isolation of E. albertii even from samples with very low quantities of this bacterium. Their findings are expected to further elucidate the bacteriological characteristics of E. albertii and to contribute to the control of foodborne illnesses.

Researchers from Osaka University have revealed that the expression of a specific isoform of GREB1 Is4 is induced in malignant melanoma cells by the melanocyte-specific transcription factor, MITF. They revealed that GREB1 Is4 stimulates pyrimidine biosynthesis and promotes cancer cell proliferation. Furthermore, the anti-tumor effect of antisense nucleic acids against GREB1 showed a potential new modality for malignant melanoma.

How much is adequate screen time for a child? It is the question at the forefront of many parents’ minds. Now, a recent cohort study has found that the amount of screen time spent by one-year-olds is associated with developmental delays.

It is the first local research and innovation platform enabling Primary Care Professionals from public and private healthcare to deliver stronger primary care and improve patients’ health outcomes

Osaka Metropolitan University scientists have verified the anticancer effects of Kencur, a tropical plant of the ginger family, mainly grown in Southeast Asia, in cell and animal experiments. They found that Kencur extract and its main active components significantly inhibit cancer cell growth at the cellular and animal levels. Furthermore, the involvement of TFAM in the mechanism of action was confirmed.