Medicine & Healthcare

Researchers from Osaka University found that a new activator called L687 induces cancer cells to accept delivery of antisense oligonucleotide (ASO) drugs. These drugs can treat cancer by blocking the transfer of messages from genes that encourage cancer growth. Previous methods to deliver ASOs into cells had only limited success. This research will help accelerate the development and delivery of novel ASO cancer therapies.

A recent study by Tohoku University researchers has shed light on the association between dairy product consumption and odd-number carbon chain fatty acids (odd-FA) within the Japanese population, a correlation previously confirmed in Europe and Oceania but understudied in Asian countries.

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Researchers from Japan’s Osaka University and Switzerland’s University of Lausanne explored the ethical considerations and current status of cancer multigene panel testing access in their countries. Despite cultural and healthcare differences, they found common national barriers: limited test availability, insufficient patient information, and variable insurance coverage. The study underscores the need for more equitable genetic medicine, suggesting improvements in test access, patient education, and insurance policies.

New research could pave the way to develop cancer drugs targeting an enzyme that inhibits ferroptosis, a type of cell death. Cancer cells that are resistant to anticancer drugs are known to be vulnerable to ferroptosis. Therefore, agents that effectively induce or enhance the sensitivity of cancer cells to ferroptosis are expected to become novel anticancer agents.

Rapid, responsive, and readily-available antigen-antibody testing is crucial in the fight against infectious diseases, something driven home by the COVID-19 pandemic. To improve these tests, a Tohoku University research group has created a new method to form polymer particles that are adorned with gold nanoparticles.

Researchers from Osaka University found that exposure to environmental carcinogens and psychological distress significantly decreases happy life expectancy, a measure of the lifespan during which an individual experiences subjective emotional wellbeing. These findings suggest that developing public health policies to reduce exposure to these chemicals could help people live longer, happier lives.

Researchers from Monash University and Osaka University have unveiled a groundbreaking discovery regarding the pivotal role of sensory neurons in orchestrating tissue repair and regeneration, offering significant promise for patients with poorly healing tissues and diabetes.

Numerical basis found for picosecond laser endpoints in effective clinical treatments with fewer complications

Scientists from Duke-NUS Medical School have identified a gene that plays a crucial role in regulating energy supply to cells that drive kidney failure. This discovery concerning the gene, named WWP2, offers a new target for therapies aimed at mitigating kidney scarring and damage.

Two rare skin conditions with similar symptoms can be mistaken for each other, so a scoring system has been formulated to aid physicians in distinguishing two diseases

Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are neurodegenerative diseases that commonly occur in middle-aged people. FTD is second only to Alzheimer's disease in terms of dementia prevalence. Both ALS and FTD arise from neuronal degeneration through mechanisms that remain unclear. Dr. Yun-Ru (Ruby) Chen's team in the Genomics Research Center (GRC), Academia Sinica recently discovered a new pathological mechanism for neuronal degeneration using synthetic peptides. They also discovered that a disaccharide can increase neuronal survival and reduce degeneration. The result provides therapeutic strategies for future treatment of these neurodegenerative diseases. The study was published in the top international journal "Science Advances" on February 23, 2024.

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Peptides are short strands of amino acids that are increasingly used therapeutically, as biomaterials and as chemical and biological probes. The capacity to isolate, manipulate and label peptides and larger proteins is limited, however, by the ability to reliably attach functional molecules, such as fluorescent compounds, to peptides in locations that won’t affect the three-dimensional structure and function of the short amino acid strand. Researchers have developed a unique chemical reaction to attach two distinct functional molecules to the N-terminus of a peptide in an efficient, robust reaction under mild conditions.

Magnetic nanorobots delivering nerve cells to targeted tissues could potentially be used to repair damaged brain tissue, as well as other organs.

MozzHub, a user-friendly dengue hotspot detector, could significantly assist the management and control of dengue.

research team from Tohoku University Graduate School of Medicine undertook a detailed examination of the medical validity of deep learning models using post-mortem imaging for diagnosing drowning. The results reveal an inconsistency between the deep learning models’ results and the medical professionals’ observations.

Regenerative therapy to treat heart failure is more effective when the mitochondria of the regenerative cells are activated prior to treatment.

Researchers at Osaka Metropolitan University assess why post-operative symptoms such as pins and needles, sudden cold, burning, itching, and numbness in the limbs remain in patients suffering from cervical spondylotic myelopathy, even after surgery. The researchers also evaluated the patients’ satisfaction with postoperative treatment. They found that it was lower for those who still had paresthesia in their hands and feet, regardless of whether their motor symptoms had improved or not.

In a step forward for breast cancer treatment, researchers at Tohoku University have developed a novel monoclonal antibody which specifically targets a certain type of breast cancer cell.

Vaccines and therapies based on messenger RNA could be more readily delivered due to a non-toxic polymer that protects RNA and controls its release inside cells.

A new coating for tiny vaccine carriers allows vaccines to remain in the body for longer.

A team of researchers from Osaka Metropolitan University assessed the feasibility of conducting cardiopulmonary exercise testing with the upper limbs as an alternative to the conventional method that uses the lower limbs. The researchers investigated the relationship between heart rate and oxygen uptake during exercise stress tests using a cycle ergometer and an arm crank ergometer, and estimated maximal oxygen uptake. The study participants were 17 male collegiate athletes from rowing and cycling clubs. The results showed that the estimated maximal oxygen uptake for both rowing and cycling groups was lower on the arm crank ergometer than on the cycle ergometer. Additionally, this study showed that exercise testing using an upper extremity ergometer underestimates cardiopulmonary function, regardless of upper limb training status.

Elucidating why some patients with specific joint deformities are symptomatic while others are not

The estate of the late Ms Diana Koh gifted S$1M to Duke-NUS Medical School and NUS Medicine to fund young cancer researchers and raise awareness about cancer research advances. The gift establishes research funds, grants, prizes, and learning series to support innovative approaches to cancer treatment by the next generation of scientists and clinicians.

A new technology to increase visibility of cancer cells to the immune system using CRISPR has been developed, and could lead to a new way to treat cancer.

- DGIST Prof. Kim Sohee and team develop soft, flexible, and highly durable brain electrode technology. - Expected to be used in brain-machine interfaces without causing tissue damage, and to treat brain diseases.

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Much is known about the added complication to pregnancy when it comes to the age of the mother, but recent studies show that the age of the father can also heighten the risk of neurodevelopmental disorders. A team of researchers has explored the impacts of paternal aging on microRNAs, the molecules that play a crucial role in regulating gene expression.

Tohoku University researchers have unveiled a new approach to treating lymph node metastasis. The process invovled administering anticancer drugs directly into the lymph nodes, producing better outcomes and lessening the side effects commonly associated with cancer treatment.