Medicine & Healthcare

Scientists have identified a series of molecular candidates for those parts of dog allergens that cause immune reactions in people—the first step in developing a vaccine against most causes of dog allergies.

We have succeeded in establishing a mouse model that develops gastric cancer closely resembling advanced human gastric cancer. Using this model, we have discovered gastric cancer stem cells, i.e. Lgr5+ gastric cancer cells, essential for the development, maintenance, and metastasis of cancer. Our study provides an experimental system that enables detailed analysis of highly malignant gastric cancer and is expected to lead to the development of a breakthrough treatment for advanced human gastric cancer.

In a study of 280 patients who underwent transcatheter aortic valve replacement (TAVI), researchers investigated the 3-year prognostic impact of frailty evaluated by the Kihon checklist (KCL), a survey originally developed to identify elderly individuals who were at risk of requiring support within the Japanese long-term care insurance system. Results showed that the estimated 3-year mortality rate was significantly higher in individuals who ranked high on the KCL, showcasing the checklist as a simple tool to be used alongside other surgical risk scores, in identifying patients who are too frail to benefit from TAVI

In a recent study published in the Journal of Extracellular Vesicles researchers from Kanazawa University have visualized structural changes on the surface of SARS-CoV-2 that enable it to enter human cells.

A prototype MRI machine that can be built at low cost and produces high quality neuroimaging is reported in Nature Communications. The machine can help provide access to MRI across low- and middle-income countries, as well as at the point of care.

Micro-plastics cross blood brain barrier, Stomach cancer atlas, Omicron variant isolated, 120-year-old reaction turned on its head and Reporting through the coup, all in the December Editor's Choice. Plus our latest podcast: Decentralization and Democracy in Myanmar.

Scientists at Hokkaido University and Texas A&M University have identified a key mechanism used by the SARS-CoV-2 virus to evade host immune systems.

Examination of Japanese cases of gynecological cancer offers a better understanding of the profile of a rare ovarian tumor and could change treatment guidelines.

Giants in History: Esther Park (1877-1910), born Kim Jeom-dong, was the first female Korean physician to practise modern medicine in Korea.

Researchers at the Department of Microbiology at The University of Hong Kong have succeeded in the isolation of SARS-CoV-2 Omicron variant from clinical specimens. This is the first known research team in Asia that has succeeded in isolating the Omicron variant. The isolated variant will enable the development and production of vaccines against Omicron, which has been designated as a "variant of concern" by the World Health Organization.

Researchers from the Osaka City University Graduate School of Medicine have shown in patients with early-stage hepatocellular carcinoma who received cancer treatment that eliminating the hepatitis C virus with a direct-acting antiviral treatment reduces the risk of the liver cancer progression and increases overall patient survival.

Scientists are turning to genomics to better understand the epidemiology of malaria and to inform control and elimination interventions and strategies. In the Lake Victoria region of Kenya, malaria burden remains very high despite more than a decade of intense control activities. A team of researchers from Osaka City University, Nagasaki University, London School of Hygiene and Tropical Medicine, and Mount Kenya University generated whole Plasmodium falciparum genome sequences from the lake region. Their analyses revealed that malaria parasites from this region appear distinct from other parasites from East Africa, while frequencies of known drug resistance markers were similar to those in other East African parasite populations. Their findings will help to develop improved surveillance tools to determine parasite transmission routes and aid clinical disease management.

Giants in History: A Japanese surgeon, Tetsuzo Akutsu (20 August 1922 – 9 August 2007) built the first artificial heart capable of keeping an animal alive.

We have clarified at the molecular level the mechanism by which a microenvironment, a so-called niche that surrounds cancer cells, is formed in which stromal cells and immune cells are attracted at an initiation stage of breast cancer onset. A molecule called FRS2β is found to be critical for creating this microenvironment. The present finding is expected to be beneficial in prevention, diagnosis and treatment of cancers at the initiation stage.

Malfunctioning of the so-called Hippo signalling pathway within animal cells leads to irregular activity of proteins that regulate genes involved in cell proliferation. Researchers have identified a key step in the process of this aberration, opening the door to new therapeutics for cancers such as head-and-neck squamous cell carcinoma and lung adenocarcinoma.

The world’s largest analysis of gastric tumour cells provides a launch pad for scientists to plan more effective therapies.

The new radiosensitivity biomarker can make way for chemoradiotherapy treatments tailored to each cancer patient in the future.

A collaborative project between the Osaka City University Graduate Schools of Medicine and BioMedical Engineering Center (BMEC) revealed new bone formation in critical bone defects of animal model with an exposure to a pencil-type non-thermal atmospheric-pressure plasma at surgery.

Researchers reveal correlation between ribotype (RT) strains of Cutibacterium acnes, which are found in human skin, and the lifespan of the nematode Caenorhabditis elegans. Strains RT4 and 8, which are associated with acne in human skin, shortened the lifespan of the nematode, while RT6, which are predominantly found in healthy human skin, did not. Also, it was found that the healthy skin-related RT6 strain of C. acnes improved C. elegans resistance to the pathogenic organism Staphylococcus aureus.

Researchers have revealed in an animal model that ImmuBalance, a fermented soybean product, is effective in suppressing airway inflammation caused by asthma. Results showed a decreased presence of eosinophils in bronchoalveolar lavage fluid, a decrease in mucus production in the bronchial epithelium, and a suppression of proteins that induce eosinophilic inflammation.

Giants in History: Fe Villanueva del Mundo (27 November 1911 – 6 August 2011) was a Filipina paediatrician who founded the Philippines’ first paediatric hospital. She graduated top of her class at the University of the Philippines, and in 1936 became the first female student to attend Harvard Medical School.

Giants in History: Tsai-Fan Yu (1911 – 2 March 2007) was a Chinese-American physician and researcher who was the first female full professor at Mount Sinai School of Medicine.

The El Niño Southern Oscillation (ENSO) could impact child nutrition in many countries in the tropics, a new study in Nature Communications suggests.

New drug formulations aim to improve the in vivo circulation of Xylonix’s novel immunotherapies for treating both cancer and complications arising from COVID-19 infection.

Giants in History: Wu Lien-teh (10 March 1879 – 21 January 1960) was a Malaysian-born doctor who invented a mask that effectively suppressed disease transmission.

Researchers are empowering the elderly in Singapore to choose their preferred treatment option when diagnosed with end-stage kidney disease.

A previously unknown virus that can infect humans and cause disease has been identified by scientists in Japan. The novel infectious virus, named Yezo virus and transmitted by tick bites, causes a disease characterized by fever and a reduction in blood platelets and leucocytes.

Paris, 29 September — UNESCO and the L'Oréal Foundation are unveiling the winners of this year’s International Prize for Women in Science, which honours five eminent women scientists with exceptional careers from the five regions of the world, as it has done annually since 1998.

Geneva, 28 September 2021 – The Stop TB Partnership today released new data showing how the COVID-19 pandemic and dismally low levels of funding represent the main barriers to achieving the United Nations Sustainable Development Goals of ending TB by 2030.

Researchers conducted an online survey on nutrition, dietary behavior, and body image with 32 national and international level para-athletes with physical disabilities such as spinal cord injury or limb defect/amputation. Results showed that about 40% need assistance in procuring and cooking food and that it is difficult to achieve their ideal diet on their own. Also, although para-athletes with a good body image rated their eating habits as healthy, they had a low percentage of correct answers to questions about nutrition.