Medicine & Healthcare

An Osaka University study investigated how the COVID-19 onset and media coverage affected hand hygiene compliance. Voluntary use of hand sanitizer in a hospital rose from 5% in December 2019 to 70%+ by August 2020. In the same period, TV coverage reached 7.7 hours/day on a national broadcaster. The study’s simulations found a significant relation between TV coverage and hand hygiene compliance, though no correlation between compliance and newly confirmed COVID-19 cases and deaths.

Atopic dermatitis skin lesions and the lesions produced by infectious complications of the disease look so similar that it makes it impossible for patients to spot the difference and know when to visit their doctor for treatment. But an AI-powered mobile app developed by dermatologists now puts the power of diagnosis in the hands of patients.

Tohoku University researchers have discovered that softer gums hinder the development of gingiva fibroblasts – the cells that help produce the fibers that hold our teeth in place.

Cancer metastasis is a major cause of cancer-related death. A research team at City University of Hong Kong (CityU) recently identified a protein that triggers the migration of liver and pancreatic cancer cells and metastasis, and is correlated with shortening the survival time of patients. The research findings were verified by in vitro and in vivo models, supported with clinical data, and are expected to provide a new potential target for cancer therapy.

Asia Research News met five female researchers to learn about their research, what drew them to Kavli IPMU, and their experiences there. These women, from diverse backgrounds, excel in their fields and show what can be achieved when women are not held back.

Researchers in Sarawak, Malaysia, measured the immunity responses of people who received different COVID-19 vaccines.

Researchers are working to overcome challenges in order to bring wearable, electric, wound-healing devices to clinical practice.

Lipid nanoparticles have been used to encapsulate CRISPR-Cas9 and deliver it to cells in mice, where it was highly effective at knocking down expression of a target protein.

Brain shrinkage patterns tied to low trust have links to depression vulnerability that can alert to its early detection even before symptoms appear.

A new apparatus uses electromagnets to remotely control guidewires through tiny, tortuous blood vessels for the treatment of cardiovascular diseases.

A research group from the Osaka Metropolitan University Graduate School of Medicine conducted a survey of 285 patients regarding the long-term aftereffects of COVID-19. As a result, they revealed that more than half of COVID-19 patients still had residual symptoms, even close to a year afterward. It became clear that fatigue, abnormalities in senses of taste and smell, hair loss, and sleep disorders could persist, regardless of the severity of the initial COVID-19.

This year’s roster is the third cohort to be inducted into the Hall of Master Academic Clinicians, an honour conferred on exceptional clinician-educators at the SingHealth Duke-NUS Academic Medical Centre.

Tree rings forecast extreme weather in central Asia, Squid 🦑and chemistry make versatile hydrogels, James Webb telescope reveals the earliest galaxies & Reducing negative effects of screen time. Read all in the latest Editor's Choice. Plus our latest journalist resource "Experts for Media: Antimicrobial Resistance "🦠.

Antimicrobial resistance is a global public health threat. Asia Research News has prepared a resource for journalists to find stories and connect with scientists combating antimicrobial resistance.

A new approach that ‘baits’ the caps or telomeres protecting the ends of chromosomes could provide information on how rapidly we are ageing and what we need to do to slow it down.

Team studies discrimination, mental distress, and work impairment in COVID-19 survivors.

Researchers from Osaka University have shown sex-specific differences in the immune response to COVID-19 infection. By identifying and analyzing the immune cell population in COVID-19 patients, they showed that infection results in a reduced ratio of circulating follicular T regulatory (cTfr) cells to a network of antibody-producing proteins, correlated with dysregulated antibody production. This cTfr cell reduction is more significant in males, providing cellular evidence for the observed association between increased risk and male sex.

Hokkaido University researchers have developed a novel method to design and develop peptide antibiotics in large numbers, which will prove critical to controlling antibiotic resistance.

Researchers from Osaka University have used single carbon atom doping to form four chemical bonds in one step. Gamma-lactams (cyclic molecules that are common in antibiotics) were easily synthetically accessible from alpha, beta-unsaturated amides (an important molecule in cancer progression). The team chemically modified an anti-seizure medication in 96% yield, highlighting the work's utility to otherwise synthetically complex aspects of pharmaceutical development. The results of this work could become foundational to drug discovery and development.

Blocking an immune-regulating protein reverses the damage caused by acute and chronic kidney disease, a preclinical study suggests.

A new microscopic technique allows for the real-time study of RNA G-quadruplexes in living cells, with implications for the fight against amyotrophic lateral sclerosis.

Researchers from Osaka University compared the sensitivity of rapid antigen tests (RATs) and polymerase chain reaction (PCR) tests for the Omicron variant of COVID-19 using data produced by the Japan Professional Football League. They found the comparative sensitivity of RATs for Omicron was not affected by the duration from the onset of symptoms to testing.

New research found that periodontitis, a common gum infection known to worsen other systemic diseases, could also be linked to atrial fibrosis — potentially clarifying its previously unknown connection with atrial fibrillation.

New research from Osaka University indicates that more screen time at age 2 is associated with poorer communication and daily living skills at age 4—but when kids also play outdoors, some of the negative effects of screen time are reduced. Increasing outdoor play time could reduce the negative effects of screen time on daily living skills by almost 20%.

Overeating mechanism: why "eating just one chip"🍟 is impossible, Measuring hidden energy of gamma-ray bursts, Marine species that can adapt to ocean acidification & A rough start can lead to a strong bond, Read all in our first Editor's Choice of 2023. Plus our interview on what dengue vaccine approval in EU💉means for global dengue protection.

In a study recently published in Cancer Science researchers from Kanazawa University show how some intestinal cancer cells lose their ability to spread as they divide and can be eliminated as the cancer grows.

Researchers led by Osaka University demonstrated the role of endothelial cell-specific protein Roundabout4 (Robo4) in the reduction of vascular permeability and mortality in mouse models of severe infection. The research team identified a drug inhibitor that increased Robo4 expression and reduced mortality in sepsis and SARS-CoV-2 mouse models of infection. These findings may aid in the development of drugs to reduce the mortality rate of severe infectious diseases.

An Osaka Metropolitan University research group recorded the autonomic nervous system activity in patients with irritable bowel syndrome (IBS) and healthy subjects using a wearable device and a proprietary smartphone application to record daily life events such as defecation and sleep. As a result, they found that sympathetic nervous system activity was activated in IBS patients from 2 minutes before defecation and continued until 9 minutes after defecation. Further research is expected to improve the quality of life of IBS patients and elucidate the pathophysiology.

Osaka Metropolitan University scientists delved into the relationship between gait function and knee extension velocity after total knee arthroplasty and compared the effects of various factors on walking. The results reveal that knee extension velocity, measured while seated, on the operated side was the most important determinant of gait function. These findings are expected to contribute to the development of new rehabilitation programs for efficient gait function improvement.

Researchers at Hokkaido University have revealed the effects of high pathogenicity avian influenza virus infection on an Ezo red fox and a Japanese raccoon dog, linking their infection to a recorded die-off of crows.