Medicine & Healthcare

Carbohydrates affect weight gain and metabolic energy

By conducting the world’s first randomized clinical trial, researchers have demonstrated that, while overall survival rates remained comparable in this initial phase, TEE-guided precision CPR enhances end-tidal CO2 levels (indicating better CPR quality and forward blood flow), transforming traditional "blind" compressions into a data-driven science. This groundbreaking research published in JAMA Internal Medicine paves the way for individually customized resuscitation—challenging global standards to maximize survival for millions worldwide.

Stem cell transplantation could be a rapid and effective way to restore haemoglobin production in individuals with the blood disorder β-thalassaemia, which affects more than 40,000 children annually worldwide.

AI-driven tests jointly developed by Singapore Eye Research Institute (SERI) and Duke-NUS capture patients’ quality of life in minutes, helping doctors and researchers make faster, better-informed decisions.

Assessing the toll of elongated working hours in community-dwelling, middle-aged adults

Researchers have mapped how genetic switches are regulated in East Asian populations, identifying tens of thousands of unique markers linked to complex diseases. This massive dataset bridges a crucial diversity gap in genetics, paving the way for more inclusive translation of genetic discovery worldwide.

A mitochondrial enzyme, Ak4, strengthens immune defense by promoting mitochondrial DNA synthesis and enhancing macrophage antibacterial activity.

Natural experiment along new railway reveals unexpected correlation between location and healthcare costs

A collaborative research group has shown that biological neurons can be trained to perform a temporal pattern learning task that was previously carried out by artificial systems

Researchers at Tohoku University have imagined a future where you can assess eye health at a local supermarket, train station, or in remote regions without hospital access using a portable, inexpensive eye scanner.

Hiroshima University researchers have developed a practical framework to identify candidate pathogenic variants hidden among the large number of variants of uncertain significance (VUS) detected in comprehensive genomic profiling (CGP) of cancers. This framework could improve the accuracy of precision oncology by more reliable prioritization of VUS.

A poor diet remains a leading contributor to ischaemic heart disease, according to an analysis from 204 countries over a 30-year period

Researchers develop a system that inflates human lung organoids from within to analyze lung mechanics

A new global review shows countries taking very different approaches to regulating polygenic embryo testing

National Taiwan University researchers have engineered a dual-targeting nanocarrier that safely sneaks potent chemotherapy past the blood-brain barrier. By homing in on a specific protein (FAP) expressed by both the glioblastoma cells and their protective “helper” cells, this approach directly shrinks the deadly tumor while reprogramming the immune system to join the fight.

Researchers from The University of Osaka found that leukemia caused by NUTM1 rearrangements is distinguished from other forms of B-cell acute lymphoblastic leukemia (B-ALL) by a unique pattern of gene activity and gene regulation. Unlike the common form of B-ALL caused by KMT2A rearrangement, which is resistant to treatment, leukemic cells with NUTM1 rearrangements are highly sensitivity to chemotherapy.

A research team at National Taiwan University found that abnormal blood flow activates CB1 receptors in endothelial cells, promoting vascular inflammation and dysfunction. Soy-derived isoflavone prodrugs that inhibit CB1 may help protect blood vessels and prevent atherosclerosis.

Researchers from The University of Osaka studying simple cyanobacteria found that one protein keeps their internal clock ticking reliably, even outside a living cell. By testing over 20 variants with clock periods ranging from 15 to 60 hours, they discovered that timekeeping precision appears to be built directly into the protein itself, independent of cell activity or environmental changes.

Scientists discovered a natural “brake” protein in immune cells that stops harmful overreactions during serious infections. When this brake is missing, the body’s defense cells go out of control and damage organs, but restoring it could open the door to better treatments for life-threatening sepsis.

This study shows that MFSD2A transports key lipids (fat molecules) from the blood into the skin, a process critical for maintaining a healthy skin barrier.

We identified Mrep macrophages that repair muscle but trigger heterotopic ossification in FOP, advancing muscle and FOP therapy development.

Through protein binding, molecular heavy drugs are effectively transported to cancerous tissues

A Taiwan-oriented study in Gut shows that gastric cancer is shaped by complex interactions between environmental exposure, microbes, host, and tumor biology. The findings reveal distinct cancer routes and targets linked to prognosis and potential treatment opportunities.

The famed Japanese green tea powder may suppress nerve activity associated with sneezing in hay fever, according to a study in mice.

Changes in male hormones and excessive sugar intake work together in progressing liver damage

Researchers at the Cancer Research Institute and the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, have uncovered a critical mechanism that enables gastric cancer to spread to distant organs. Their study shows that cancer cells stimulate Wnt signaling in surrounding stromal fibroblasts to produce hyaluronan, creating a supportive microenvironment that promotes metastasis. These findings provide new insight into how metastatic tumors establish themselves and suggest promising strategies to prevent gastric cancer progression.

HBsAg seroconversion, durable HBsAg loss, and the presence of anti-HBs are considered indicators of an almost complete cure of chronic HBV infection, which is viewed as a goal that is rarely achieved with current antiviral treatments. Researchers from the College of Medicine of National Taiwan University and National Taiwan University Children’s Hospital identified that the undetectable circulating HBV RNA after HBeAg-seroconversion is an important predictor of HBsAg seroconversion.

Kelli canines, Healthy fats in rice, Mercury and Earth in chorus, AI lights up materials discovery, Radiation detection with phones and Down to one. Read all in the latest Editor's Choice. Plus Women's Month 2026.

A team of researchers from Taiwan has developed PanMETAI, an AI-powered platform that analyses metabolic fingerprints in a simple blood sample to detect pancreatic cancer at its earliest stages—when treatment is most effective—achieving up to 94% diagnostic accuracy.

Researchers from The University of Osaka have found that potassium KCNQ2/3 channels in the brain, which are important for suppressing cell excitability, need to be fully functional to be trafficked to the appropriate part within the nerve cell and work properly. This link between channel functionality and localization may have important consequences for the development of therapies against KCNQ2/3-related epilepsy.