Nature Communications

An international team of researchers has studied the heterostructures of layered antiferromagnets, painting a better picture of what happens when two different magnetic orders are combined.

Silencing the gene, called WWP2, in patients in the early stages of cardiomyopathy could delay progression to heart failure by controlling immune cell infiltration and activation, and halting the formation of excessive scar tissue, preclinical data suggest.

Quinine and various drugs based on its chemical structure have been used to treat malaria for centuries. But parasites resistant to antimalarial drugs are becoming apparent. To pave the way for future medicine development, an efficient way to synthesize quinine was needed. And now a research team from Tohoku University has achieved just that.

First-in-the-world high-resolution imaging allows scientists to study the dengue protein in greater detail to yield valuable insights.

We don’t know much about the Earth’s inner core because recreating its conditions in a laboratory setting remains fraught with difficulties. Based on tracking seismic waves, scientists theorize that the area in and around the core comprises mostly of iron. But the values extracted from these indicators differ from how pure iron typically behaves. Now, a collaborative research group has succeeded, for the first time, in measuring the speed of sound of pure iron under pressures similar to the Earth’s inner core boundary.

Most metal and alloys possess a high elastic strain rate at the micro level. But this changes when they are in their bulk shape, as they are for everyday engineering applications. Now, a research group has developed a bulk copper-based alloy boasting the largest tensile elastic strain at room temperature to date.

Theory-guided development of an easier, more versatile process for synthesizing unsymmetric ligands provides new avenues of exploration in transitional metal catalysis.

Hydrogen, a clean fuel, is incredibly dense in energy—three times more than diesel or gasoline. Its ability to power a sustainable future has been hindered by a lack of high performing catalysts. Now, a collaborative research group has developed nanoporous molybdenum-based intermetallic compounds that could address this conundrum.

Researchers from Osaka University have developed a computational analysis tool called CAPITAL for comparative analysis of single-cell RNA sequencing data with complicated branching trajectories. As cells undergo a dynamic process, they can be placed on a “pseudotime trajectory” to analyze the gene expression changes throughout the process. While previously only straightforward linear trajectories could be compared, CAPITAL is proven to be able to accurately compare branching trajectories, significantly advancing the field of high-throughput single-cell sequencing.

Researchers from Osaka University have found that serum albumin interferes with β2m amyloid fibril formation through macromolecular crowding. Monitoring serum albumin concentrations could therefore help prevent patients from developing dialysis-related amyloidosis, a serious complication of long-term dialysis.

Researchers from Osaka University revealed that the surface electronic structure of topological insulators varies according to its surface atomic structure, even though it was believed to have been protected by the symmetry of the electronic structure inside the crystal and is therefore unaffected by differences in surface atomic structure. This work offers a new means of minimizing the power consumption and increasing the speed of next-generation technology.

- The low-cost, high-energy, long-life lithium-sulfur battery is based on a novel silica/sulfur interlayer. - The battery is expected to be used in next-generation mobile phones, drones, and electric vehicles owing to its high energy density and improved lifespan.

Hokkaido University researchers find a new way of producing the industrially important propylene that is more energy efficient than existing approaches—and in the process turns carbon dioxide into another usable resource. Their pioneering catalyst design thus contributes to the carbon neutralization of the petrochemical industry.

A pathway that malfunctions in advanced non-alcoholic fatty liver disease could be fixed with the aid of spermidine, a compound naturally found in bodily cells and certain whole foods.

The activity of deep-focus earthquakes, which increases with depths from ~400 km to a peak at ~600 km, is enigmatic because conventional brittle failure is unlikely to occur at elevated pressures. Our experiments showed that formation of thin weak layers filled with nano-crystalline olivine/wadsleyite, upon the pressure-induced phase transition of olivine, is the major cause of deep-focus earthquakes on the metastable olivine wedge in deep slabs.

Researchers develop a new integrated framework that factors in the many variables relevant to accurate carbon emissions modeling in the transportation sector, allowing for policymakers to choose the best path to achieve carbon neutrality.

Rare earth metals, when linked, can act as a conduit for energy flow, and show promise for the development of novel materials.

- Joint research team of DGIST Professor Um Ji-won and Professor Ko Jae-won discovered several SLITRK2 synaptic adhesion gene mutations related to intellectual disabilities - Identified the abnormal pattern in the signaling mechanism of SLITRK2 and presented a new therapeutic biomarker

Scientists from the Institute of Industrial Science, The University of Tokyo, demonstrate that accounting for liquid preordering is essential to predicting crystal growth

A team co-led by a City University of Hong Kong (CityU) neuroscientist has identified a key mechanism of a biological clock that ensures roundworms stay regular by defecating at steady intervals.

Innate immunity is activated when the pattern recognition receptors (PRRs) recognize pathogen-associated molecular patterns (PAMPs). We show that a liver-derived secretory protein LECT2, a hepatokine, binds to the HGF receptor MET, a proto-oncogene product, to suppress the proliferation signal of MET. LECT2 activates retinoic acid-inducible gene-I, enhancing antiviral and innate immune responses through MET. Thus, LECT2 is an anti-proliferative and immunoregulatory factor that could be a therapeutic target for viral infections and cancer.

Understanding the structural origin of the anomalous properties of SiO2 liquid and glass is of great interest in a wide range of scientific fields. The fraction of the S state with tetrahedral symmetry structure is considered to be the controlling parameter of the anomalous properties of SiO2 liquid in theoretical studies. However, it has not been well identified in experiments. In this work, we find experimental evidence of tetrahedral symmetry breaking in SiO2 glass under pressure.

Tetraphenylammonium, with all four hydrogens of ammonium (NH4+) replaced with benzene rings, has neither been discovered in nature nor chemically synthesized, calling into question whether it could exist. Here, we succeeded in synthesizing tetraphenylammonium for the first time, demonstrating its stable existence. The synthetic strategy used in this study, radical coupling, may be applicable to the synthesis of various related ammoniums with high structural novelty.

Structural color printing creates new pathways for medical diagnostics and miniaturized sensors

A Hong Kong Baptist University (HKBU) collaborative research study has revealed that certain gut microbial enzymes mediate the reactivation of triclosan (TCS) from its inactive glucuronide metabolite. TCS is an antimicrobial agent commonly used in a wide range of consumer products, and it is associated with the development of colitis.

Osaka City University* study suggests memories are formed through an integration across brain regions via burst activity in amygdala-prefrontal neuronal ensembles during memory acquisition, and then hippocampal-prefrontal synchrony during post-experience sleep. (Osaka City University has now changed its name as Osaka Metropolitan University)

Scientists have found a common substance that can reversibly and rapidly store and release relatively large amounts of low-grade heat without decomposing. The research could lead to more efficient reuse of industrial waste heat.

An analysis method for protein–protein interactions using proximity-dependent biotinylation for next-generation drugs

A prototype MRI machine that can be built at low cost and produces high quality neuroimaging is reported in Nature Communications. The machine can help provide access to MRI across low- and middle-income countries, as well as at the point of care.

Scientists at Hokkaido University and Texas A&M University have identified a key mechanism used by the SARS-CoV-2 virus to evade host immune systems.