Nature Communications

Researchers from Osaka University have identified key immune cells that respond to the COVID-19 mRNA vaccination. These cells, known as activated atypical B cells, are increased in blood samples from people who have been vaccinated against COVID-19. Additionally, people with higher levels of these cells have more antibodies to fight the COVID-19 virus. These findings should help researchers assess how well people respond to the vaccine and help improve the design of new vaccines.

A new fuel cell catalyst made from platinum and magnesium delivers exceptional efficiency and durability, potentially transforming clean energy technology.

- DGIST Professor Seo Byeong-Chan’s research team is the first in the world to discover how PAC channels work. - Their research has revealed a method to prevent cell edema and tissue damage, which may help treat cancer and brain diseases.

Researchers from Osaka University found that voltage-sensing phosphatase (VSP) is activated by electrical signals during sperm maturation and is crucial for establishing the optimal phosphoinositide environment to generate functional spermatozoa. Modulating VSP function to promote appropriate sperm maturation could be used to develop clinical treatments for infertility in the future.

A newly developed compound that reduces harmful inflammation in rats caused by overactive neutrophils shows great potential as a safer treatment for various inflammatory diseases in humans.

By putting theory into practice, Prof. Pi-Tai Chou’s research team has repeatedly broken the world record for NIR organic luminophores, overcoming the energy gap law. In 2017, we developed a material with an external quantum efficiency (EQE) of 24% at 740nm, followed by a molecule with an EQE of 10% at 800nm in 2018. In 2020 and 2022, through deuterium substitution, we successfully developed unprecedented OLEDs with an EQE of 4% at 1000nm. However, developing new cutting-edge materials is challenging. Alternatively, in terms of device engineering, we have been continuously exploring new techniques to further enhance efficiency using existing materials. This paper, published in Nature Communications (2024, 15 (1), 4664), marks the first time internationally that transfer technology has been successfully utilized to break the energy gap law through energy transfer, achieving record-breaking efficiency.

Over millions of years, Earth has experienced cycles of ice ages and warm periods. Today, we find ourselves in a warm period heavily influenced by human activities. As greenhouse gas levels in the atmosphere rise, global warming intensifies, causing ice sheets to melt rapidly, sea levels to rise, and posing severe threats to global ecosystems and human societies. Understanding the mechanisms behind these warming periods by studying past extreme warm periods is a crucial task for modern scientists.

Researchers from the Institute of Industrial Science, The University of Tokyo have found that ice starts forming near the surface of water via structures similar to a rare, recently discovered type of ice, which helps us understand ice formation better

Researchers from the HeKKSaGOn Alliance – involved were scientists from Kyoto University, Osaka University and Heidelberg University (Germany) – synthesized a bio-inspired polymer for water purification. The polymer was designed to mimic phytochelatin, a plant protein that selectively captures and neutralizes harmful heavy metal ions. The hyperconfinement of the polymer enabled a flow-through system and effectively removed cadmium ions from contaminated water, making it safe to drink. The system was selective for heavy metals and provides a new way to remove specific contaminants from water.

This study presents a method to record the temperature of materials with exceptional temporal resolution, using a Doppler broadening effect in neutron resonance absorption. Using a high-powered laser to generate pulses of neutrons 100 nanoseconds long, a test on samples of silver and tantalum successfully returned characteristic information for both materials and their temperatures.

A method to screen a wide variety of drug candidates without laborious purification steps could advance the fight against drug-resistant bacteria.

Researchers from France, Japan, and Italy have developed BiœmuS, a low-cost, flexible, and real-time biomimetic tool designed for biohybrid experiments. This system enables closed-loop interactions between artificial and living neural networks. Moreover, BiœmuS offers accessibility and ease of use, facilitating real-time emulation of neural network dynamics both in vitro and in vivo. This interdisciplinary collaboration aims to enhance bioelectrical therapeutics and neuroprosthetic development.

Researchers from the Institute of Industrial Science, The University of Tokyo, have efficiently removed oxygen from high-oxygen-concentration titanium, which might help reduce the production cost of an otherwise versatile metal.

New genetic tool developed by Duke-NUS could help investigate brain function and psychiatric disorders.

Researchers from Osaka University have found that a specific pattern of brain activity, known as “sharp-wave ripples,” is associated with thoughts that wander from the present situation. This activity begins in the hippocampus, a crucial brain region for memory formation and recall, and is linked to more vivid and less desirable thoughts. A better understanding of the relationship between sharp-wave ripples and these kinds of thoughts might be helpful for treating related conditions.

Researchers from Osaka University developed an in silico library comprising 54 potential triarylborane catalysts for the functionalization of amino acids and peptides with molecular hydrogen as a reductant. This library, together with chemometric machine learning, was used to identify the best candidates. Based on this process, an optimal catalyst was identified and found to promote the alkylation of aniline derivatives with exceptional functional group tolerance and produce only water as a coproduct.

Samples reveal evidence of changes experienced by the surface of asteroid Ryugu, some probably due to micrometeoroid bombardment.

The enzyme PI3K plays a critical role in cell migration. Scientists have long understood this function. But researchers have recently unveiled that a subunit of this enzyme also has the ability to slam on the breaks to this process.

Researchers at Tohoku University and the University of California, Santa Barbara have unveiled a probabilistic computer prototype. Manufacturable with a near-future technology, the prototype combines a complementary metal-oxide semiconductor (CMOS) circuit with a limited number of stochastic nanomagnets, creating a heterogeneous probabilistic computer.

Meandering ocean currents play an important role in the melting of Antarctic ice shelves, threatening a significant rise in sea levels.

Researchers from the Institute of Industrial Science, The University of Tokyo, find that providing lab-grown ‘cerebral organoids’ with connections similar to those in real brains enhances their development and activity

Revelation of the molecular code for constructing brain neural circuits With identification of the characteristics of excitatory synapses and memory cognition regulation mechanisms mediated by synaptic gene microexons - A research team led by DGIST Prof. Jaewon Ko has unearthed the microexon molecular code for the formation of synaptic signal patterns through the synaptic adhesion protein LAR-RPTP. - This finding is expected to provide crucial clues for the development of new brain disease treatments targeting protein complexes.

A team of researchers has proposed a new concept for magnet-based memory devices, which might revolutionize information storage devices owing to their potential for large-scale integration, non-volatility, and high durability.

Innovative technology for the comprehensive analysis of membrane protein extracellular interactions.

Researchers from Nano Life Science Institute (WPI-NanoLSI), Kanazawa University report in Nature Communications that TMEM16F, a transmembrane protein that facilitates the passive movement of phospholipids and ions across membranes, explores a larger conformational landscape than previously thought to perform its unique functions. The finding refines our molecular understanding of crucial physiological processes such as blood coagulation and COVID-19 pathogenesis, and highlights the importance of probing membrane proteins in native-like environments.

Carbon nanostructures could become easier to design and synthesize thanks to a machine learning method that predicts how they grow on metal surfaces. The new approach, developed by researchers at Japan’s Tohoku University and China’s Shanghai Jiao Tong University, will make it easier to exploit the unique chemical versatility of carbon nanotechnology.

- Joint research team of DGIST (Prof. Dae-hyun Nam, Youn-gu Lee) - Sogang Univ. (Prof. Seo-in Back) developed a new catalyst for electrochemical reduction of carbon dioxide using “vitamin C boosting copper nanowire” - Utilizing the jointly developed catalyst accelerates conversion from carbon dioxide to ethylene, enabling mass production of ethylene - Findings published in the prestigious academic journal, “Nature Communications”

Researchers from Osaka University and collaborating partners have improved the efficiency of heat-to-electricity conversion in gallium arsenide semiconductor microstructures. By judicious spatial alignment of electrons within a two-dimensional electron gas system with multiple subbands, one can substantially enhance the power factor compared with previous iterations of analogous systems. This work is an important advance in modern thermoelectric technology and will benefit the global integration of the Internet of Things.

A research team led by Lingnan University's School of Interdisciplinary Studies Assistant Professor Xiao Hang recently devised a “crystal language” that enables artificial intelligence (AI) to create new materials with desired properties (Figure 1). This groundbreaking discovery holds the potential for creating the next revolutionary semiconductor material that makes solar energy abundant and affordable, and opens possibilities for the development of novel superconductors that effortlessly transport clean electricity with zero losses. The findings of this breakthrough research have been published in the prestigious academic journal Nature Communications, which is also the first time Lingnan University scholar published a lead-author paper on the esteemed Nature series.

Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University report in Nature Communications a high-speed atomic force microscopy study of the structural dynamics of sodium ion channels in cell membranes. The findings provide insights into the mechanism behind the generation of cell-membrane action potentials.