Nature Communications

Samples from the asteroid Ryugu collected by the Hayabusa2 mission contain nitrogenous organic compounds, including the nucleobase uracil, which is a part of RNA.

A study led by scientists from Hong Kong Baptist University (HKBU) has identified a protease called MT1-MMP that is a major host factor behind the infectivity of the SARS-CoV-2 virus in the human body, which leads to the infection of COVID-19 and multi-organ failure. By applying a humanised antibody called 3A2 that can inhibit the activity of MT1-MMP, the viral load of infected mice was reduced by almost 90%. The research team also demonstrated that the protease is a potential therapeutic target for COVID-19.

Researchers have revealed the modulatory effect of the anti-inflammatory metabolite itaconate on T helper and T regulatory cells, which may lead to new therapeutic approaches to treating some autoimmune diseases.

Osaka Metropolitan University scientists succeeded in directly observing how LECs—which are attracting attention as one of the post-organic LEDs—change their electronic state over time during field emission by measuring their optical absorption via lamp light irradiation for the first time. This research method can be applied to all light-emitting devices, including not only LECs but also organic LEDs. This method is expected to reveal detailed electroluminescence processes and lead to the early detection of factors that reduce the efficiency of electroluminescence.

Researchers at Tohoku University have analyzed samples from asteroid Ryugu. They identified some of the oldest solids from the solar system to date, and their findings suggest that the asteroid initially formed in the outer reaches of the solar system.

A new approach that ‘baits’ the caps or telomeres protecting the ends of chromosomes could provide information on how rapidly we are ageing and what we need to do to slow it down.

A research group from the Graduate School of Engineering at Osaka Metropolitan University has shown that 3C-SiC exhibits high thermal conductivity equivalent to the theoretical value, based on thermal conductivity evaluation and atomic-level analysis, for the first time. They demonstrated that a 3C-SiC film on silicon substrate had a high thermal conductivity and expect that fabricating large-diameter wafers can be achieved at a low cost. The discovery should lead to improved heat dissipation in everyday electronic devices.

Blocking an immune-regulating protein reverses the damage caused by acute and chronic kidney disease, a preclinical study suggests.

Pyroelectric catalysis (pyro-catalysis) can convert environmental temperature fluctuations into clean chemical energy, like hydrogen. However, compared with the more common catalysis strategy, such as photocatalysis, pyro-catalysis is inefficient due to slow temperature changes in the ambient environment. Recently, a team co-led by researchers at City University of Hong Kong (CityU) triggered a significantly faster and more efficient pyro-catalytic reaction using localized plasmonic heat sources to rapidly and efficiently heat up the pyro-catalytic material and allow it to cool down. The findings open up new avenues for efficient catalysis for biological applications, pollutant treatment and clean energy production.

Metal oxides are a promising catalyst for photoelectrochemical (PEC) water splitting to produce hydrogen as alternative energy. However, their effectiveness is restricted at low voltage. A research team led by scholars from City University of Hong Kong (CityU), Australia and Germany successfully mediated the poor charge carrier transport at low voltage by adding phosphorus to a metal oxide catalyst, which reduced energy losses during water splitting. The findings offer a potential option for achieving carbon neutrality.

New insights into the opposing actions of serotonin-producing nerve fibres in mice could lead to drugs for treating addictions and major depression.

Clean hydrogen energy is a good alternative to fossil fuels and is critical for achieving carbon neutrality. Researchers around the world are looking for ways to enhance the efficiency and lower the cost of hydrogen production, particularly by improving the catalysts involved. Recently, a research team from City University of Hong Kong (CityU) developed a new, ultra-stable hydrogen evolution reaction (HER) electrocatalyst, which is based on two-dimensional mineral gel nanosheets and does not contain any precious metals. The catalyst can be produced in large scale and can help achieve a lower hydrogen price in the future.

Researchers have designed and synthesized analogs of a new antibiotic that is effective against multidrug-resistant bacteria, opening a new front in the fight against these infections.

A research team led by Hong Kong Baptist University (HKBU) has identified a molecular target for bone anabolic therapies using a selected aptamer that serves as an inhibitor of sclerostin, a protein that prevents bone growth. The discovery offers hope for the development of an effective next-generation treatment for osteoporosis and osteogenesis imperfecta that is free of cardiovascular risk compared to the marketed antibody drug.

An international team of researchers has studied the heterostructures of layered antiferromagnets, painting a better picture of what happens when two different magnetic orders are combined.

Silencing the gene, called WWP2, in patients in the early stages of cardiomyopathy could delay progression to heart failure by controlling immune cell infiltration and activation, and halting the formation of excessive scar tissue, preclinical data suggest.

Quinine and various drugs based on its chemical structure have been used to treat malaria for centuries. But parasites resistant to antimalarial drugs are becoming apparent. To pave the way for future medicine development, an efficient way to synthesize quinine was needed. And now a research team from Tohoku University has achieved just that.

First-in-the-world high-resolution imaging allows scientists to study the dengue protein in greater detail to yield valuable insights.

We don’t know much about the Earth’s inner core because recreating its conditions in a laboratory setting remains fraught with difficulties. Based on tracking seismic waves, scientists theorize that the area in and around the core comprises mostly of iron. But the values extracted from these indicators differ from how pure iron typically behaves. Now, a collaborative research group has succeeded, for the first time, in measuring the speed of sound of pure iron under pressures similar to the Earth’s inner core boundary.

Most metal and alloys possess a high elastic strain rate at the micro level. But this changes when they are in their bulk shape, as they are for everyday engineering applications. Now, a research group has developed a bulk copper-based alloy boasting the largest tensile elastic strain at room temperature to date.

Theory-guided development of an easier, more versatile process for synthesizing unsymmetric ligands provides new avenues of exploration in transitional metal catalysis.

Hydrogen, a clean fuel, is incredibly dense in energy—three times more than diesel or gasoline. Its ability to power a sustainable future has been hindered by a lack of high performing catalysts. Now, a collaborative research group has developed nanoporous molybdenum-based intermetallic compounds that could address this conundrum.

Researchers from Osaka University have developed a computational analysis tool called CAPITAL for comparative analysis of single-cell RNA sequencing data with complicated branching trajectories. As cells undergo a dynamic process, they can be placed on a “pseudotime trajectory” to analyze the gene expression changes throughout the process. While previously only straightforward linear trajectories could be compared, CAPITAL is proven to be able to accurately compare branching trajectories, significantly advancing the field of high-throughput single-cell sequencing.

Researchers from Osaka University have found that serum albumin interferes with β2m amyloid fibril formation through macromolecular crowding. Monitoring serum albumin concentrations could therefore help prevent patients from developing dialysis-related amyloidosis, a serious complication of long-term dialysis.

Researchers from Osaka University revealed that the surface electronic structure of topological insulators varies according to its surface atomic structure, even though it was believed to have been protected by the symmetry of the electronic structure inside the crystal and is therefore unaffected by differences in surface atomic structure. This work offers a new means of minimizing the power consumption and increasing the speed of next-generation technology.

- The low-cost, high-energy, long-life lithium-sulfur battery is based on a novel silica/sulfur interlayer. - The battery is expected to be used in next-generation mobile phones, drones, and electric vehicles owing to its high energy density and improved lifespan.

Hokkaido University researchers find a new way of producing the industrially important propylene that is more energy efficient than existing approaches—and in the process turns carbon dioxide into another usable resource. Their pioneering catalyst design thus contributes to the carbon neutralization of the petrochemical industry.

A pathway that malfunctions in advanced non-alcoholic fatty liver disease could be fixed with the aid of spermidine, a compound naturally found in bodily cells and certain whole foods.

The activity of deep-focus earthquakes, which increases with depths from ~400 km to a peak at ~600 km, is enigmatic because conventional brittle failure is unlikely to occur at elevated pressures. Our experiments showed that formation of thin weak layers filled with nano-crystalline olivine/wadsleyite, upon the pressure-induced phase transition of olivine, is the major cause of deep-focus earthquakes on the metastable olivine wedge in deep slabs.

Researchers develop a new integrated framework that factors in the many variables relevant to accurate carbon emissions modeling in the transportation sector, allowing for policymakers to choose the best path to achieve carbon neutrality.