Biology Neuroscience

Researchers from The University of Osaka have found that the rat brain differs from other mammals in the proportion of upper and deep layer neurons in the cortex. This change likely arises from differences in the timing of signaling pathways during early brain development. Importantly, this identified mechanism may have future applications in regenerative medicine for developmental and neurological disorders.

Millions of people across the world suffer from Alzheimer’s disease, where sufferers experience memory impairment. Researchers from Tohoku University and the University of California, Irvine have recently identified dopamine dysfunction as a previously unrecognized mechanism underlying memory impairment. The discovery potentially opens the door to new therapeutic means that could reverse cognitive decline in Alzheimer’s patients across the globe.

Biologists have long puzzled over why organisms with similar numbers of protein-coding genes can differ so dramatically in nervous system complexity. New research points to a potential link between the expanding diversity of RNA-binding proteins, which shape how genetic instructions are processed, and greater brain sophistication.

Assessing the toll of elongated working hours in community-dwelling, middle-aged adults

Scientists at CityUHK achieved a breakthrough in recent months with the discovery a novel compound, named MF-8. The compound and its associated pharmaceuticals demonstrate significant potential to provide safer, more effective treatments for psychiatric and neurological disorders, such as memory impairment, depression and anxiety, while effectively mitigating the side effects associated with existing medications.

The famed Japanese green tea powder may suppress nerve activity associated with sneezing in hay fever, according to a study in mice.

An international collaborative research team, including researchers from the Faculty of Frontier Engineering at Kanazawa University, has for the first time elucidated sex differences in motor unit firing patterns in patients with Parkinson's disease. Utilizing high-density surface electromyography (HD-SEMG), their detailed analysis of motor unit activity revealed that female patients exhibited significantly greater asymmetry in motor unit discharge rates and lower persistent inward currents (PICs) compared to males. These findings suggest that neurodegeneration may be more asymmetrical in females, even when presenting with similar motor symptoms. This study indicates that motor unit behavior can serve as a sensitive evaluation tool to highlight differences in disease presentation between sexes, potentially leading to the development of personalized treatment strategies that consider sex-specific factors in the future.

A potential breakthrough for jet lag and shift work-related sleep disorders. A Japanese research team has discovered a new compound that can advance the body’s internal clock—offering hope for faster recovery from jet lag and better adaptation to night-shift work. The compound, called Mic-628, specifically activates the transcription of a clock gene named Period1 (Per1). When given orally to mice, it advanced their body clocks and activity rhythms, regardless of dosing time. The findings suggest a new approach to controlling circadian rhythms through drug action rather than light exposure.

Symptoms of depression are common among people with asthma, but growing evidence suggests they may arise from biological mechanisms different from those underlying major depressive disorder.

Scientists at the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, have captured real-time images showing how a key brain enzyme organizes itself to help memory formation. Their study, published in Nature Communications, reveals that the enzyme CaMKII forms mixed α/β subunit structures whose interactions stabilize learning-related signals in neurons.

Did you know your brain might be more receptive to learning new things depending on the time of day? This study examined how a 24-hour cycle alters brain plasticity and neuronal excitability in rats.

A research group led by The University of Osaka has discovered that the DNA repair enzyme Polβ plays a crucial role in protecting the developing brain from harmful mutations. The study found that a lack of Polβ leads to a significant increase in small insertions and deletions of DNA, known as indels near CpG sites, which are important regulatory regions in genes. This accumulation of mutations could contribute to neurodevelopmental disorders.

Protein aggregation inhibitor shows lower levels of cell death and paralysis in mice with acute strokes

By just sprinkling it on top and waiting 10 seconds, researchers can use this new fluorescent probe to clearly show synapses, the connection points between brain cells.

New research in model mice suggests low-dose opioids may help improve social interactions in people with autism spectrum disorder.

Researchers at Tohoku University examined the change in brain energy dynamics from induced seizures - which could potentially help us better understand individuals with epilepsy.

At Duke-NUS Medical School scientists are pioneering breakthroughs in precision medicine and regenerative therapies, targeting everything from muscle loss to dramatically extending our years of health.

New research suggesting a link between motor protein Kif23 and microcephaly may be the key to developing more effective treatments for this condition.

Controlling memories in mice means forgetting a light zap, but in humans it could mean letting go of deeply traumatic events.

Fluorescein angiography capable of assessing neural blood flow in chronic nerve compression neuropathy

Researchers at the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, used high-speed atomic force microscopy to observe dynamic changes in AMPA receptors, which are vital for brain communication. Their findings, published in ACS Nano, reveal how these receptors adapt during signal transmission and suggest potential targets for neurological therapies.

Paper-based battery for wearable devices, To pass or not to pass? Kirigami hydrogels rise from cellulose, Climate impact on mountains, Effects of space weathering. Read all in the latest Editor's Choice.

Skilled players show stronger inhibition processes when electing not to pass the ball

Researchers from the Institute of Industrial Science, The University of Tokyo, find that providing lab-grown ‘cerebral organoids’ with connections similar to those in real brains enhances their development and activity

Unleashing stem cells from dog urine, Electronic Tongue, Tapping into human motion energy, How neurons network, and A radical use for plastic bags. Plus Communicating science two decades on. Read all in the latest Editor's Choice.

Researchers from Osaka University and Shenzhen Bay Laboratory found that neuronal activity induces gene expression at sites of acetylation by promoting the emergence of cAMP response element binding protein (CREB), CREB binding protein (CBP), and RNA polymerase II. These proteins are targeted to the appropriate sites by CBP-mediated histone acetylation at activity-dependent gene loci.

DishBrain reveals how human neurons work together to process information. Living model of brain could give insights into the mechanisms of how we understand and experience the world.

Researchers at Kanazawa University report in Nature Communications how calcium ions can block sodium ion channels located in cell membranes. Structural analysis and computer simulations made it possible to identify where and why calcium ions get stuck.

A research team from the Graduate School of Rehabilitation Science at Osaka Metropolitan University investigated the electrophysiological benefits of working in the presence of others from the perspectives of brain and autonomic nervous system activity. The researchers found that parasympathetic activity—which indicates relaxation—was significantly higher when two individuals were working separately than when one individual was working alone. This suggests that arranging the former condition in occupational therapy for individuals with high levels of tension or anxiety in clinical settings may potentially help alleviate these feelings.

Researchers at Kanazawa University report in Science Advances high-speed atomic force microscopy experiments that show the structural and chemical changes in an enzyme thought to play a vital role in modulating the strength of neural connections.