Biology

Researchers at Kanazawa University report in The Journal of Physical Chemistry Letters how to simulate 3D atomic force microscopy images of out-of-equilibrium systems involving biomolecules. The approach makes use of a celebrated equation from thermodynamics applicable to non-equilibrium situations.

A key molecule for cancer metastasis has been identified as a molecule already known for its involvement in cardiovascular disease, suggesting a possible treatment approach for both diseases simultaneously.

A professor emeritus at Tohoku University has unearthed evidence pointing to a strong relationship between the magnitude of mass extinctions and global temperature changes in geologic times. This interesting correlation reveals a more optimistic outlook on future extinction events.

Research team develops functional annotation workflow for genome sequencing of insects

Researchers at the Institute of Industrial Science at The University of Tokyo introduce a machine learning method to help predict past infection from receptor sequences of immune T-cells even when little data is available, which may help improve human health and our understanding of adaptive immunity

A series of drone images taken by researchers from the Wildlife Conservation Society (WCS) and partners may show the world’s most endangered turtle, Swinhoe’s softshell turtle (Rafetus swinhoei).

Saliva and oral cells are important routes for transmission and infection by the novel coronavirus COVID-19. A research group led by Associate Professor Misako Matsubara and Specially Appointed Professor Katsutoshi Yoshizato of Osaka Metropolitan University hypothesized that the body's innate immune system may protect against SARS-CoV-2 infection. The onset and severity of COVID-19 are age-dependent, as are parts of the innate immune system like saliva production and quality, which are significantly reduced in the elderly. They found that saliva from healthy individuals prevented the binding of the SARS-CoV-2 spike protein S1 on the viral envelope to the angiotensin-converting enzyme 2 (ACE2) receptor present on the plasma membrane of human cells in a concentration-dependent manner.

Innate immunity is activated when the pattern recognition receptors (PRRs) recognize pathogen-associated molecular patterns (PAMPs). We show that a liver-derived secretory protein LECT2, a hepatokine, binds to the HGF receptor MET, a proto-oncogene product, to suppress the proliferation signal of MET. LECT2 activates retinoic acid-inducible gene-I, enhancing antiviral and innate immune responses through MET. Thus, LECT2 is an anti-proliferative and immunoregulatory factor that could be a therapeutic target for viral infections and cancer.

A novel molecular pathway involving cell signalling proteins in the brain may explain how stress affects neuropsychiatric lupus with diffuse neuropsychological manifestations.

Important, yet often neglected: Tadpoles play a critical role in the ecology of aquatic habitats. On 279 pages, a new book presents descriptions for 99 species from the southeast Asian island of Borneo, covering all species commonly found, as well as representatives of the more cryptic ones. LIB-scientist Alexander Haas and his team of international collaborators worked over 20 years on its completion and just released “A Guide to the Tadpoles of Borneo”.

Biologists from Hong Kong Baptist University (HKBU) have discovered in Hong Kong waters three new species of hard coral which have never been identified anywhere else in the world. The findings come shortly after their discovery of one new coral and two new nudibranch species, which was announced last year under their research project on coral health in Hong Kong.

Atomic force microscopy (AFM) allows to visualize the dynamics of single biomolecules during their functional activity. All observations are, however, restricted to regions accessible by a fairly big probing tip during scanning. Hence, AFM images only the biomolecular surface with limited spatial resolution, missing important information required for a detailed understanding of the observed phenomena.

The skin’s top layer contains a diverse set of hundreds of lipid molecules called ceramides with varying chain lengths that play a vital role in its barrier function.

Researchers at Kanazawa University report in Biophysics and Physicobiology how to optimize high-speed atomic force microscopy experiments on live cell membranes, so that moving objects like molecules can be properly followed from frame to frame.

A machine rapidly and robustly separates cancer cells from blood samples, overcoming challenges with currently available techniques.

Scientists have revealed the genetic structure and diversity, and inferred the population history, of the wild house mouse across Europe and Asia.

Researchers at Kanazawa University in collaboration with teams from Toyama Prefectural University and BioSeeds Corporation report in ACS Applied Materials & Interfaces the identification of a molecule with enhanced antiproliferative activity in cancer cells. The underlying biomolecular mechanism is the inhibition of an enzyme that is overproduced in several types of cancer.

Potential of a novel therapeutic strategy for rheumatoid arthritis by UHRF1 stabilization We identified an epigenetic regulator UHRF1 that suppresses various pathogeneses in rheumatoid arthritis. The UHRF1 expression level in synovium showed a negative correlation with the severity of pathogenesis in patients with rheumatoid arthritis and mouse arthritis models. In addition, stabilization of the UHRF1 expression achieved improvement of the arthritis pathology. Our results indicate that the stabilization of the UHRF1 protein is a potential therapeutic strategy for rheumatoid arthritis patients.

Scientists have revealed two enzymes that regulate protein degradation of proteins in the cell membrane of plants, and established the roles they play in plant growth and development.

Scientists have described the youngest therizinosaur fossil from Japan and the first in Asia to have been found in marine sediments.

Researchers in Japan demonstrated the benefits of a new non-radioactive, neutral negative staining reagent by imaging viruses at nanometer-scale.

Giants in History: Thai physician and conservationist Boonsong Lekagul (15 December 1907 – 9 February 1992) made major contributions to the preservation of his country’s wildlife by founding organizations including the Association for the Conservation of Wildlife (ACW), writing about Thailand’s natural heritage, and supporting conservation initiatives.

Giants in History: Ground-breaking cancer researcher Kamal Jayasing Ranadive (8 November 1917 – 11 April 2001) advanced the understanding of the causes of leukaemia, breast cancer and oesophageal cancer through the use of animal models.

Giants in History: Little is known about Ali, a teenager from Sarawak, Malaysia, who was chief assistant to the famous naturalist Alfred Wallace.

Hokkaido University researchers have shown how chronic pain leads to maladaptive anxiety in mice, with implications for treatment of chronic pain-related psychiatric disorders in humans.

Researchers set out to find new ways to artificially induce mRNA to respond in ways that could eventually lead to therapeutic outcomes, expanding on the success of the mRNA-based COVID-19 vaccines and opening up new possibilities across a host of possible genetic therapies.

Examination of endangered species’ stem cells unveils ancient genetic links between mammals.

Genome profiling of Staphylococcus argenteus strains unveiled cross-contamination among Japanese retail foods and slaughterhouses.

In a global first, scientists have demonstrated that molecular robots are able to accomplish cargo delivery by employing a strategy of swarming, achieving a transport efficiency five times greater than that of single robots.

Tile patterns in which the same shape is laid out without gaps are found in the compound eyes of insects. Hexagonal tile patterns are common while shrimp eyes have a square pattern. We investigated tile pattern formation using Drosophila and revealed that the compound eye tile pattern is controlled by a geometrical division mechanism, Voronoi tessellation, in addition to physical constraints determined by the combination of the regular distribution and growth of the individual eyes.