Biology

Marine predators have expanded their ranges into the Arctic waters over the last twenty years, driven by climate change and associated increases in productivity.

Asexual, or vegetative, reproduction in plants is controlled by environmental conditions, but the molecular signaling pathways that control this process are poorly understood. Recent research suggests that the KAI2-ligand (KL) hormone is responsible for initiating and terminating the production of gemmae, or genetically identical plantlets, on liverwort plants based on the presence or absence of specific environmental factors.

- The effect of the cycle of G proteins in real time on the two-step structural change of cell membrane receptors has been investigated - This study is expected to be applied to pathologies related to G protein-coupled receptors and on research for their treatments

- DGIST Professor Minseok Kim’s research team has developed an electronic medicine that can restore normal Schwann cell phenotypes in CMT disease models - It presents the potential of electric stimulation-based treatment for chronic peripheral nerve disorders

A research group at Osaka Metropolitan University has succeeded in simply creating an artificial metalloenzyme with the common metal-binding motif 2-his-1-carboxylate, which is found in natural non-heme metalloenzymes. They created a library of 12 different proteins and screened the library and found that the H52A/H58E variant had the best stereoselectivity. It is expected that this research can be expanded to produce a variety of biocatalysts that work under mild conditions.

A group including Osaka Metropolitan University researchers discovered that the rhodopsin—a protein in the eye that detects light—of whale sharks has changed to efficiently detect blue light, which penetrates deep-sea water easily. The amino acid substitutions–one of which is counterintuitively associated with congenital stationary night blindness in humans—aid in detecting the low levels of light in the deep-sea. Although these changes make the whale shark rhodopsin less thermally stable the deep-sea temperature, allows their rhodopsin to keep working. This suggests that the unique adaptation evolved to function in the low-light low-temperature environment where whale sharks live.

Hailey-Hailey disease is a rare, inherited condition characterized by patches of blisters appearing mainly in the skin folds of the arm pits, groin and under the breasts. It is caused by a mutation in the gene that codes for a specific protein. Tohoku University scientists have uncovered some critical details of this protein’s structure, and the findings could build the foundation for developing treatment for Hailey-Hailey disease and other neurodegenerative conditions.

Researchers from Osaka University identified a subset of fibroblastic reticular cells (FRCs) that simultaneously express two proteins, Aldh1a2 and Tie2, making them unique to areas of the omentum called milky spots. Genetic depletion of these cells caused structural disruption of milky spots. The FRCs were critical to the abdominal immune system as they regulated CXCL12 levels, a molecule necessary for lymphocyte recruitment from blood circulation. These insights can help develop novel treatments for intra-abdominal infections.

Parasitic infections in salmonid fish can increase or decrease their vulnerability to angling, depending on their body condition.

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Bioengineers formulated a mathematical model that clarified the importance of bat ear motions in direction detection, making way for lean, mean sonar navigation machines.

Researchers have revealed the modulatory effect of the anti-inflammatory metabolite itaconate on T helper and T regulatory cells, which may lead to new therapeutic approaches to treating some autoimmune diseases.

Researchers at Kanazawa University report in ACS Nano how high-speed atomic force microscopy can be used to study the biomolecular mechanisms underlying gene editing.

Osaka Metropolitan University scientists successfully quantified the total reactive polysulfide content of 22 different types of vegetables, including onions and garlic. They also revealed that reactive polysulfides are not only found in the leek genus (Allium), such as onions and garlic but also in the cruciferous family of vegetables (Brassicaceae), such as broccoli and cabbage.

Researchers from Osaka University identified the role of a protein known as testis-specific kinase substrate (TSKS) in the process of spermiation, the release of mature sperm. Analysis of a gene-modified mouse model in which TSKS is disrupted revealed that TSKS is necessary for sperm to eliminate cytoplasm and become streamlined. These findings may lead to the development of diagnostic tests and male contraceptives.

Scientists have shown that swarming molecular robots can deliver cargo five times more efficiently than a robot working on its own.

Finding extra-terrestrial life would transform how we view our place in the Universe, but reporting on the search for it poses challenges for scientists and the media.

地球外生命が発見されれば、宇宙における私たちの存在意義に変化をもたらすだろう。しかしその探索に関する報道の在り方は、科学者やメディアにとって未だに大きな課題である。

Researchers in Sarawak, Malaysia, measured the immunity responses of people who received different COVID-19 vaccines.

Insights into their diversity will help to understand and protect them and their natural environment.

Two novel hypotheses address the “two-fold cost of sex”: one of the biggest enigmas in the evolution of sexual reproduction.

Osaka Metropolitan University researchers have used 100 seconds of laser irradiation to generate convection currents that selectively accelerate biochemical reactions—due to the photothermal effect—by concentrating biofunctional molecules at the cell surface. Using this method, useful molecules can be transported into cells at concentrations a hundred to a thousand times lower than with conventional methods. Furthermore, they also succeeded in selectively introducing small molecules into intracellular organelles usually impossible at low concentrations (hundreds of pmol/L) as well as inducing cell death in targeted cells by concentrating anticancer active peptides into them at concentrations so low that they would not be conventionally effective (several tens of nmol/L).

Researchers at Kanazawa University report in Nano Letters the discovery of a biomolecular dynamical process likely relevant to gene expression. The process, revealed by means of high-speed atomic force microscopy, involves DNA and its packaging molecules.

Researchers from Osaka University found that Ca2+ signaling simultaneously performed signal amplification and olfactory adaptation. The results demonstrated that this mysterious phenomenon was segregated inside the cilium. A novel system was used to observe changes in Ca2+ dynamics inside the thin structure of a cilium. Unveiling the mystery of Ca2+ signaling segregation further clarifies the mechanisms underlying the human sense of smell.

Changes in our REM sleep patterns could potentially be used to diagnose the severity of epilepsy, a new study by Tohoku University researchers has suggested. They showed that astrocytes - star-shaped glial cells that control the local ionic and metabotropic environment of the brain - exhibit an acid response with REM sleep in mice. They theorize that the acid response could be the underlying drive for specific information processing and generating plasticity during sleep.

Lipid nanoparticles have been used to encapsulate CRISPR-Cas9 and deliver it to cells in mice, where it was highly effective at knocking down expression of a target protein.

Synthetic hydrogels were shown to provide an effective scaffold for neuronal tissue growth in areas of brain damage, providing a possible approach for brain tissue reconstruction.

Sifting through sewage for SARS-CoV-2 genetic material could help authorities tailor infection control policies.

Osaka Metropolitan University scientists found that 2-oxo-imidazole-containing dipeptides (2-oxo-IDPs) exhibit very high antioxidant activity. Furthermore, they established a method to selectively and sensitively detect very small amounts of 2-oxo-IDPs and revealed for the first time that several types of 2-oxo-IDPs are contained in meat, including beef, pork, and chicken.

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