Diseases

An ‘eat-me’ signal displayed on cell surfaces requires activation of a lipid-scrambling protein by a nuclear protein fragment.

Through a series of experiments using nasal polyp organ culture and mouse models of restraint stress, researchers unveil relationship between presence of corticotropin-releasing stress hormone and increase in and degranulation of allergy-causing mast cells.

Study shows that antibody longevity varies widely from 40 days to as long as several decades and not everyone who has recovered from COVID-19 is immune from reinfection. Individuals with low levels of neutralising antibodies may still be protected if they have robust T-cell immunity. Blood tests and a computer algorithm suggest annual vaccinations might be needed for some individuals to prevent future outbreaks of COVID-19.

Scientists have discovered a route of introduction for High Pathogenicity Avian Influenza Virus (HPAIV) H5N8 into Japan and, in parallel, have investigated the potential of two human anti-influenza drugs for the control of HPAI in birds.

This article is an excerpt from the Hokkaido University research magazine “Tackling Global Issues vol.3 Fighting the menace of zoonosis" (link below).

Osaka City University finds that the chemical sesaminol, naturally occurring in sesame seeds, protects against Parkinson’s disease by preventing neuronal damage that decreases the production of dopamine. In vitro experiments show sesaminol handle oxidative stress in cells by regulating the production of reactive oxygen species and the movement of antioxidants. In vivo experiments reveal that a diet of sesaminol increases production of dopamine and significantly improve motor functions in mice.

A Hong Kong Baptist University-led (HKBU) research team has developed a novel drug which has the potential to become a next-generation treatment for cancers associated with Epstein–Barr virus (EBV).

This article is an excerpt from the Hokkaido University research magazine “Tackling Global Issues vol.3 Fighting the menace of zoonosis" (link below).

New study shows that uneven accumulation of amyloid β is linked to olfactory dysfunction or partial loss of smell, an early symptom of Alzheimer’s disease

Springer Nature and the University of Tokyo to hold SDGs Symposium 2021, “Interdisciplinary science solutions for food, water, climate and ecosystems Sustainable Development Goals”

Many genetic variants have been found to have a linkage with genetic diseases, but the understanding of their functional roles in causing diseases are still limited. An international research team, including a biomedical scientist from City University of Hong Kong (CityU), has developed a high-throughput biological assay technique which enabled them to conduct a systematic analysis on the impact of nearly 100,000 genetic variants on the binding of transcription factors to DNA. Their findings provided valuable data for finding key biomarkers of type 2 diabetes for diagnostics and treatments. And they believe that the new technique can be applied to studies of variants associated with other genetic diseases.

A research team from the School of Life Sciences at The Chinese University of Hong Kong (CUHK) has recently discovered that SOX9 protein is an essential regulatory factor of choroid plexus function that ensures the correct composition of cerebrospinal fluid (CSF). The finding, recently published in the prestigious scientific journal Proceedings of the National Academy of Sciences of the United States of America (PNAS), has provided the scientific community a novel understanding to the molecular regulatory mechanisms behind the function of the blood-CSF barrier and lays the groundwork for developing novel therapeutic strategies for preventing and treating neurodevelopmental disorders.

This article is an excerpt from the Hokkaido University research magazine “Tackling Global Issues vol.3 Fighting the menace of zoonosis" (link below).

This article is an excerpt from the Hokkaido University research magazine “Tackling Global Issues vol.3 Fighting the menace of zoonosis" (link below).

In a study published in Gastroenterology – Researchers at Osaka City University and The Institute for Medical Science, The University of Tokyo, in collaboration with Brigham and Women's Hospital in Boston, report the intestinal bacterial and viral metagenome information from the fecal samples of patients with recurrent Clostridioides difficile infection (rCDI). This comprehensive analysis reveals the bacteria and phages involved in pathogenesis in rCDI, and their remarkable pathways important for the recovery of intestinal flora function.

This article is an excerpt from the Hokkaido University research magazine “Tackling Global Issues vol.3 Fighting the menace of zoonosis" (link below).

Researchers from the School of Chinese Medicine (SCM) at Hong Kong Baptist University (HKBU) have developed a Chinese medicine formula named NeuroDefend that offers a potential novel treatment for Alzheimer’s disease (AD). Mouse model experiment results showed that the formula reduces the levels of amyloid-beta (Aβ) and insoluble hyperphosphorylated-tau protein, which are the major hallmarks of AD, in mice brains. It also improves cognitive function and memory in mice.

The COVID-19 outbreak has brought unprecedented challenges to Hong Kong and, according to data from the Chinese Center for Disease Control and Prevention, the highest fatality rate has been in adults aged over 80. In view of this, Lingnan University in Hong Kong (LU) has launched a brand new programme to promote using Chinese medicine to prevent the transmission of COVID-19 in older adults, and reduce the infection risk in the spirit of “prevention is better than cure”.

New ‘armoured’ T cells attack cancer without being suppressed by drugs given to transplant patients to avoid organ rejection.

Investigations of a cellular protein have uncovered a possible link with schizophrenia.

iCeMS scientists have revealed how a transporter protein twists and squeezes compounds out of cells, including chemotherapy drugs from some cancer cells.

Researchers baffled by an infant’s rare encephalitis case unusual in children found unheard-of mutations and a new way to examine the “immunity gene.”

A research team, affiliated with South Korea's Ulsan National Institute of Science and Technology (UNIST) has been selected as the recipient of a large-scale Social Science Korea (SSK) project of the National Research Foundation of Korea.

Cancer is a disease driven by mutations that alter the way biochemical signals control cell growth, division and migration. Scientists at Duke-NUS Medical School found out that, like Goldilocks, cancer is very picky about getting rapid growth just right.

A research team, affiliated with South Korea's Ulsan National Institute of Science and Technology (UNIST) has succeeded in generating bipotential self-renewing iVPCs by direct lineage conversion.

A research team, affiliated with South Korea's Ulsan National Institute of Science and Technology (UNIST) established an advanced direct conversion strategy to generate iMNs from human fibroblasts in large-scale with high purity, thereby providing a cell source for treatment of SCI.

A Singapore study finds patients with chronic kidney disease need tailored nutrition guidance, as well as better communication with doctors and family support, to empower them to manage their condition.

U.S. Food and Drug Administration (FDA) issued an emergency use authorization (EUA) for cPass™ SARS-CoV-2 Neutralization Antibody Detection Kit on 6th November 2020.

MANILA, PHILIPPINES (10 November 2020) — The Asian Development Bank (ADB) has partnered with leading healthcare knowledge provider, the BMJ, to launch a new online coronavirus disease (COVID-19) Information Centre for healthcare professionals tackling the pandemic.

Professor Hyug Moo Kwon, affiliated with South Korea's Ulsan National Institute of Science and Technology (UNIST) has published a review paper at 'Nature Review Nephrology'.