Health

COVID-19 has had a massive impact on both our physical health and psychological health. Using data from the 2011 Great East Japan Earthquake and Tsunami, researchers at Tohoku University have sought to find ways to mitigate the mental health impacts of COVID-19 on adolescents.

Researchers reveal through a systematic review of 158 articles detailing quality improvements in pediatric intensive care units mainly throughout North America and the U.K. that despite having a median score of 11.0 on the Quality Improvement Minimum Quality Criteria Set, only 17% of them were considered high quality by achieving a 14-16 score, and only 5% cited Standards for QUality Improvement Reporting Excellence (SQUIRE) guidelines for reporting quality improvement works.

A hydrogel, a type of soft matter, developed at Hokkaido University successfully reverted cancer cells back to cancer stem cells within 24 hours, in six different human cancer types. This could lead to the development of anti-cancer stem cell drugs and personalized medicines.

Multi-country trial finds low-cost intervention to improve hypertension management in rural communities is cost-effective. Consisting of home visits by community healthcare workers, physician training and coordination with public health care infrastructure, the intervention can be scaled up in low- and middle-income countries.

Researchers from the University of Tsukuba find that vigorous exercise causes imperceptible improvements in sleep quality Tsukuba, Japan—Physical exercise has long been prescribed as a way to improve the quality of sleep. But now, researchers from Japan have found that even when exercise causes objectively measured changes in sleep quality, these changes may not be subjectively perceptible. In a study published this month in Scientific Reports, researchers from the University of Tsukuba have revealed that vigorous exercise was able to modulate various sleep parameters associated with improved sleep, without affecting subjective reports regarding sleep quality.

An ‘eat-me’ signal displayed on cell surfaces requires activation of a lipid-scrambling protein by a nuclear protein fragment.

Professor David Matchar and his team from the Health Services and Systems Research (HSSR) Programme at Duke-NUS bagged two prestigious awards at the International Stroke Conference 2021, held virtually on 17-19 March, 2021.

Through a series of experiments using nasal polyp organ culture and mouse models of restraint stress, researchers unveil relationship between presence of corticotropin-releasing stress hormone and increase in and degranulation of allergy-causing mast cells.

Study shows that antibody longevity varies widely from 40 days to as long as several decades and not everyone who has recovered from COVID-19 is immune from reinfection. Individuals with low levels of neutralising antibodies may still be protected if they have robust T-cell immunity. Blood tests and a computer algorithm suggest annual vaccinations might be needed for some individuals to prevent future outbreaks of COVID-19.

Scientists at Tohoku University looked into the impacts of the COVID-19 pandemic on the mental health of pregnant women in Japan.

Scientists have discovered a route of introduction for High Pathogenicity Avian Influenza Virus (HPAIV) H5N8 into Japan and, in parallel, have investigated the potential of two human anti-influenza drugs for the control of HPAI in birds.

Collecting liver tissue from 22 postoperative patients with long-term post-Fontan surgery, researchers have found a specific liver fibrosis to develop from the sinusoidal region which is difficult to accurately assess by conventional examination methods (ultrasound elastography and blood tests).

In honour of International Women's Day, we are highlighting women in research. More than 50 experts across a wide range of disciplines are prepared to speak with international media about their research and women in STEM.

This article is an excerpt from the Hokkaido University research magazine “Tackling Global Issues vol.3 Fighting the menace of zoonosis" (link below).

Osaka City University finds that the chemical sesaminol, naturally occurring in sesame seeds, protects against Parkinson’s disease by preventing neuronal damage that decreases the production of dopamine. In vitro experiments show sesaminol handle oxidative stress in cells by regulating the production of reactive oxygen species and the movement of antioxidants. In vivo experiments reveal that a diet of sesaminol increases production of dopamine and significantly improve motor functions in mice.

A Hong Kong Baptist University-led (HKBU) research team has developed a novel drug which has the potential to become a next-generation treatment for cancers associated with Epstein–Barr virus (EBV).

Vitamin B6 may help calm cytokine storms and unclog blood clots linked to COVID-19's lethality. But research on it is lacking. A Hiroshima University researcher calls on fellow scientists to study its potential role.

This article is an excerpt from the Hokkaido University research magazine “Tackling Global Issues vol.3 Fighting the menace of zoonosis" (link below).

Medical staff and researchers from Tohoku University and Fukushima Medical University conducted a collaborative, multifaceted training program for healthcare workers to better prepare them for disasters. The training incorporated a wide range of subjects such as data analysis, cultural revitalization in the wake of disasters, and post-disaster psychological and physical well-being.

A research team implemented a study based on a program that encouraged elderly patients at care homes in Adachi Ward, Tokyo to participate in activities such as park cleaning, gardening, and shopping. Their results revealed a surprising behavioral change.

Polyacrylamide gel electrophoresis enables high-resolution separation of proteins extracted from biological samples, but it requires more than one day of pretreatment to recover the separated proteins trapped inside the gel for detection by mass spectrometry. BAC-DROP, our novel electrophoresis technology, uses a dissolvable form of polyacrylamide gel, which allows sample pretreatment to be completed in about 5 hours. The developed technology will enable the rapid diagnosis of viruses and disease protein markers.

This article is an excerpt from the Hokkaido University research magazine “Tackling Global Issues vol.3 Fighting the menace of zoonosis" (link below).

This article is an excerpt from the Hokkaido University research magazine “Tackling Global Issues vol.3 Fighting the menace of zoonosis" (link below).

ARN's February newsletter features research about catalyzing plastic recycling, the mental health toll of the COVID-19 pandemic, antiperovskites and oolong tea. In honor of International Day of Women and Girls in Science, we also have tips for addressing gender bias in STEM communications, and inspirational stories about pioneering female scientists from our Giants in History series. Read on...

A brain enzyme activates dormant neural stem cells, revealing how defects in its gene could lead to neurodevelopmental disorders.

A research group has created a device that measures how our bodies metabolize fat via our breath, allowing for the development of efficient fat burning exercises.

In a study published in Gastroenterology – Researchers at Osaka City University and The Institute for Medical Science, The University of Tokyo, in collaboration with Brigham and Women's Hospital in Boston, report the intestinal bacterial and viral metagenome information from the fecal samples of patients with recurrent Clostridioides difficile infection (rCDI). This comprehensive analysis reveals the bacteria and phages involved in pathogenesis in rCDI, and their remarkable pathways important for the recovery of intestinal flora function.

Although genome sequencing has come leaps and bounds over the past 20 years, there did not exist a reference genome specific to the Japanese. That is until now. Researchers at Tohoku University have completed and released the first Japanese reference genome by analyzing the genomes of three Japanese individuals using high coverage, long-read next-generation sequencing technologies.

COVID-19 has led to psychological distress among one in three adults, large-scale meta-analysis by researchers at Duke-NUS Medical School, Singapore, reveals.

A new technique allowed researchers to observe in greater detail how heat alters keratin proteins, helping in their search for ingredients that can prevent heat-damaged hair.