Peer Reviewed

Researchers from Osaka University found that patients with persistently high levels of urinary albumin excretion in the long term are at high risk of new-onset heart failure. Preventive treatment associated with the lowering of urinary albumin excretion levels in these patients could reduce the risk of later heart failure or mortality.

Researchers from Osaka University have demonstrated a proof-of-concept for identifying single nucleotides by using quantum computing. Molecular rotation patterns—and the corresponding variations in conductance—within the nanoscale gap between two electrodes enabled the development of a quantum gate for the nucleotide adenosine monophosphate. Developing quantum gates for the other three nucleotides, and incorporating this technology into DNA sequencing workflows, could revolutionize genome analysis.

Enantioselection with neither chiral catalysis nor chiral ingredients (absolute enantioselection) has been one of the most active topics of interest but its experimental realizations have been challenging. A team led by researchers at the Institute for Molecular Science (IMS) demonstrated the enantioselectivity of helical supramolecules consisting only of achiral molecules solely by exploiting chiral-induced spin selectivity (CISS) effect. The helicity of the supramolecules is created not by microscopic molecular arrangements but by mesoscopically introduced dislocations. Now CISS effect has been revealed to be relevant for the wider class of chirality ranging from microscopic to mesoscopic length scales.

Scientists have isolated potent neutralising antibodies from a COVID-19 vaccinated SARS survivor that exhibited remarkable breadth against known sarbecoviruses. The antibodies targeted a conserved region of the spike protein and blocked receptor binding and viral fusion. These findings could guide the development of broadly active therapeutics against current and future coronaviruses.

High-entropy alloys (HEA) have a unique chemical composition that makes them strong, ductile, and resistant to wear-and-tear even at high temperatures. Yet this chemical composition also makes them difficult to study. Now, a collaborative research team has created a new experimental platform that enables the control of the atomic-level structure of HEAs’ surfaces and the ability to test their catalytic properties.

succeeded in preparing atactic C1 polymers with a high melting point of up to 130 ℃ by utilizing a hydrogen-bonding interaction among amide-linkages incorporated into the polymer side-chains.

Elucidation of global anti-aromaticity (aromaticity) in homoHPHAC+ (homoHPHAC3+) with electron-accepting to electron-donating substituents

Researchers from Osaka University use quasi-elastic neutron scattering to get a close look at the behavior of water molecules in a semiclathrate hydrate crystal. They found that the molecules showed fast reorientation with an activation energy similar to that of cleaving a hydrogen bound. This rapid relaxation time in the solid electrolyte is expected to lead to efficient, cost-effective, and safe applications for semiclathrate hydrates in batteries and thermal storage materials.

Researchers at Tohoku University have unraveled the reasons behind the underperformance of a promising field of catalysis known as dual atom catalysts (DACs). Their findings shed light on the challenges faced by DACs in converting carbon dioxide into valuable multicarbon products.

Lactate is a byproduct of exercise and metabolism, fueling our brain when oxygen is limited. More recently, scientists have become aware of the many roles it plays in developing our nervous system. Now, researchers from Tohoku University have unearthed the cellular mechanisms by which lactate helps our brains develop.

An exquisitely preserved fossil forest from Japan provides missing links and helps reconstruct a whole Eurasia plant from the late Miocene epoch.

Researchers from the Institute of Industrial Science, The University of Tokyo, provide physical insights into porous soft materials, which will facilitate the design of many energy, medical, and other technologies.

Current evidence suggests that microparticles of cosmic dust collide and stick together to form larger dust aggregates that may eventually combine and develop into planets. Numerical models that accurately characterize the conditions required for colliding microparticle aggregates to stick together, rather than bounce apart, are therefore paramount to understanding the evolution of planets. Recent modeling suggests that dust aggregates are less likely to stick together after a collision as the size of the aggregates increases.

Researchers from Northwestern University and recently joining the Institute for Industrial Science, The University of Tokyo develop a high-throughput approach to evaluate protein folding stability in thousands of proteins .

Japan’s population may be on the decline, but it is the opposite for many wildlife species. This has increased the number of human-wildlife interactions. Controversially, lethal management is sometimes employed to manage this issue. But a holistic understanding of the public’s attitude to this approach has been lacking. Now, researchers have surveyed the public’s opinion on the topic, hoping to provide data that can direct future management practices.

A joint research group at Osaka Metropolitan University conducted a survey on prevalence of obesity and factors associated with low obesity among 423 adolescents between the ages of 14 and 19 living in Harare, Zimbabwe. The results revealed that 15.8% were obese or overweight. The study also revealed that 27.1% of the participants had low obesity awareness, which was significantly related to parents/guardians' lack of formal education and insufficient knowledge about eating habits.

Scientists have combined two light wavelengths to deactivate a bacterium that is invulnerable to some of the world’s most widely used antibiotics, giving hope that the regime could be adapted as a potential disinfectant treatment.

Omega-3 lysolipids are important for protecting the liver from dietary fat, according to Duke-NUS researchers and collaborators from SGH.

Researchers from Osaka University have developed a fluorescent sensor that may be useful for understanding how cells recognize themselves versus other cells when making connections in the brain. Specifically, their sensor can be used to visualize not only connections between cells, but also the disassociation of these interactions. Because neuronal self-connectivity has been implicated in brain disorders like epilepsy and autism, a better understanding of this process may result in improved therapies.

The physiological mechanisms underlying severe burns are not well understood. Researchers at Osaka University used mass spectrometry to identify key blood proteins associated with burn mortality. Ultimately, three proteins (HBA1, TTR, SERPINF2) were very highly correlated with morality rates. Further research into these proteins and their pathways may lead to better drugs to treat people with life-threatening burns.

RNases have been proposed as a treatment against systemic autoimmune diseases. Researchers from Osaka University showed that RNases have a dual action. In some cases, RNases are detrimental and stimulate the immune response by promoting the binding of antibodies to their targets. These findings will improve the understanding and treatment of systemic autoimmune disorders.

A research team has discovered an astounding array of unexplored protein folds. This research will expand our understanding of the depth of the protein universe and the possibilities for de novo design of functional proteins.

The entire biosynthetic pathway of actinopyridazone has been unveiled, revealing that an unprecedented carrier protein-mediated ring-forming step is key to its synthesis.

Researchers at Kanazawa University report in Science Advances high-speed atomic force microscopy experiments that show the structural and chemical changes in an enzyme thought to play a vital role in modulating the strength of neural connections.

Osaka Metropolitan University scientists have successfully developed a model that utilizes AI to accurately classify cardiac functions and valvular heart diseases from chest radiographs. The Area Under the Curve, or AUC, of the AI classification showed a high level of accuracy, exceeding 0.85 for almost all indicators and reaching 0.92 for detecting left ventricular ejection fraction—an important measure for monitoring cardiac function.

The composition of the Earth’s earliest atmosphere

How have the atmosphere and mantle oxidation state of the Earth changed?

A new method for connecting neurons in neuromorphic wetware has been developed by researchers from Osaka University and Hokkaido University. The wetware comprises conductive polymer wires grown in a three-dimensional configuration, done by applying square-wave voltage to electrodes submerged in a precursor solution. The voltage can modify wire conductance, allowing the network to be trained. This fabricated network is able to perform unsupervised Hebbian learning and spike-based learning.

- DGIST-Chungnam National University Team Creates Real-Time Digital Twin Multiphysics Model for Predicting Electrochemical and Mechanical Properties of Micro-Particles for the First Time - Cover Paper Recognition: Chosen by Prominent Journal Advanced Energy Materials

- A research team led by Dr. Byeong-dae Choi at the Division of Electronics & Information System, DGIST, greatly improved the efficiency of electroluminescent devices by applying silver nanofilms. - This opens up the possibility of developing affordable digital film signage.